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Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: teleocidin and debromoaplysiatoxin.

Abstract：

:The new potent tumor promoters teleocidin and debromoaplysiatoxin , which are structurally unrelated to phorbol esters, activate Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). The concentrations of 12-O-tetradecanoylphorbol-13-acetate, teleocidin and debromoaplysiatoxin for half-maximum activation of protein kinase C were found to be approximately 3 ng/ml, 40 ng/ml and 400 ng/ml, respectively. These three types of tumor promoters bind to protein kinase C, and appear to exhibit their pleiotropic actions through activation of this enzyme.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fujiki H,Tanaka Y,Miyake R,Kikkawa U,Nishizuka Y,Sugimura T

doi

10.1016/0006-291x(84)91259-2

subject

Has Abstract

pub_date

1984-04-30 00:00:00

pages

339-43

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(84)91259-2

journal_volume

120

pub_type

杂志文章

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