当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells.

Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells.

Abstract：

:We examined the effects of troglitazone on expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Troglitazone dose-dependently increased expression of E-cadherin and claudin 4 mRNA and protein in PK-1 cells. Snail, Slug and ZEB1, mRNAs were not changed by troglitazone, indicating that these three transcriptional repressors would not play a role in the induction of E-cadherin by troglitazone. GW9662, a PPARgamma antagonist, failed to block the increased expression of E-cadherin or claudin 4 mRNA, suggesting a PPARgamma-independent pathway. A MEK inhibitor, U0126, increased E-cadherin or claudin 4 mRNA and protein expression, and potently inhibited cell invasion. Because troglitazone down-regulates MEK-ERK signaling and inhibit cell invasion in PK-1 as shown in our previous study, these results suggest that troglitazone increases expression of E-cadherin and claudin 4 possibly through inhibition of MEK-ERK signaling in pancreatic cancer cells, which might be involved in the troglitazone-induced inhibition of cell invasive activity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kumei S,Motomura W,Yoshizaki T,Takakusaki K,Okumura T

doi

10.1016/j.bbrc.2009.01.134

subject

Has Abstract

pub_date

2009-03-13 00:00:00

pages

614-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)00190-9

journal_volume

380

pub_type

杂志文章

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