当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > A novel protein, MUDENG, induces cell death in cytotoxic T cells.

A novel protein, MUDENG, induces cell death in cytotoxic T cells.

Abstract：

:A screening system comprised of a randomized hybrid-ribozyme library has previously been used to identify pro-death genes in Fas-mediated apoptosis, and short sequence information of candidate genes from this system was previously reported by Kawasaki and Taira [H. Kawasaki, K. Taira, A functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme libraries, Nucleic Acids Res. 30 (2002) 3609-3614]. In this study, we have cloned the full-length of the candidate's open reading frames and found that one of the candidates, referred to as MUDENG (Mu-2 related death-inducing gene), which is composed of 490 amino acids that contain the adaptin domain found in the mu2 subunit of APs related to clathrin-mediated endocytosis, is able to induce cell death by itself. Ectopic expression of MUDENG induced cell death in Jurkat T cells and HeLa cells. In addition, when MUDENG expression was evaluated by immnuohistochemical staining, it was found in most tissues, including the intestine and testis. Furthermore, MUDENG appears to be evolutionary conserved from mammals to amphibians, suggesting that it may have a common role in cell death. Taken together, these results suggest that MUDENG is likely to play an important role in cell death in various tissues.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lee MR,Shin JN,Moon AR,Park SY,Hong G,Lee MJ,Yun CW,Seol DW,Piya S,Bae J,Oh JW,Kim TH

doi

10.1016/j.bbrc.2008.03.139

subject

Has Abstract

pub_date

2008-06-06 00:00:00

pages

504-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)00617-7

journal_volume

370

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Two lutein molecules in LHCII have different conformations and functions: Insights into the molecular mechanism of thermal dissipation in plants.

    abstract：:When LHCII forms aggregates, the internal conformational changes will result in chlorophyll fluorescence quenching. Uncovering the molecular mechanism of this phenomenon will help us to understand how plants dissipate the excess excitation energy through non-photochemical quenching (NPQ) process. The crystal structure...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.01.172

    authors： Yan H,Zhang P,Wang C,Liu Z,Chang W

    更新日期：2007-04-06 00:00:00

  • Is the idea of a fast block to polyspermy based on artifact?

    abstract：:This purpose of this review is to look at the experimental evidence, both kinetic and electrophysiological, that led to the hypothesis of a fast electrical block to polyspermy in sea urchin eggs. The idea of a fast partial block, forwarded in the 1950's, that would reduce the receptivity of the egg surface by 1/20th f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2014.03.157

    authors： Dale B

    更新日期：2014-08-01 00:00:00

  • Rapid isolation of G alpha 13 from bovine brain membranes: supportive effect of ethylene glycol.

    abstract：:G13 belongs to the G12-subfamily of heterotrimeric regulatory G-proteins. Employing specific antibodies, we isolated G alpha 13 from bovine brain by a four-step purification protocol combining conventional and affinity chromatography. The use of ethylene glycol as a protective agent influenced the elution properties o...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2535

    authors： Harhammer R,Nürnberg B,Spicher K,Schultz G

    更新日期：1994-10-28 00:00:00

  • Diversity within the JMJD2 histone demethylase family.

    abstract：:JMJD2A-D belong to the JmjC domain-containing family of histone demethylases. JMJD2D is the most structurally divergent JMJD2 protein as it lacks the PHD and Tudor domains present in JMJD2A-C. Here, we systematically analyzed the histone demethylase specificity of JMJD2 proteins in vivo. We found that JMJD2A and C dem...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.147

    authors： Shin S,Janknecht R

    更新日期：2007-02-23 00:00:00

  • VEGF promotes tumorigenesis and angiogenesis of human glioblastoma stem cells.

    abstract：:There is increasing evidence for the presence of cancer stem cells (CSCs) in malignant brain tumors, and these CSCs may play a pivotal role in tumor initiation, growth, and recurrence. Vascular endothelial growth factor (VEGF) promotes the proliferation of vascular endothelial cells (VECs) and the neurogenesis of neur...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.06.094

    authors： Oka N,Soeda A,Inagaki A,Onodera M,Maruyama H,Hara A,Kunisada T,Mori H,Iwama T

    更新日期：2007-08-31 00:00:00

  • Metabolic depletion of sphingolipids enhances the mobility of the human serotonin1A receptor.

    abstract：:Sphingolipids are essential components of eukaryotic cell membranes. We recently showed that the function of the serotonin(1A) receptor is impaired upon metabolic depletion of sphingolipids using fumonisin B(1) (FB(1)), a specific inhibitor of ceramide synthase. Serotonin(1A) receptors belong to the family of G-protei...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.06.127

    authors： Ganguly S,Paila YD,Chattopadhyay A

    更新日期：2011-07-22 00:00:00

  • Hypertonic induction of COX2 expression requires TonEBP/NFAT5 in renal epithelial cells.

    abstract：:TonEBP/NFAT5 transcription factor is a master regulator of genes involved in osmoprotection. Cyclooxygenase 2 (COX2) has been reported to be a cytoprotective molecule in the inner renal medulla, where cells are physiologically exposed to the highest osmolality of the body. Our aim was to study whether COX2 expression ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.12.189

    authors： Favale NO,Casali CI,Lepera LG,Pescio LG,Fernández-Tome MC

    更新日期：2009-04-10 00:00:00

  • Interaction between cytochrome P450 2B1 and cytochrome bs: inhibition by synthetic peptides indicates a role for P450 residues Lys-122 and Arg-125.

    abstract：:Binding of cytochrome b5 to rat cytochrome P450 2B1 was inhibited (by 75%) by a synthetic peptide corresponding to P450 residues 116-134. The role of Lys-122 and Arg-125 were evaluated using peptides in which one or both of these basic residues were replaced with Glu. The Lys-122 substitution nearly abolished while th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1817

    authors： Omata Y,Sakamoto H,Robinson RC,Pincus MR,Friedman FK

    更新日期：1994-06-30 00:00:00

  • Osteopontin attenuates acute gastrointestinal graft-versus-host disease by preventing apoptosis of intestinal epithelial cells.

    abstract：BACKGROUND AND AIMS:Acute graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation, which often targets gastrointestinal (GI) tract. Osteopontin (OPN) plays an important physiological role in the efficient development of Th1 immune responses and cell survival by ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.02.047

    authors： Kawakami K,Minami N,Matsuura M,Iida T,Toyonaga T,Nagaishi K,Arimura Y,Fujimiya M,Uede T,Nakase H

    更新日期：2017-04-01 00:00:00

  • Butein, a specific protein tyrosine kinase inhibitor.

    abstract：:Butein, a plant polyphenol, was shown to be a specific protein tyrosine kinase inhibitor. This compound inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50 = 65 microM) and p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8452

    authors： Yang EB,Zhang K,Cheng LY,Mack P

    更新日期：1998-04-17 00:00:00

  • Epicubenol and Ferruginol induce DC from human monocytes and differentiate IL-10-producing regulatory T cells in vitro.

    abstract：:Epicubenol and 19-hydroxyferruginol (Ferruginol) are sesquiterpenes isolated from the black heartwood of Cryptomeria japonica. Dendritic cells (DC) are specialized antigen-presenting cells that monitor the antigenic environment and activate naïve T cells. The role of DC is not only to sense danger but also to tolerize...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.09.110

    authors： Takei M,Umeyama A,Arihara S

    更新日期：2005-11-18 00:00:00

  • WITHDRAWN: Expression of p53, p63, and p73 isoforms in squamous cell carcinoma and adenocarcinoma of esophagus☆,☆☆

    abstract：:This article has been withdrawn consistent with Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). The Publisher apologizes for any inconvenience this may cause. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.08.084

    authors： Cui R,He J,Mei R,de Fromentel CC,Martel-Planche G,Taniere P,Hainaut P

    更新日期：2005-08-22 00:00:00

  • Long noncoding RNA SOX2-OT facilitates prostate cancer cell proliferation and migration via miR-369-3p/CFL2 axis.

    abstract：:Accepted as crucial participators in human malignancies, long noncoding RNAs (lncRNAs) have been proven to exert significant function on the complicated processes of cancer progression. Although existing investigations have revealed the oncogenic role of lncRNA SOX2 overlapping transcript (SOX2-OT) in different kinds ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.09.108

    authors： Wo Q,Zhang D,Hu L,Lyu J,Xiang F,Zheng W,Shou J,Qi X

    更新日期：2019-12-10 00:00:00

  • qDNase assay: A quantitative method for real-time assessment of DNase activity on coated surfaces.

    abstract：:DNase coatings show great potential to prevent biofilm formation in various applications of the medical implant, food and marine industry. However, straightforward and quantitative methods to characterize the enzymatic activity of these coatings are currently not available. We here introduce the qDNase assay, a quanti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.10.050

    authors： Van der Gucht M,Aktan MK,Hendrix H,Velde GV,Paeshuyse J,Braem A,Lavigne R

    更新日期：2021-01-01 00:00:00

  • Homology-modeled ligand-binding domains of medaka estrogen receptors and androgen receptors: a model system for the study of reproduction.

    abstract：:Estrogen and androgen and their receptors play critical roles in physiological processes such as sexual differentiation and development. Using the available structural models for the human estrogen receptors alpha and beta and androgen receptor as templates, we designed in silico agonist and antagonist models of medak...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.01.047

    authors： Cui J,Shen X,Yan Z,Zhao H,Nagahama Y

    更新日期：2009-02-27 00:00:00

  • Enhancement of endothelial cell migration by constitutively active LPA(1)-expressing tumor cells.

    abstract：:Lysophosphatidic acid (LPA) receptors belong to G protein-coupled transmembrane receptors (LPA receptors; LPA(1) to LPA(6)). They indicate a variety of cellular response by the interaction with LPA, including cell proliferation, migration and differentiation. Recently, we have reported that constitutive active mutated...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.05.012

    authors： Kitayoshi M,Kato K,Tanabe E,Yoshikawa K,Fukui R,Fukushima N,Tsujiuchi T

    更新日期：2012-06-01 00:00:00

  • Translationally controlled tumor protein is a novel heat shock protein with chaperone-like activity.

    abstract：:Translationally controlled tumor protein (TCTP) is often designated as a stress-related protein because of its highly regulated expression in stress conditions. Following a thermal shock, TCTP expression is highly upregulated in a variety of cells. However, at present it is not known whether this upregulation has any ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.06.028

    authors： Gnanasekar M,Dakshinamoorthy G,Ramaswamy K

    更新日期：2009-08-21 00:00:00

  • TFDP3 inhibits E2F1-induced, p53-mediated apoptosis.

    abstract：:By dimerizing with E2F proteins, TFDP has profound influence on cellular E2F activities. While TFDP1 and 2 enhance the DNA binding and the transcriptional activity of E2F, the newly identified member of the DP family, TFDP3 primarily functions as a negative regulator. To further characterize the inhibitory property of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.06.128

    authors： Tian C,Lv D,Qiao H,Zhang J,Yin YH,Qian XP,Wang YP,Zhang Y,Chen WF

    更新日期：2007-09-14 00:00:00

  • Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A.

    abstract：:To determine whether the two domains of hepatitis C virus (HCV) NS3 and the NS4A interact with each other to regulate the RNA unwinding activity, this study compares the RNA unwinding, ATPase and RNA binding activities of three forms of NS3 proteins--the NS3H protein, containing only the helicase domain, the full-leng...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.03.032

    authors： Kuang WF,Lin YC,Jean F,Huang YW,Tai CL,Chen DS,Chen PJ,Hwang LH

    更新日期：2004-04-23 00:00:00

  • Analysis of human terminal deoxynucleotidyl transferase cDNA expressible in mammalian cells.

    abstract：:Human Molt3 cDNA library was constructed using pcD vector system which permits the expression of cDNA inserts in mammalian cells. Nearly full-length human terminal deoxynucleotidyltransferase (TdT) cDNA was cloned using a fragment of bovine TdT cDNA as a probe. The human TdT cDNA contains an open reading frame of 1,55...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80493-x

    authors： Koiwai O,Kaneda T,Morishita R

    更新日期：1987-04-14 00:00:00

  • Nuclear Overhauser effects as probes of peptide structure. A diagnostic for left-handed helical conformations.

    abstract：:The conformational dependence of the interresidue interproton distances in peptides, C alpha H ... Ni + 1 H and NiH ... Ni + 1 H, have been used to identify zones of sterically allowed phi, psi space, where both distances are less than 3A and expected to yield nuclear Overhauser effects (NOEs). L-residues in left-hand...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)90501-8

    authors： Ramakrishnan C,Sukumar M,Balaram P

    更新日期：1987-12-31 00:00:00

  • Structure-based development of pyridoxal propionate derivatives as specific inhibitors of cathepsin K in vitro and in vivo.

    abstract：:We found that pyridoxal phosphate shows considerable inhibition of cathepsins. CLIK-071, in which the phosphate ester of position 3 of pyridoxal phosphate was replaced by propionate, strongly inhibited cathepsin B. Three new types of synthetic pyridoxal propionate derivatives showing specific inhibition of cathepsin K...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1953

    authors： Katunuma N,Matsui A,Inubushi T,Murata E,Kakegawa H,Ohba Y,Turk D,Turk V,Tada Y,Asao T

    更新日期：2000-01-27 00:00:00

  • Combination of the chemotherapeutic agent 5-fluorouracil with an inhibitor of its catabolism results in increased micronucleus induction.

    abstract：:The rate limiting step in 5-fluorouracil catabolism is catalyzed by the enzyme dihydropyrimidine dehydrogenase. Since degradation of 5-fluorouracil decreases its efficacy in chemotherapy, the inhibition of its catabolism is a promising tool. We investigated the formation of micronuclei in vitro in mouse L5178Y cells. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2299

    authors： Stopper H,Kühnel A,Podschun B

    更新日期：1994-09-15 00:00:00

  • CYLD, a deubiquitinase specific for lysine63-linked polyubiquitins, accumulates at the postsynaptic density in an activity-dependent manner.

    abstract：:Polyubiquitin chains on proteins flag them for distinct fates depending on the type of polyubiquitin linkage. While lysine48-linked polyubiquitination directs proteins to proteasomal degradation, lysine63-linked polyubiquitination promotes different protein trafficking and is involved in autophagy. Here we show that p...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.10.131

    authors： Dosemeci A,Thein S,Yang Y,Reese TS,Tao-Cheng JH

    更新日期：2013-01-04 00:00:00

  • Identification and characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene.

    abstract：:As part of an effort to identify genes potentially involved in the Down Syndrome pathogenesis, in this paper we report the identification and characterization of a new human gene (named SH3BGRL), which shows a high homology to the SH3BGR gene, previously mapped to the Down Syndrome region of chromosome 21. The SH3BGRL...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8763

    authors： Egeo A,Mazzocco M,Arrigo P,Vidal-Taboada JM,Oliva R,Pirola B,Giglio S,Rasore-Quartino A,Scartezzini P

    更新日期：1998-06-18 00:00:00

  • Generation of 2,3,7,8-TCDD-metabolizing enzyme by modifying rat CYP1A1 through site-directed mutagenesis.

    abstract：:Polychlorinated dibenzo-p-dioxins (PCDDs) are known as g environmental contaminants on account of the extreme toxicity. Among these compounds, 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TetraCDD) is regarded as the most toxic one. The extremely high toxicity of 2,3,7,8-TetraCDD is based on its high affinity for Ah r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01439-6

    authors： Shinkyo R,Sakaki T,Takita T,Ohta M,Inouye K

    更新日期：2003-08-29 00:00:00

  • Ancient DNA in human bone remains from Pompeii archaeological site.

    abstract：:aDNA extraction and amplification procedures have been optimized for Pompeian human bone remains whose diagenesis has been determined by histological analysis. Single copy genes amplification (X and Y amelogenin loci and Y specific alphoid repeat sequences) have been performed and compared with anthropometric data on ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8881

    authors： Cipollaro M,Di Bernardo G,Galano G,Galderisi U,Guarino F,Angelini F,Cascino A

    更新日期：1998-06-29 00:00:00

  • Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells.

    abstract：:Thioredoxin reductase 1 (TrxR1) is a selenocysteine-containing redox-active enzyme that is thought to be important during carcinogenesis. We have recently shown that treatment with statins, HMGCoA reductase inhibitors, reduces the levels of TrxR1 in liver of both rat and human. The reduced TrxR1 levels were correlated...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.11.007

    authors： Ekström L,Johansson M,Monostory K,Rundlöf AK,Arnér ES,Björkhem-Bergman L

    更新日期：2013-01-04 00:00:00

  • Cloning and characterization of the 5'-flanking region of the Ehox gene.

    abstract：:The paired-like homeobox-containing gene Ehox plays a role in embryonic stem cell differentiation and is highly expressed in the developing placenta and thymus. To understand the mechanisms of regulation of Ehox gene expression, the 5'-flanking region of the Ehox gene was isolated from a mouse BAC library. 5'-RACE ana...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.12.176

    authors： Lee WK,Kim YM,Malik N,Ma C,Westphal H

    更新日期：2006-03-03 00:00:00

  • Improved chemoradiation treatment using trifluridine in human colorectal cancer cells in vitro.

    abstract：:We aimed to assess the combined effect of trifluridine (FTD) and ionizing radiation (IR) on colorectal cancer cells in vitro. Colorectal cancer cells, HT-29, HCT-15, and HCT 116, showing low, medium, and high sensitivity to IR, respectively, were treated with the combinations of FTD and IR, and evaluated by the clonog...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.10.044

    authors： Matsuoka K,Kobunai T,Nukatsuka M,Takechi T

    更新日期：2017-12-09 00:00:00