The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1.

abstract：:DR4, a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor, is a key element in the extrinsic pathway of TRAIL/TRAIL receptor-related apoptosis that exerts a preferential toxic effect against tumor cells. However, TRAIL and DR4 are expressed in various normal cells, and recent studies indicate tha...

journal_title：Biochemical and biophysical research communications

authors： Kang MS,Lee SK,Park CS,Kang JH,Bae SH,Yu SL

更新日期：2008-11-14 00:00:00

abstract：:Treatment of platelet rich plasma (PRP) at pH 5 results in the precipitation of a protein kinase system. The protein kinase is associated with the platelet fraction and is capable of phosphorylation of several plasma proteins. Analysis of the 32P-labeled phosphoproteins by two dimensional gel electrophoresis showed th...

journal_title：Biochemical and biophysical research communications

authors： Galabru J,Krust B,Hovanessian AG

更新日期：1983-06-15 00:00:00

abstract：:Beta-catenin has essential roles in morphogenesis and human cancer, both as a subunit of adhesive complexes in the cell membrane and as a transcriptional coactivator in the Wnt signaling pathway. In addition, beta-catenin also has the ability to transport lymphoid enhancer binding factor-1 into the nucleus. In this st...

journal_title：Biochemical and biophysical research communications

authors： Hsu HT,Liu PC,Ku SY,Jung KC,Hong YR,Kao C,Wang C

更新日期：2006-05-12 00:00:00

abstract：:Myosin light chain kinase (MLCK) is a multifunctional regulatory protein of smooth muscle contraction [IUBMB Life 51 (2001) 337, for review]. The well-established mode for its regulation is to phosphorylate the 20 kDa myosin light chain (MLC 20) to activate myosin ATPase activity. MLCK exhibits myosin-binding activity...

journal_title：Biochemical and biophysical research communications

authors： Gao Y,Kawano K,Yoshiyama S,Kawamichi H,Wang X,Nakamura A,Kohama K

更新日期：2003-05-23 00:00:00

abstract：:The tissue targeting and rate of clearance of cobra venom factor (CVF) from the circulation was studied in mice by intravenous or intraperitoneal injection of radioiodinated CVF. In both modes of administrations, CVF was targeted mainly to liver. CVF injected directly into the blood was cleared from the circulation wi...

journal_title：Biochemical and biophysical research communications

authors： Fu Q,Satyaswaroop PG,Gowda DC

更新日期：1997-02-13 00:00:00

abstract：:The existence of cancer stem cells within the tumor could lead to cancer therapy resistance. TGFβ1 is considered as one of the most powerful players in the generation of CSCs through induction of epithelial-mesenchymal transition in different types of cancer including lung cancer, however, the detailed mechanisms by w...

journal_title：Biochemical and biophysical research communications

authors： Zhang F,Li T,Han L,Qin P,Wu Z,Xu B,Gao Q,Song Y

更新日期：2018-02-19 00:00:00

abstract：:v-Src activates gene expression mediated by serum response elements (SREs) and TPA response elements (TREs). v-Src-induced SRE- and TRE-mediated gene expressions are both dependent upon HaRas. Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that has been implicated in v-Src-initiated signals. We report...

journal_title：Biochemical and biophysical research communications

authors： Gupta R,Foster DA

更新日期：1994-12-15 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) is a calmodulin (CaM)-dependent enzyme, which generates the ubiquitous biological mediator nitric oxide. In this study, wild-type or mutant form of rat nNOS was overexpressed in a baculovirus/Sf9 insect cell system and examined for autophosphorylation. Incubation of purified wild-...

journal_title：Biochemical and biophysical research communications

authors： Watanabe Y,Terashima K,Hidaka H

更新日期：1996-02-15 00:00:00

abstract：:Circular RNA (circRNA) belongs to the non-coding RNA family and is involved in various human cancers, such as lung cancer and colorectal cancer. Nevertheless, whether circRNA expression is related to chronic lymphocytic leukemia (CLL) progression remains largely unclear. In our study, we investigated the role of circ-...

journal_title：Biochemical and biophysical research communications

authors： Xia L,Wu L,Bao J,Li Q,Chen X,Xia H,Xia R

更新日期：2018-09-03 00:00:00

abstract：:The effect of steroid chemical structure on steroid-lipid interaction is studied in sonicated dipalmitoyl phosphatidylcholine vesicles by steady-state and time-resolved fluorescence anisotropy techniques using diphenylhexatriene as probe. A large number of cholesterol derivatives and steroids, some of them being precu...

journal_title：Biochemical and biophysical research communications

authors： Vincent M,Gallay J

更新日期：1983-06-29 00:00:00

abstract：:Arctigenin is a bioactive constituent from dried seeds of Arctium lappa L., which was traditionally used as medicine. Arctigenin exhibits various bioactivities, but its effects on blood pressure regulation are still not widely studied. In this study, we investigated antihypertensive effects of arctigenin by long-term ...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Wang G,Yang M,Chen H,zhao Y,Yang S,Sun C

更新日期：2015-12-25 00:00:00

abstract：:Downregulation of the LATS1 tumour suppressor protein kinase contributes to tumour formation in mammals and flies. Strikingly, the tumour suppressor activity depends on the interaction with Dmob (Drosphila Mps1-One binder) in Drosophila melanogaster. Recently, human LATS1 was reported to interact with human MOB1 (hMOB...

journal_title：Biochemical and biophysical research communications

authors： Hergovich A,Schmitz D,Hemmings BA

更新日期：2006-06-23 00:00:00

abstract：:High affinity iron uptake in yeast is carried out by a multicomponent system formed by the ferroxidase Fet3p and the iron permease Ftr1p. The currently accepted model predicts that Fet3p and Ftr1p are functionally associated, however, a structural interaction between these two proteins has not been proven yet. The met...

journal_title：Biochemical and biophysical research communications

authors： Bonaccorsi di Patti MC,Miele R,Eugenia Schininà M,Barra D

更新日期：2005-07-29 00:00:00

abstract：:Prion protein (PrPc) is expressed in many tissues, both in human and animals. The scrapie isoform of PrPc has been shown to cause neurodegeneration. In other studies it has been demonstrated that overexpression of the PrP gene can result in nonneuronal tissue degradation. Little is known, however, about the normal fun...

journal_title：Biochemical and biophysical research communications

authors： Kniazeva M,Orman R,Terranova VP

更新日期：1997-05-08 00:00:00

abstract：:The lipase from Malassezia globosa (SMG1) was identified to be strictly specific for mono- and diacylglycerol but not triacylglycerol. The crystal structures of SMG1 were solved in the closed conformation, but they failed to provide direct evidence of factors responsible for this unique selectivity. To address this pr...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Gao C,Lan D,Yang B,Wang Y

更新日期：2012-07-27 00:00:00

abstract：:A new cleavage site, which is a post-translational modification, was found between residues His-154 and Ala-155 in alpha A-crystallin from the aged human lens. After trypsin digestion of alpha A-crystallin two peptides that include Asp-151 were obtained and have remarkable differences. That is, the stereo-configuratio...

journal_title：Biochemical and biophysical research communications

authors： Fujii N,Momose Y,Yamasaki M,Yamagaki T,Nakanishi H,Uemura T,Takita M,Ishii N

更新日期：1997-10-29 00:00:00

abstract：:Hsp90 and its co-chaperone Cdc37 are required for the activity of numerous eukaryotic protein kinases. c-Jun N-terminal kinases (JNKs) appear to be Hsp90-independent kinases, as their activity is unaffected by Hsp90 inhibition. It is currently unknown why some protein kinases are Hsp90- and Cdc37-dependent for their f...

journal_title：Biochemical and biophysical research communications

authors： Prince T,Matts RL

更新日期：2005-12-23 00:00:00

abstract：:Iron overload, as a risk factor for osteoporosis, can result in the up-regulation of Hepcidin, and Hepcidin knockout mice display defects in their bone microarchitecture. However, the molecular and genetic mechanisms underlying Hepcidin deficiency-derived bone loss remain unclear. Here, we show that hepcidin knockdown...

journal_title：Biochemical and biophysical research communications

authors： Jiang Y,Yan Y,Wang X,Zhu G,Xu YJ

更新日期：2016-07-15 00:00:00

abstract：:We have previously shown that sphingosine 1-phosphate (S1P) stimulates motility of human umbilical vein endothelial cells (HUVECs) (O.-H. Lee et al., Biochem. Biophys. Res. Commun. 264, 743-750, 1999). To investigate the molecular mechanisms by which S1P stimulates HUVEC motility, we examined tyrosine phosphorylation ...

journal_title：Biochemical and biophysical research communications

authors： Lee OH,Lee DJ,Kim YM,Kim YS,Kwon HJ,Kim KW,Kwon YG

更新日期：2000-02-05 00:00:00

abstract：:Targeted drug delivery has been an important issue for tumor therapy including photodynamic therapy (PDT). The purpose of our study is to increase the targeting efficiency of photosensitizer (PS) using folate-modified nanoparticles (NPs) to tumor site in vivo. Folate receptor is over-expressed on the surface of many h...

journal_title：Biochemical and biophysical research communications

authors： Son J,Yang SM,Yi G,Roh YJ,Park H,Park JM,Choi MG,Koo H

更新日期：2018-04-06 00:00:00

abstract：:Cysteine proteases have been identified in parasitic protozoa including the causative agent of Chagas' disease Trypanosoma cruzi. T. cruzi lysates subjected to substrate-containing SDS-polyacrylamide gel electrophoresis exhibit major bands of proteolytic activity in the 45-55 kDa molecular mass range (cruzipain activi...

journal_title：Biochemical and biophysical research communications

authors： Wiser MF,Lonsdale-Eccles JD,D'Alessandro A,Grab DJ

更新日期：1997-11-26 00:00:00

abstract：:Malaria, a disease accounting for more than one million deaths per year, is caused by intraerythrocytic growth of Plasmodia. Parasitemia may be blunted by suicidal erythrocyte death or eryptosis, which is characterized by cell shrinkage and phosphatidylserine exposure. Triggers of eryptosis include lead nitrate (Pb(NO...

journal_title：Biochemical and biophysical research communications

authors： Koka S,Huber SM,Boini KM,Lang C,Föller M,Lang F

更新日期：2007-11-23 00:00:00

abstract：:Excessive cellular cholesterol is transported to the liver by a pathway called 'reverse cholesterol transport.' Scavenger receptor class B, type I (SR-BI) mediates cholesterol uptake in the liver. Polyunsaturated fatty acids, known to activate peroxisome proliferator-activated receptor (PPAR), have been reported to in...

journal_title：Biochemical and biophysical research communications

authors： Malerød L,Sporstøl M,Juvet LK,Mousavi A,Gjøen T,Berg T

更新日期：2003-06-06 00:00:00

abstract：:The conversion of androgens to estrogens by CYP19 (cytochrome P450AROM, aromatase) is an important step in the mechanism of androgen action in the brain. CYP19 expression has been demonstrated in various animal species, but studies in human postnatal brain tissue are lacking. Therefore, we investigated CYP19 mRNA expr...

journal_title：Biochemical and biophysical research communications

authors： Stoffel-Wagner B,Watzka M,Steckelbroeck S,Schwaab R,Schramm J,Bidlingmaier F,Klingmüller D

更新日期：1998-03-27 00:00:00

abstract：:The growth of DU-145 human prostate carcinoma cells is reduced to 50% of control by 1 X 10(-6) M to 2 X 10(-6) M selenium and to 2% of control at 10(-4)M selenium. These cells show greater sensitivity to inhibition of growth or DNA synthesis by selenium than human W1-38 and HeLa cells and mouse mammary tumor cells. It...

journal_title：Biochemical and biophysical research communications

authors： Webber MM,Perez-Ripoll EA,James GT

更新日期：1985-07-31 00:00:00

abstract：:The spectrum of resting cytochrome c oxidase is modulated by valinomycin addition, which induces a red shift of the Soret band. The enzyme is known both to fluoresce and phosphorescence, effects which can be modulated by certain protein reagents and quenchers. Valinomycin had little effect upon fluorescence at 335 nm,...

journal_title：Biochemical and biophysical research communications

authors： Butko P,He J,Nicholls P

更新日期：1992-12-30 00:00:00

abstract：:To investigate the biological function of CKII, we have identified proteins that interact with the subunits of CKII using the yeast two-hybrid system. Here we report that SAG, an antioxidant protein containing Ring-H2 finger motif, is a cellular partner associating with the beta subunit of CKII. SAG does not interact ...

journal_title：Biochemical and biophysical research communications

authors： Son MY,Park JW,Kim YS,Kang SW,Marshak DR,Park W,Bae YS

更新日期：1999-10-05 00:00:00

abstract：:Vascular pericytes and smooth muscle cells surround many blood vessels of the body. Their primary roles include vessel stabilization and regulation of the blood flow. The high degree of heterogeneity among these cells is dictated by (1) differences in their developmental origin and (2) their location in the vascular b...

journal_title：Biochemical and biophysical research communications

authors： Halaidych OV,Mummery CL,Orlova VV

更新日期：2019-05-21 00:00:00

abstract：:The activity of the enzyme tyrosine aminotransferase and the synthesis of its specific mRNA were evaluated at different hours of the day in the liver of 3-, 12- and 24-month old BN rats. The enzyme activity has a circadian rhythm with a peak at midnight in 3- and 12-month old, which shifts to 03.00 hrs in 24-month old...

journal_title：Biochemical and biophysical research communications

authors： Servillo G,Della Fazia MA,Viola-Magni M

更新日期：1991-02-28 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma, co-activator 1 alpha(PGC1α) effectively induced the biosynthesis of the mitochondria and the energy metabolism, and also regulated the muscle fiber-type shift. Overexpression of PGC1α gene in mice led to higher oxidative muscle fiber composition in muscle. However,...

journal_title：Biochemical and biophysical research communications

authors： Ying F,Zhang L,Bu G,Xiong Y,Zuo B

更新日期：2016-11-25 00:00:00