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A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm.

Abstract：

:Injection of DN-BR mRNA encoding a dominant negative type I receptor for bone morphogenetic protein 4 (BMP4) converted prospective ectoderm into neural tissue in Xenopus animal cap explants, in the absence of expression of mesodermal marker genes. The injected caps expressed a general neural marker NCAM and the forebrain marker opsin. Coinjection of wild-type BMP4 receptor mRNA completely reversed the neuralization by DN-BR. No expression of known neuralizing factors, i.e., noggin and follistatin, was detected in the DN-BR-injected animal caps. Furthermore, neuralization elicited by noggin or 3m, a LIM domain mutant of Xlim-1, was substantially inhibited by co-injection of BMP4 mRNA. Since BMP4 is expressed in the prospective ectoderm during gastrulation, our results suggest that the ventralizing factor BMP4 acts also as a physiological inhibitor of neuralization in the development of Xenopus ectoderm.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Xu RH,Kim J,Taira M,Zhan S,Sredni D,Kung HF

doi

10.1006/bbrc.1995.1958

subject

Has Abstract

pub_date

1995-07-06 00:00:00

pages

212-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X85719584

journal_volume

212

pub_type

杂志文章

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