当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Protease-activated receptor 2 exacerbates adenine-induced renal tubulointerstitial injury in mice.

Protease-activated receptor 2 exacerbates adenine-induced renal tubulointerstitial injury in mice.

Abstract：

:Hypercoagulability is associated with chronic kidney disease (CKD). Tissue factor/factor VIIa complex and factor Xa in the coagulation cascade are known to activate protease-activated receptor 2 (PAR2), and to cause inflammation and tissue injury. Although PAR2 is highly expressed in the kidney, it is unclear whether PAR2 plays a pathogenic role in CKD. To test this, we fed the mice lacking Par2 (F2rl1-/-) and wild type (F2rl1+/+) mice with adenine diet to induce tubulointerstitial injury, a hallmark of CKD. Adenine-treated mice showed severe renal dysfunction, tubular atrophy, and fibrosis. Fibrin deposition and the expression of tissue factor and PARs markedly increased in their kidneys. Lack of Par2 attenuated renal histological damage and reduced the expression levels of genes related to inflammation, fibrosis, and oxidative stress. Our data indicate that PAR2 is critically important in the pathogenesis of adenine-induced tubular injury. PAR2 antagonists under development could be useful to treat and prevent CKD.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hayashi S,Oe Y,Fushima T,Sato E,Sato H,Ito S,Takahashi N

doi

10.1016/j.bbrc.2016.12.108

subject

Has Abstract

pub_date

2017-01-29 00:00:00

pages

547-552

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(16)32168-4

journal_volume

483

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Glucose and galactose regulate intestinal absorption of cholesterol.

    abstract：:A dose-dependent increase in cholesterol absorption was induced by glucose addition (0-75 mM) to the apical medium of TC7 cells, a well-characterized clone of Caco-2. The uptake into the cells and the secretion rate to the basolateral space were both enhanced by glucose and galactose. This up-regulation was suppressed...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.08.150

    authors： Play B,Salvini S,Haikal Z,Charbonnier M,Harbis A,Roussel M,Lairon D,Jourdheuil-Rahmani D

    更新日期：2003-10-17 00:00:00

  • Pramipexole pretreatment attenuates myocardial ischemia/reperfusion injury through upregulation of autophagy.

    abstract：:This article investigated the effects of pramipexole on myocardial ischemia reperfusion (I/R) injury and its underlying mechanisms. We utilized an in vivo mouse model of myocardial I/R injury and an in vitro H9c2 cell model of hypoxia/reoxygenation (H/R) injury. Pramipexole pretreatment in male C57BL/6 mice significan...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.04.026

    authors： Mo Y,Tang L,Ma Y,Wu S

    更新日期：2016-05-13 00:00:00

  • Glucose and insulin are needed for optimal defensin expression in human cell lines.

    abstract：:Many infections are associated with diabetes, as the ability of the body to fight pathogens is impaired. Recently, low levels of defensins have been found in diabetic rodents. However, whether hyperglycemia and/or insulin deficiency/insensitivity is the reason for the reduced defensin levels is still unknown. To study...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.12.158

    authors： Barnea M,Madar Z,Froy O

    更新日期：2008-03-07 00:00:00

  • RANKL blockade suppresses pathological angiogenesis and vascular leakage in ischemic retinopathy.

    abstract：:Receptor activator of NF-κB ligand (RANKL) is a member of the TNF superfamily. RANKL increases endothelial permeability and induces angiogenesis, suggesting its critical roles in the vasculature. Despite the evidence implicating RANKL in vascular pathology, its role in ischemic retinopathy has not been previously repo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.06.046

    authors： Ock S,Park S,Lee J,Kim J

    更新日期：2019-08-20 00:00:00

  • Angiotensin II modulates ion transport in rat proximal tubules through CYP metabolites.

    abstract：:To assess the effect of angiotensin II on ion transport in rat isolated proximal tubules and establish the arachidonic acid cytochrome P450 metabolites' role mediating angiotensin II effect and to analyze whether corticosteroids play a role modulating this effect, we studied the effect of low (10 and 100 pM) and high ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2807

    authors： Sánchez-Mendoza A,López-Sánchez P,Vázquez-Cruz B,Rios A,Martínez-Ayala S,Escalante B

    更新日期：2000-06-07 00:00:00

  • Biological properties of purified recombinant HCV particles with an epitope-tagged envelope.

    abstract：:To establish a simple system for purification of recombinant infectious hepatitis C virus (HCV) particles, we designed a chimeric J6/JFH-1 virus with a FLAG (FL)-epitope-tagged sequence at the N-terminal region of the E2 hypervariable region-1 (HVR1) gene (J6/JFH-1/1FL). We found that introduction of an adaptive mutat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.04.081

    authors： Takahashi H,Akazawa D,Kato T,Date T,Shirakura M,Nakamura N,Mochizuki H,Tanaka-Kaneko K,Sata T,Tanaka Y,Mizokami M,Suzuki T,Wakita T

    更新日期：2010-05-14 00:00:00

  • Glycyl-tRNA synthetase from Nanoarchaeum equitans: The first crystal structure of archaeal GlyRS and analysis of its tRNA glycylation.

    abstract：:This study reports the X-ray crystallographic structure of the glycyl-tRNA synthetase (GlyRS) of Nanoarchaeum equitans - a hyperthermophilic archaeal species. This is the first archaeal GlyRS crystal structure elucidated. The GlyRS comprises an N-terminal catalytic domain and a C-terminal anticodon-binding domain with...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.01.142

    authors： Fujisawa A,Toki R,Miyake H,Shoji T,Doi H,Hayashi H,Hanabusa R,Mutsuro-Aoki H,Umehara T,Ando T,Noguchi H,Voet A,Park SY,Tamura K

    更新日期：2019-04-02 00:00:00

  • DNA triple helix stabilization by bisguanidinyl analogues of biogenic polyamines.

    abstract：:The polycationic nature of biogenic polyamines such as spermine (SPM, 1) and spermidine (SPD, 2) plays an important role in selective binding to polyanionic nucleic acids. These interactions are mediated by electrostatic and hydrogen bonding forces which led to stabilization of DNA duplexes and triplexes. Transformati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0759

    authors： Pallan PS,Ganesh KN

    更新日期：1996-05-15 00:00:00

  • Effects of C-reactive protein on atherogenic mediators and adrenomedullin in human coronary artery endothelial and smooth muscle cells.

    abstract：:We examined the effects of recombinant human C-reactive protein (rhCRP) on atherosclerosis-related factors in cultured human coronary artery endothelial and smooth muscle cells (HCAECs and HCASMCs). After removing endotoxin from commercial rhCRP preparations using the appropriate column, the purified (P)-rhCRP retaine...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.01.004

    authors： Nagoshi Y,Kuwasako K,Cao YN,Kitamura K,Eto T

    更新日期：2004-02-20 00:00:00

  • Gain-of-function mutation of FGFR3 results in impaired fracture healing due to inhibition of chondrocyte differentiation.

    abstract：:Fracture healing is a complicated regeneration process which to some extent recapitulates bone development. Fibroblast growth factor receptor 3 (FGFR3) has a negative regulatory effect on endochondral ossification, and FGFR3 is also expressed in prehypertrophic and hypertrophic chondrocytes during fracture healing. Ho...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.08.165

    authors： Su N,Yang J,Xie Y,Du X,Lu X,Yin Z,Yin L,Qi H,Zhao L,Feng J,Chen L

    更新日期：2008-11-21 00:00:00

  • Calcium ion-regulated phospholipase C activity in bovine rod outer segments.

    abstract：:Bovine retinal rod outer segment membranes are enriched in a phosphoinositide-specific phosphodiesterase (phospholipase C) activity strictly modulated by free calcium ion concentration. The enzyme(s) was highly active on phosphatidylinositol 4,5-bisphosphate: maximal hydrolysis rate was attained at 10(-5)M Ca2+ and ac...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81054-x

    authors： Panfoli I,Morelli A,Pepe I

    更新日期：1990-11-30 00:00:00

  • MtHsp70-CLIC1-pulsed dendritic cells enhance the immune response against ovarian cancer.

    abstract：:Approximately 80% of ovarian cancer (OC) is diagnosed at late stages, and most patients die within 5 years of diagnosis due to recurrence or drug resistance. Novel treatments are required to improve patient survival. Immune therapy against cancer is promising; however, therapeutic vaccination has been limited by the i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.10.094

    authors： Yu W,Qu H,Cao G,Liu C,Deng H,Zhang Z

    更新日期：2017-12-09 00:00:00

  • Regulation of the localization and stability of Cdc6 in living yeast cells.

    abstract：:The Cdc6 protein is an essential regulator for initiation of DNA replication. Following the G1/S transition, Cdc6 is degraded through a ubiquitin-mediated proteolysis pathway. In this study, we tagged Cdc6 with green fluorescent protein (GFP) and used site-specific mutations to study the regulation of Cdc6 localizatio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01082-9

    authors： Luo KQ,Elsasser S,Chang DC,Campbell JL

    更新日期：2003-07-11 00:00:00

  • Bidirectional regulation of mitochondrial gene expression during developmental neuroplasticity of visual cortex.

    abstract：:The first several months of life are a critical period for neuronal plasticity in the visual cortex, during which anatomical and physiological development depends upon visual experience. Rearing in darkness slows the time course of this critical period, such that at 5 weeks normal cats are more plastic than dark-reare...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5706

    authors： Yang C,Silver B,Ellis SR,Mower GD

    更新日期：2001-10-12 00:00:00

  • Inflammatory mediator bradykinin increases population of sensory neurons expressing functional T-type Ca(2+) channels.

    abstract：:T-type Ca(2+) channels are important regulators of peripheral sensory neuron excitability. Accordingly, T-type Ca(2+) currents are often increased in various pathological pain conditions, such as inflammation or nerve injury. Here we investigated effects of inflammation on functional expression of T-type Ca(2+) channe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.02.118

    authors： Huang D,Liang C,Zhang F,Men H,Du X,Gamper N,Zhang H

    更新日期：2016-04-29 00:00:00

  • A salt bridge between an N-terminal coiled coil of gp41 and an antiviral agent targeted to the gp41 core is important for anti-HIV-1 activity.

    abstract：:HIV-1 envelope glycoprotein transmembrane subunit gp41 play a critical role in the fusion of viral and target cell membranes. The gp41 C-terminal heptad repeat region interacts with the N-terminal coiled-coil region to form a six-stranded core structure. Peptides derived from gp41 C-terminal heptad repeat region (C-pe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2411

    authors： Jiang S,Debnath AK

    更新日期：2000-04-02 00:00:00

  • Induction of endogenous glutathione by the chemoprotective agent, 3H-1,2-dithiole-3-thione, in human neuroblastoma SH-SY5Y cells affords protection against peroxynitrite-induced cytotoxicity.

    abstract：:Substantial evidence suggests that peroxynitrite generated from the bi-radical reaction of nitric oxide and superoxide is critically involved in the pathogenesis of neurodegenerative disorders, such as Parkinson's disease. Reaction with sulfhydryl (SH)-containing molecules has been proposed to be a major detoxificatio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.02.156

    authors： Cao Z,Hallur S,Qiu HZ,Peng X,Li Y

    更新日期：2004-04-16 00:00:00

  • Compensatory expression of p73 in PARP-deficient mouse fibroblasts as response to a reduced level of regularly spliced wild-type p53 protein.

    abstract：:We have investigated the effect of PARP gene inactivation on the expression of wild-type (wt) p53 protein. Using immortalized fibroblasts from control and PARP knock-out mice we have found by immunoblotting with the PAb421 antibody a profound decrease of the p53 expression to a barely detectable level in PARP knock-ou...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0191

    authors： Schmid G,Wang ZQ,Wesierska-Gadek J

    更新日期：1999-02-16 00:00:00

  • Up-regulation of ganglioside biosynthesis, functional synapse formation, and memory retention by a synthetic ceramide analog (L-PDMP).

    abstract：:To address the role of brain gangliosides in synaptic activity, the ceramide analogs, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) and its enantiomer, L-PDMP, were used to inhibit and stimulate ganglioside biosynthesis in cultured cortical neurons. Prolonged treatment with both PDMP isomers exhibi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7194

    authors： Inokuchi J,Mizutani A,Jimbo M,Usuki S,Yamagishi K,Mochizuki H,Muramoto K,Kobayashi K,Kuroda Y,Iwasaki K,Ohgami Y,Fujiwara M

    更新日期：1997-08-28 00:00:00

  • C-terminal tail of NADPH oxidase organizer 1 (Noxo1) mediates interaction with NADPH oxidase activator (Noxa1) in the NOX1 complex.

    abstract：:NOX1 (NADPH oxidase) similar to phagocyte NADPH oxidase, is expressed mainly in the colon epithelium and it is responsible for host defense against microbial infections by generating ROS (reactive oxygen species). NOX1 is activated by two regulatory cytosolic proteins that form a hetero-dimer, Noxo1 (NOX organizer 1) ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.06.083

    authors： Shrestha P,Yun JH,Ko YJ,Kim M,Bae YS,Lee W

    更新日期：2017-08-26 00:00:00

  • WITHDRAWN: ALDH1A1 induces resistance to CHOP in diffuse large B-cell lymphoma through activation of the JAK2/STAT3 pathway.

    abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 撤回出版物

    doi：10.1016/j.bbrc.2016.12.015

    authors： Jiang J,Liu Y,Tang Y,Li L,Zeng R,Zeng S,Zhong M

    更新日期：2016-12-03 00:00:00

  • Tumor necrosis factor-alpha increased the integrin alpha 2 beta 1 expression and cell attachment to type I collagen in human dermal fibroblasts.

    abstract：:Cell adhesion molecules of human dermal fibroblasts play an important role in the processes of wound healing. The effects of tumor necrosis factor- alpha (TNF) on the expression of integrin beta 1 subfamily in human dermal fibroblasts were examined. TNF preferentially induced the expression of alpha 2 beta 1 integrins...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1411

    authors： Ezoe K,Horikoshi T

    更新日期：1993-04-15 00:00:00

  • Unique CCT repeats mediate transcription of the TWIST1 gene in mesenchymal cell lines.

    abstract：:TWIST1, a basic helix-loop-helix transcription factor, plays critical roles in embryo development, cancer metastasis and mesenchymal progenitor differentiation. Little is known about transcriptional regulation of TWIST1 expression. Here we identified DNA sequences responsible for TWIST1 expression in mesenchymal linea...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.11.114

    authors： Ohkuma M,Funato N,Higashihori N,Murakami M,Ohyama K,Nakamura M

    更新日期：2007-01-26 00:00:00

  • EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2.

    abstract：:Cancer metastasis involves tumor cells invading the surrounding tissue. Remodeling of tissue barriers depends on the ability of tumor cells to degrade the surrounding collagen matrix and then migrate through the matrix defects. Epidermal growth factor (EGF) has been shown to regulate tumor cell invasion through activa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.12.080

    authors： Binker MG,Binker-Cosen AA,Richards D,Oliver B,Cosen-Binker LI

    更新日期：2009-02-06 00:00:00

  • Xenopus Suppressor of Hairless 2 is involved in the cell fate decision during gastrulation through the transcriptional regulation of Xoct25/91.

    abstract：:We have previously indicated that Xenopus Suppressor of Hairless 2, XSu(H)2, is involved in the morphogenesis of gastrula embryos in a different manner from the XESR-1-mediated Notch signaling pathway. To address the downstream factors of XSu(H)2, we investigated the effect of XSu(H)2 on XenopusPOU-V genes, Xoct25 and...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.087

    authors： Ito M,Nishitani E,Kinoshita T

    更新日期：2007-02-16 00:00:00

  • A larval specific lipoprotein: purification and characterization of a blue chromoprotein from Heliothis zea.

    abstract：:The green color of the hemolymph of last instar larvae of the corn earworm, Heliothis zea (Boddie), is caused by the appearance of a blue chromoprotein. This protein (Mr approximately 560,000) is composed of 4 subunits (Mr approximately 150,000). It contains 8.4% lipid and has an equilibrium density of 1.26 g/ml. This...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80459-4

    authors： Haunerland NH,Bowers WS

    更新日期：1986-01-29 00:00:00

  • Importance of phosphate contacts for sequence recognition by EcoRI restriction enzyme.

    abstract：:We have studied the importance of charge and hydrogen-bonding potential of the phosphodiester backbone for binding and cleavage by EcoRI restriction endonuclease. We used 12-mer oligodeoxynucleotide substrates with single substitutions of phosphates by chiral methylphosphonates at each position of the recognition sequ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)00645-9

    authors： Rosati O,Srivastava TK,Katti SB,Alves J

    更新日期：2002-07-05 00:00:00

  • Autocrine galectin-1 promotes collective cell migration of squamous cell carcinoma cells through up-regulation of distinct integrins.

    abstract：:We found that high galectin-1 (Gal-1) mRNA levels were associated with invasive squamous cell carcinoma (SCC) cells that expressed Snail, an epithelial-to-mesenchymal transition (EMT) regulator. Both Gal-1 overexpression and soluble Gal-1 treatment accelerated invasion and collective cell migration, along with activat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.10.152

    authors： Rizqiawan A,Tobiume K,Okui G,Yamamoto K,Shigeishi H,Ono S,Shimasue H,Takechi M,Higashikawa K,Kamata N

    更新日期：2013-11-29 00:00:00

  • Activation of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

    abstract：:Phosphatidylinositol 3-kinase (PI 3-kinase) was partially purified from rat liver cytosol and used to synthesize phosphatidylinositol 3,4,5-trisphosphate (PIP3), using phosphatidylinositol 4,5-bisphosphate (PIP2) as a substrate. Purified PIP3 (free of chromatographic oxalate) activated protein kinase C (PKC) in the pr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2016

    authors： Singh SS,Chauhan A,Brockerhoff H,Chauhan VP

    更新日期：1993-08-31 00:00:00

  • Intracellular [Ca2+] and K+ and Cl- efflux responses in submandibular cells of neonatal and adult rats.

    abstract：:The effects of graded doses (5 x 10(-8) to 10(-5)) acetylcholine on intracellular Ca2+ and on 86Rb and 36Cl efflux were compared in submandibular cell clusters of 1 and 7 day-old and adult rats. Initial Ca2+ peaks were similar at agonists concentrations lower than 10(-7) M but the release of Rb+ and Cl- were smaller i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)91353-r

    authors： Seagrave JC,Ramsey RC,Barker S,Martinez JR

    更新日期：1992-11-16 00:00:00