Abstract：
:We present here the biosynthesis of AgNps from the aqueous extract of H. thebaica fruit, and monitored through UV-Vis spectrophotometer. The functional group were characterized through ATR-FTIR spectroscopy, the particle size, morphologies and elemental composition of the nanoparticles were investigated by using TEM, FESEM and EDS respectively. The anti-proliferation activity of the synthesized AgNps was carried out using MTT assay on human prostate (PC3), breast (MCF7) and liver (HepG2) cancer cell lines. The anti-proliferation assay showed that the AgNps were able to inhibit the proliferation of the cancer cell lines in a dose depending manner. The effect was found more pronounced on prostate (IC50 2.6 mg/mL) followed by breast (IC50 4.8 mg/mL) and then liver cancer cell lines (IC50 6.8 mg/mL). The prepared AgNps were found to inhibit 99% growth of both E. coli and S. aureus after 24 h of incubation. The nanoparticles were used for the degradation of 4-nitrophenol (4-NP) and Congo red dyes (CR), which efficiently degrade CR, but make complex formation with 4-NP. Therefore, the AgNps synthesized from the aqueous fruit extract of H. thebaica have potential application in pharmacology and waste water treatment.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Bello BA,Khan SA,Khan JA,Syed FQ,Mirza MB,Shah L,Khan SBdoi
10.1016/j.bbrc.2017.06.136subject
Has Abstractpub_date
2017-08-26 00:00:00pages
889-894issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(17)31267-6journal_volume
490pub_type
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