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Restricted expression pattern of vegf-d in the adult and fetal mouse: high expression in the embryonic lung.

Abstract：

:Endothelial growth factors have become the target of intense research since the initial discovery of vascular endothelial growth factor (VEGF/VPF). At present, VEGF is established as a major inducer of angiogenesis in normal and pathological conditions. Recently several new members in the VEGF family have been described; VEGF-B/VRF, VEGF-C and VEGF-D. VEGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. We have here examined the expression pattern of vegf-d mRNA with in situ hybridization in developing and adult mice. This shows a restricted expression pattern, with high levels mainly in lung tissue. The expression in embryonic lung is upregulated prior to birth. Expression of vegf-d in other tissues, as well as in lung tissue of the E14 embryo, was either low or absent. This suggests that VEGF-D may be of special relevance for the vascularization of lung tissue during the last trimester of fetal development.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Farnebo F,Piehl F,Lagercrantz J

doi

10.1006/bbrc.1999.0562

subject

Has Abstract

pub_date

1999-04-21 00:00:00

pages

891-4

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)90562-4

journal_volume

257

pub_type

杂志文章

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