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Human TMEM174 that is highly expressed in kidney tissue activates AP-1 and promotes cell proliferation.

Abstract：

:Mitogen-activated protein kinase (MAPK) cascades play an important role in regulation of AP-1 activity through the phosphorylation of distinct substrates. In the present study, we identified a novel protein, TMEM174, whose RNA transcripts are highly expressed in human kidney tissue. TMEM174 is comprised of 243 amino acids, and contains two predicted transmembrane helices which determine its subcellular localization in endoplasmic reticulum and influences its functions. Over-expression of TMME174 enhanced the transcriptional activity of AP-1 and promoted cell proliferation, whereas the truncated mutant TMEM174DeltaTM without the transmembrane regions did not retain these functions. The possible mechanism of activation of AP-1 by TMEM174 was further examined. Our results suggest the potential role of TMEM174 in renal development and physiological function.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wang P,Sun B,Hao D,Zhang X,Shi T,Ma D

doi

10.1016/j.bbrc.2010.03.109

subject

Has Abstract

pub_date

2010-04-16 00:00:00

pages

993-9

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)00573-5

journal_volume

394

pub_type

杂志文章

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