Variation of tyrosine aminotransferase expression during the day in rats of different ages.

Abstract:

:The activity of the enzyme tyrosine aminotransferase and the synthesis of its specific mRNA were evaluated at different hours of the day in the liver of 3-, 12- and 24-month old BN rats. The enzyme activity has a circadian rhythm with a peak at midnight in 3- and 12-month old, which shifts to 03.00 hrs in 24-month old animals, in agreement with previous results. The expression of TATmRNA also changes during the day indicating circadian fluctuations which change with age. In 3-month old rats the TATmRNA peak is at 19.00 hrs, preceding that of the enzyme activity. In 12-month old rats the TATmRNA synthesis reaches a maximum at midnight and in 24-month old rats at 03.00 hrs. The results show that the circadian rhythm of tyrosine aminotransferase activity is due to a different gene expression throughout the day, which is influenced by age.

authors

Servillo G,Della Fazia MA,Viola-Magni M

doi

10.1016/s0006-291x(05)81206-9

subject

Has Abstract

pub_date

1991-02-28 00:00:00

pages

104-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)81206-9

journal_volume

175

pub_type

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