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MARs mission update.

Abstract：

:Genes are organized as chromatin domains and positioned in the nucleus through regions of nuclear matrix association, termed MARs. Although well-studied, the mechanisms regulating expression of the beta-globin locus remain an enigma. Here, we show that certain MAR sequences of the beta-globin locus are conserved and reiterated throughout the genome in association with other genes of the hematopoietic lineage. Further, the density of the MARs within the beta-globin locus and the sharing of these sequences by the various members of this gene cluster suggest that they may provide critical gene regulatory components.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Walter WR,Singh GB,Krawetz SA

doi

10.1006/bbrc.1997.7939

subject

Has Abstract

pub_date

1998-01-14 00:00:00

pages

419-22

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)97939-0

journal_volume

242

pub_type

杂志文章

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