A protein kinase system from platelet rich plasma.

abstract：:To develop antibodies against the plasma membrane 3,3',5-triiodo-L-thyronine (T3) binding protein (M.W. 55,000), rabbits were immunized with formalin-fixed GH3 cells or highly purified plasma membranes from these cells. Antibodies were screened by immunoprecipitation using detergent solubilized N-bromoacetyl-[125I]T3-...

journal_title：Biochemical and biophysical research communications

authors： Hasumura S,Rossi B,Alderson R,Pastan I,Cheng S

更新日期：1984-11-14 00:00:00

abstract：:Whether mitochondrial Ca(2+) transport is rapid enough to respond to changes in cytosolic [Ca(2+)] ([Ca(2+)](c)) which occur during excitation-contraction coupling in the heart is controversial; different results wereobtained with different techniques and different species. In this study mitochondrial [Ca(2+)] ([Ca(2+...

journal_title：Biochemical and biophysical research communications

authors： Griffiths EJ

更新日期：1999-09-24 00:00:00

abstract：:Isocitrate dehydrogenase 1 (IDH1) mutations have been detected in gliomas and other tumors. Although IDH1 catalyzes the oxidative carboxylation of isocitrate to α-ketoglutarate (α-KG) in cytosol, mutated IDH1 proteins possess the ability to change α-KG into the oncometabolite D-2-hydroxyglutarate (D-2HG). Several mono...

journal_title：Biochemical and biophysical research communications

authors： Fujii Y,Ogasawara S,Oki H,Liu X,Kaneko MK,Takano S,Kato Y

更新日期：2015-10-30 00:00:00

abstract：:The vast majority of in vitro and in vivo studies did not find cancerogenic effects of exposure to electromagnetic fields (RF-EMF), i.e. emitted by mobile phones and base stations. Previously published results from a pilot study with carcinogen-treated mice, however, suggested tumor-promoting effects of RF-EMF (Tillma...

journal_title：Biochemical and biophysical research communications

authors： Lerchl A,Klose M,Grote K,Wilhelm AF,Spathmann O,Fiedler T,Streckert J,Hansen V,Clemens M

更新日期：2015-04-17 00:00:00

abstract：:We introduced a lentiviral vector containing the Sox11 gene into injured spinal cords of mice to evaluate the therapeutic potential of Sox11 in spinal cord injury. Sox11 markedly improved locomotor recovery after spinal cord injury and this recovery was accompanied by an up-regulation of Nestin/Doublecortin expression...

journal_title：Biochemical and biophysical research communications

authors： Guo Y,Liu S,Zhang X,Wang L,Zhang X,Hao A,Han A,Yang J

更新日期：2014-04-18 00:00:00

abstract：:Diabetes is a chronic disease that disrupts the balance between bone formation and bone desorption, which can lead to osteoporosis, increasing the risk of fracture. However, compared with osteoblasts, the biological effects of hyperglycemia on osteoclastogenesis remain to be elucidated. Therefore, we investigated the ...

journal_title：Biochemical and biophysical research communications

authors： Cai ZY,Yang B,Shi YX,Zhang WL,Liu F,Zhao W,Yang MW

更新日期：2018-09-05 00:00:00

abstract：:Opioid binding properties of Tyr-D-Ser-Gly-Phe-Leu-Thr-NH-NH-Gly-Mal (DSLET-Mal), a novel enkephalin-framed affinity label, was determined in rat brain membranes. In competition studies the ligand showed high affinity for the delta opioid sites, labelled by [(3)H][Ile(5,6)]deltorphin II (K(i) = 8 nM), whereas its bind...

journal_title：Biochemical and biophysical research communications

authors： Szatmári I,Orosz G,Medzihradszky K,Borsodi A

更新日期：1999-11-19 00:00:00

abstract：:Using affinity chromatography on immobilized transcortin of 125I-labeled, cholate-solubilized plasma membranes of human syncytiotrophoblast, a transcortin-binding protein with a minimal Mr of about 20 kDa has been isolated. It was found to be a sialoglycoprotein with an isoelectric point at pH 4.4 (about 5.0 after the...

journal_title：Biochemical and biophysical research communications

authors： Krupenko SA,Avvakumov GV,Strel'chyonok OA

更新日期：1991-06-14 00:00:00

abstract：:The present study demonstrates that human platelets possess a specific L-arginine transport system able to provide adequate amounts of L-arginine for endogenous nitric oxide production. L-arginine uptake takes place through a saturable high affinity carrier-mediated Na(+)-independent process which is significantly inh...

journal_title：Biochemical and biophysical research communications

authors： Vasta V,Meacci E,Farnararo M,Bruni P

更新日期：1995-01-26 00:00:00

abstract：:The effect of platelet release products on cytosolic calcium [( Ca++]i) was examined by monitoring the fluorescence of chick embryonic heart cells loaded with the fluorescent calcium indicator indo-1 AM. Cell free filtrate of platelet release products was obtained from rabbit platelets activated with thrombin or colla...

journal_title：Biochemical and biophysical research communications

authors： Chien WW,Mohabir R,Newman D,Leung LL,Clusin WT

更新日期：1990-08-16 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) cascades play an important role in regulation of AP-1 activity through the phosphorylation of distinct substrates. In the present study, we identified a novel protein, TMEM174, whose RNA transcripts are highly expressed in human kidney tissue. TMEM174 is comprised of 243 amino a...

journal_title：Biochemical and biophysical research communications

authors： Wang P,Sun B,Hao D,Zhang X,Shi T,Ma D

更新日期：2010-04-16 00:00:00

abstract：:One of the most important issues in stem cell research is to understand the regulatory mechanisms responsible for their differentiation. An extensive understanding of mechanism underlying the process of differentiation is crucial in order to prompt stem cells to perform a particular function after differentiation. To ...

journal_title：Biochemical and biophysical research communications

authors： Feng Z,Srivastava AS,Mishra R,Carrier E

更新日期：2004-11-26 00:00:00

abstract：:Chronic subcutaneous infusion of small doses (0.1 microgram/h) of ovine corticotropin-releasing factor (oCRF) into rats for 8 days resulted in differential alteration of proopiomelanocortin (POMC) mRNA levels in the individual pituitary lobes: In the anterior lobe POMC mRNA levels, quantitated by hybridisation using a...

journal_title：Biochemical and biophysical research communications

authors： Höllt V,Haarmann I

更新日期：1984-10-30 00:00:00

abstract：:A protein which inhibits the prophenoloxidase----phenoloxidase (EC 1.14.18.1) proteolytic activation in hemocyte extracts of Locusta migratoria was isolated from the plasma of the same insect and partially characterized. It shows a molecular weight of 14,000, an inhibiting activity toward the cascade system in the ins...

journal_title：Biochemical and biophysical research communications

authors： Brehélin M,Boigegrain RA,Drif L,Coletti-Previero MA

更新日期：1991-09-16 00:00:00

abstract：:Mitochondrial pyruvate carrier (MPC), composed of MPC1 and MPC2, can modulate pyruvate oxidation in mitochondrial and MPC1 expression correlates with poor prognosis of multiple cancers. Here, we reported that MPC1 is acetylated and its main acetylation sites are: K45 and K46. Sirt3 binds to and deacetylates MPC1. High...

journal_title：Biochemical and biophysical research communications

authors： Liang L,Li Q,Huang L,Li D,Li X

更新日期：2015-12-25 00:00:00

abstract：:Vascular degeneration appears to play crucial roles in producing many vascular malfunctions (1-3). In order to identify specific inducers of programmed death in vascular endothelial cells (VEC), examinations were made of the effects of substances that are known to affect the vascular system by using VEC in culture (4,...

journal_title：Biochemical and biophysical research communications

authors： Araki S,Ishida T,Yamamoto T,Kaji K,Hayashi H

更新日期：1993-01-15 00:00:00

abstract：:Cholestasis and hepatitis can cause continuous liver damage that may ultimately result in liver fibrosis. In a previous study, we demonstrated that microRNA-29a (miR-29a) protects against liver fibrosis. Toll-like receptor 2 (TLR2) and TLR4 are pattern recognition receptors of bacterial lipoprotein and lipopolysacchar...

journal_title：Biochemical and biophysical research communications

authors： Lin YC,Wang FS,Yang YL,Chuang YT,Huang YH

更新日期：2018-02-12 00:00:00

abstract：:Quercetin is the most abundant flavonoid and is assumed to have protective roles against the pathogenesis of multiple diseases associated with oxidative stress. In the present study, we investigated the molecular mechanisms by which quercetin affects adipogenesis and apoptosis in 3T3-L1 cells. The exposure of 3T3-L1 p...

journal_title：Biochemical and biophysical research communications

authors： Ahn J,Lee H,Kim S,Park J,Ha T

更新日期：2008-09-05 00:00:00

abstract：:Pigment epithelial-derived factor (PEDF) is a multifunctional secreted glycoprotein, which could protect against hypoxia-induced cell death related to its anti-oxidative effect in cultured cardiomyocytes. However, the pathway mediating this cytoprotective process has not been fully established. Here we confirmed that ...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Zhang Y,Lu P,Zhang H,Li Y,Dong H,Zhang Z

更新日期：2015-09-25 00:00:00

abstract：:The von Hippel-Lindau (VHL) is a known tumor suppressor that binds to alpha-subunits of hypoxia-inducible factors and induces ubiquitin-mediated degradation of the protein in an oxygen-dependent manner. VHL is also involved in the regulation of tumor angiogenesis, glycolysis, cell cycle regulation, and apoptosis. In t...

journal_title：Biochemical and biophysical research communications

authors： Kim M,Yan Y,Lee K,Sgagias M,Cowan KH

更新日期：2004-07-30 00:00:00

abstract：:Adult stem cells provide a promising alternative for the treatment of decompensated liver cirrhosis. Our previous study showed that peripheral blood monocytes (PBMCs) from decompensated liver cirrhosis could differentiate into hepatocyte-like cells in vitro. We here aimed to investigate the differential potential of t...

journal_title：Biochemical and biophysical research communications

authors： Yan L,Han Y,Wang J,Liu J,He Y,Wang H,Fan D

更新日期：2008-07-11 00:00:00

abstract：BACKGROUND/AIMS:We have previously reported that the application of sphingomyelin-based liposomes (SM-L) to a three-dimensional cultured skin model increase the content of ceramides NS, NP, AS and AP. However, the mechanism responsible for these increased ceramide levels was not identified. METHODS:SM-L and sphingomye...

journal_title：Biochemical and biophysical research communications

authors： Itaya Y,Tokudome Y

更新日期：2016-04-22 00:00:00

abstract：:Gliomas are the leading cause of death among adults with primary brain malignancies. Treatment for malignant gliomas remains limited, and targeted therapies have been incompletely explored. Nuclear factor erythroid 2-related factor 2 (Nrf2), a key transcription regulator for antioxidant and detoxification enzymes, is ...

journal_title：Biochemical and biophysical research communications

authors： Jia Y,Wang H,Wang Q,Ding H,Wu H,Pan H

更新日期：2016-01-15 00:00:00

abstract：:The objective was to investigate whether a graphene coating could improve the surface bioactivity of a cobalt-chromium-molybdenum-based alloy (CoCrMo). Graphene was produced by chemical vapor deposition and transferred to the surface of the CoCrMo alloy using an improved wet transfer approach. The morphology of the sa...

journal_title：Biochemical and biophysical research communications

authors： Zhang Q,Li K,Yan J,Wang Z,Wu Q,Bi L,Yang M,Han Y

更新日期：2018-03-18 00:00:00

abstract：:To better understand the mechanism of interactions between G-protein-coupled melatonin receptors and their ligands, our previously reported homology model of human MT2 receptor with docked 2-iodomelatonin was further refined and used to select residues within TM3, TM6, and TM7 potentially important for receptor-ligand...

journal_title：Biochemical and biophysical research communications

authors： Mazna P,Berka K,Jelinkova I,Balik A,Svoboda P,Obsilova V,Obsil T,Teisinger J

更新日期：2005-07-08 00:00:00

abstract：:Myocardium of mammals contains a wide range of isoforms of proteins that provides contractile function of the heart. These are two isoforms of ventricular and two of atrial myosin, α- and β-tropomyosin, and two isoforms of α-actin: cardiac and skeletal. We believe that the difference in the amino acid sequence of α-ac...

journal_title：Biochemical and biophysical research communications

authors： Shchepkin DV,Nikitina LV,Bershitsky SY,Kopylova GV

更新日期：2017-08-19 00:00:00

abstract：:Lipoproteins are important biological components. However, they have few convenient fluorescent labelling probes currently reported, and their physiological reliability can be questioned. We compared the association of two fluorescent cholesterol derivatives, 22-nitrobenzoxadiazole-cholesterol (NBD-Chol) and 21-methyl...

journal_title：Biochemical and biophysical research communications

authors： Gaibelet G,Tercé F,Bertrand-Michel J,Allart S,Azalbert V,Lecompte MF,Collet X,Orlowski S

更新日期：2013-11-01 00:00:00

abstract：:Tyrosine kinase inhibitors targeting the BCR-ABL oncoprotein in chronic myeloid leukemia (CML) are remarkably effective inducing deep molecular remission in most patients. However, they are less effective to eradicate the leukemic stem cells (LSC), resulting in disease persistence. Therefore, there is great need to de...

journal_title：Biochemical and biophysical research communications

authors： Dolinska M,Piccini A,Wong WM,Gelali E,Johansson AS,Klang J,Xiao P,Yektaei-Karin E,Strömberg UO,Mustjoki S,Stenke L,Ekblom M,Qian H

更新日期：2017-08-19 00:00:00

abstract：:Cell adhesion molecules act as tumor suppressors primarily by cell attachment activity, but additional mechanisms modifying signal transduction are suggested in some cases. Cell adhesion molecule 1 (CADM1), a membrane-spanning immunoglobulin superfamily, mediates intercellular adhesion by trans-homophilic interaction ...

journal_title：Biochemical and biophysical research communications

authors： Tsuboi Y,Oyama M,Kozuka-Hata H,Ito A,Matsubara D,Murakami Y

更新日期：2020-08-27 00:00:00

abstract：:Membrane protein solubilized by octyl-beta-D-glucopyranoside in the presence of dispersed phospholipid was incubated with bath-sonicated liposomes and additional detergent. The proteoliposomes formed on dilution showed transport and exchange properties consistent with a reconstitution of phosphate:sugar 6-phosphate an...

journal_title：Biochemical and biophysical research communications

authors： Ambudkar SV,Maloney PC

更新日期：1985-06-14 00:00:00