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Effect of herbal melanin on IL-8: a possible role of Toll-like receptor 4 (TLR4).

Abstract：

:The production of IL-8 can be induced by LPS via TLR4 signaling pathway. In this study, we tested the effect of a herbal melanin (HM) extract, from black cumin seeds (Nigella sativa L.), on IL-8 production. We used HM and LPS in parallel to induce IL-8 production by THP-I, PBMCs, and TLR4-transfected HEK293 cells. Both HM and LPS induced IL-8 mRNA expression and protein production in THP-1 and PBMCs. On applying similar treatment to HEK293 cells that express TLR4, MD2, and CD14, both HM and LPS significantly induced IL-8 protein production. We have also demonstrated that HM and LPS had identical effects in terms of IL-8 stimulation by HEK293 transfected with either TLR4 or MD2-CD14. Melanin extracted from N. sativa L. mimics the action of LPS in the induction of IL-8 by PBMC and the other used cell lines. Our results suggest that HM may share a signaling pathway with LPS that involves TLR4.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

El-Obeid A,Hassib A,Pontén F,Westermark B

doi

10.1016/j.bbrc.2006.04.035

subject

Has Abstract

pub_date

2006-06-16 00:00:00

pages

1200-6

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)00843-6

journal_volume

344

pub_type

杂志文章

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