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Identification of a lysophosphatidylserine receptor on mast cells.

Abstract：

:Lysophosphatidyl-L-serine (lysoPS) is thought to be an immunological regulator because it dramatically augments the degranulation of rat peritoneal mast cells (RPMCs). This stimulatory effect may be mediated by a lysoPS receptor, but its molecule has not been identified yet. During a ligand fishing study for the orphan G-protein-coupled receptor 34 (GPR34), we found that lysoPS caused a dose-dependent inhibition of forskolin-stimulated cAMP accumulation in human GPR34-expressing Chinese hamster ovary (CHO/hGPR34) cells. The CHO/hGPR34 cells were unresponsive to other structurally related phospholipids examined. Quantitative real-time-PCR demonstrated that mRNAs of GPR34 are particularly abundant in mast cells. The effective lysoPS concentration for RPMC degranulation was similar to that required for GPR34 activation, and the structural requirement of lysoPS for RPMC degranulation was in good agreement with that observed in CHO/hGPR34 cells. These results suggest that GPR34 is the functional mast cell lysoPS receptor.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sugo T,Tachimoto H,Chikatsu T,Murakami Y,Kikukawa Y,Sato S,Kikuchi K,Nagi T,Harada M,Ogi K,Ebisawa M,Mori M

doi

10.1016/j.bbrc.2006.01.069

subject

Has Abstract

pub_date

2006-03-24 00:00:00

pages

1078-87

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)00158-6

journal_volume

341

pub_type

杂志文章

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