Expression and characterization of the olfactomedin domain of human myocilin.

abstract：:Jasmonates are plant lipid-derived oxylipins that act as key signaling compounds in plant immunity, germination, and development. Although some physiological activities of natural jasmonates in mammalian cells have been investigated, their anti-inflammatory actions in mammalian cells remain unclear. Here, we investiga...

journal_title：Biochemical and biophysical research communications

authors： Taki-Nakano N,Kotera J,Ohta H

更新日期：2016-05-13 00:00:00

abstract：:The homeodomain transcription factor Pdx1 is essential for pancreas formation and functions in pancreatic islets cells to regulate genes involved in maintenance of glucose homeostasis. In order to investigate a role for Pdx1 in intestinal cells, we analyzed the functions and networks associated with genes differential...

journal_title：Biochemical and biophysical research communications

authors： Chen C,Leavitt T,Sibley E

更新日期：2012-08-03 00:00:00

abstract：:Angiogenesis is a fundamental process by which new blood vessels are formed. The angiogenesis process is induced by several growth factors. Among them angiogenin is the most potent blood vessel inducer known. In this paper, we have investigated the effect of green tea polyphenols, mainly the catechins, on an angiogeni...

journal_title：Biochemical and biophysical research communications

authors： Maiti TK,Chatterjee J,Dasgupta S

更新日期：2003-08-15 00:00:00

abstract：:The binding of the leucocyte adhesion molecule L-selectin has been investigated toward several structurally defined lipid-linked oligosaccharides immobilized on silica gel chromatograms or plastic wells. In both assay systems the 3'-sulphated Le(a)/Le(x) type tetrasaccharides [formula: see text] were more strongly bou...

journal_title：Biochemical and biophysical research communications

authors： Green PJ,Tamatani T,Watanabe T,Miyasaka M,Hasegawa A,Kiso M,Yuen CT,Stoll MS,Feizi T

更新日期：1992-10-15 00:00:00

abstract：:Blebbistatin is a novel 1-phenyl-2-pyrrolidinone derivative capable of inhibiting non-muscle myosin II activity with a high degree of specificity. We examined the effects of blebbistatin on pancreatic adenocarcinoma cellular migration, invasion, adhesion, and spreading. Blebbistatin dose-dependently inhibited cellular...

journal_title：Biochemical and biophysical research communications

authors： Duxbury MS,Ashley SW,Whang EE

更新日期：2004-01-23 00:00:00

abstract：:Gaucher disease (GD) is the most common lysosomal storage disorder (LSD) and is divided into three phenotypes, I, II, and III. Type I is the most prevalent form and has its onset in adulthood. The degree of endoplasmic reticulum (ER) stress is one of the factors that determine GD severity. It has recently been reporte...

journal_title：Biochemical and biophysical research communications

authors： Lee YJ,Kim SJ,Heo TH

更新日期：2011-09-23 00:00:00

abstract：:Regulation of the retina-specific expression of the interphotoreceptor retinoid-binding protein (IRBP) gene in transgenic mice requires sequences between nucleotide (nt) -156 and +19. DNAse I footprinting and electrophoretic mobility shift assays identified a region between nt -69 and -40 that interacts with some nucl...

journal_title：Biochemical and biophysical research communications

authors： Liou GI,Matragoon S,Overbeek PA,Fei Y

更新日期：1994-09-30 00:00:00

abstract：:Orally ingested botulinum toxin enters the circulatory system and eventually reaches the peripheral nerves, where it elicits a response of neurological dysfunction. In this study, we report the important findings concerning the mechanism of Clostridium botulinum type C progenitor toxin (C16S) endocytic mechanism. C16S...

journal_title：Biochemical and biophysical research communications

authors： Nishikawa A,Uotsu N,Arimitsu H,Lee JC,Miura Y,Fujinaga Y,Nakada H,Watanabe T,Ohyama T,Sakano Y,Oguma K

更新日期：2004-06-25 00:00:00

abstract：:Laser Doppler velocimetry measurements on purple membrane suspensions from Halobacterium halobium showed a linear correlation between electrophoretic mobility and applied electric field, electrokinetic responses could be rapidly monitored. Native membranes are less charged than white membrane preparations (from the R1...

journal_title：Biochemical and biophysical research communications

authors： Packer L,Arrio B,Johannin G,Volfin P

更新日期：1984-07-18 00:00:00

abstract：:Activation of the classical IκB kinases (IKKα and IKKβ) was previously shown to contribute to obesity-induced inflammation and insulin resistance. Using knockout mice, we investigated whether the related isoform IKKε plays a similar metabolic role. IKKε(-/-) mice had reduced body weight, leptin levels, as well as high...

journal_title：Biochemical and biophysical research communications

authors： Scheja L,Heese B,Seedorf K

更新日期：2011-04-08 00:00:00

abstract：:Several human and rodent tumor cell lines were examined for the presence of integrin mRNAs by dot- and Northern-blot analysis. All tumor cells tested expressed mRNAs for alpha 5, alpha IIb, beta 1 and beta 3. The mRNA of beta 2 integrin was not detectable and that of alpha V integrin was found only in certain cells. N...

journal_title：Biochemical and biophysical research communications

authors： Chang SY,Chen YQ,Fitzgerald LA,Honn KV

更新日期：1991-04-15 00:00:00

abstract：:CRAMP-18 (GEKLKKIGQKIKNFFQKL) is the antibacterial sequence derived from CRMAP, a member of cathelicidin-derived antimicrobial peptides. To develop the novel antibiotic peptides useful as therapeutic drugs requires strong antibiotic activity against bacterial and fungal cells without hemolytic effect. To this goal, th...

journal_title：Biochemical and biophysical research communications

authors： Shin SY,Kang SW,Lee DG,Eom SH,Song WK,Kim JI

更新日期：2000-09-07 00:00:00

abstract：:In mammals, behavioral and physiological processes display 24-h rhythms that are regulated by a circadian system. In the present study, we investigated the possibility that the expression of clock genes in peripheral leukocytes can be used to assess the circadian clock system. We found that Per1 and Per2 exhibit circa...

journal_title：Biochemical and biophysical research communications

authors： Fukuya H,Emoto N,Nonaka H,Yagita K,Okamura H,Yokoyama M

更新日期：2007-03-23 00:00:00

abstract：:We found that both RNA and cDNA preparations derived from melanocytes contain a RT-PCR inhibitor that copurified with nucleic acids. Investigation of the candidate inhibitor melanin revealed that it potently blocks PCR at concentrations below 200 ng/ml, whereas 100 microg/ml melanin was required to inhibit reverse tra...

journal_title：Biochemical and biophysical research communications

authors： Eckhart L,Bach J,Ban J,Tschachler E

更新日期：2000-05-19 00:00:00

abstract：:Dystroglycan has recently been characterized in blood tissue cells, as part of the dystrophin glycoprotein complex but to date nothing is known of its role in the differentiation process of neutrophils. We have investigated the role of dystroglycan in the human promyelocytic leukemic cell line HL-60 differentiated to ...

journal_title：Biochemical and biophysical research communications

authors： Martínez-Zárate AD,Martínez-Vieyra I,Alonso-Rangel L,Cisneros B,Winder SJ,Cerecedo D

更新日期：2014-06-06 00:00:00

abstract：:FENIB (familial encephalopathy with neuroserpin inclusion bodies) is caused by intracellular accumulation/polymerization of mutant neuroserpins in the endoplasmic reticulum (ER). Transgenic rats overexpressing megsin (Tg meg), a newly identified serine protease inhibitor (serpin), demonstrated intraneuronal periodic-a...

journal_title：Biochemical and biophysical research communications

authors： Takano K,Kitao Y,Inagi R,Momoi T,Matsuyama T,Miyata T,Yoneda Y,Iso H,Stern DM,Hori O,Ogawa S

更新日期：2006-08-04 00:00:00

abstract：:The bacterial toxin Shiga toxin (Stx) is transported retrogradely from early endosomes to the Golgi apparatus on its way to the endoplasmic reticulum (ER) and the cytosol. In this study we explored the functions of the two phosphoinositide binding proteins Sorting nexin 1 (SNX1) and Sorting nexin 2 (SNX2) in endosomal...

journal_title：Biochemical and biophysical research communications

authors： Utskarpen A,Slagsvold HH,Dyve AB,Skånland SS,Sandvig K

更新日期：2007-06-29 00:00:00

abstract：:In Saccharomyces cerevisiae, transcription of ARO9 and ARO10 genes, involved in the catabolism of aromatic amino acids, is activated by Aro80 transcription factor in response to aromatic amino acids. Here we show that the transcription of ARO9 and ARO10 is also induced by heat shock in an Aro80-dependent manner. Howev...

journal_title：Biochemical and biophysical research communications

authors： Lee K,Sung C,Kim BG,Hahn JS

更新日期：2013-08-16 00:00:00

abstract：:Complementary DNA corresponding to total poly(A)+-RNA from the human A431 epidermoid carcinoma cell line was cloned in the phage expression vector lambda gt 11. An epidermal growth factor (EGF) receptor cDNA clone was obtained by screening of the expression library with a rabbit polyclonal antibody (IgG), raised to th...

journal_title：Biochemical and biophysical research communications

authors： Simmen FA,Gope ML,Schulz TZ,Wright DA,Carpenter G,O'Malley BW

更新日期：1984-10-15 00:00:00

abstract：:The Andean potato weevil, Premnotrypes vorax, an insect of the order Coleoptera, is a major cause of damage to potato crops in the Andean regions of South America. The insecticidal Cry proteins from Bacillus thuringiensis are useful biological pesticides, and some are toxic to Coleopteran insects. We overexpressed rec...

journal_title：Biochemical and biophysical research communications

authors： Gomez S,Mateus AC,Hernandez J,Zimmermann BH

更新日期：2000-12-20 00:00:00

abstract：:The polyamines spermidine, spermine and putrescine, by themselves, at physiological concentrations, induce the transport of the precursor of ornithine carbamoyltransferase into isolated rat liver mitochondria. The presence of polyamines in the transport medium results in the approach of both mitochondrial membranes, s...

journal_title：Biochemical and biophysical research communications

authors： Marcote MJ,González-Bosch C,Miralles VJ,Hernández-Yago J,Grisolía S

更新日期：1989-01-16 00:00:00

abstract：:Recent studies have established that polypeptide growth factors cause an elevation of the cytoplasmic pH (pHi) in cultured mammalian cells by stimulating Na+/H+ exchange. We show that vanadate, previously found to act as a mitogen for a number of cells, reversibly activates Na+/H+ exchange at micromolar concentrations...

journal_title：Biochemical and biophysical research communications

authors： Cassel D,Zhuang YX,Glaser L

更新日期：1984-01-30 00:00:00

abstract：:Myocardial ischemia/reperfusion (I/R) still have high morbidity and mortality worldwide. Platelet activating factor (PAF) is a potent phospholipid regulator of inflammation. PAF acts on a single receptor (PAFR), which is expressed on cellular and nuclear membranes of various cell types. The study is aimed to explore i...

journal_title：Biochemical and biophysical research communications

authors： Wang EW,Han YY,Jia XS

更新日期：2018-01-22 00:00:00

abstract：:Osteoporosis is a common bone disorder with adverse effects on oral osseointegration, and the effects of metformin on bone metabolism have received increasing attention. The aim of the present study was to test the hypothesis that metformin promoted osteogenesis of bone mesenchymal stem cells (BMSCs) and osseointegrat...

journal_title：Biochemical and biophysical research communications

authors： Lin J,Xu R,Shen X,Jiang H,Du S

更新日期：2020-10-15 00:00:00

abstract：:Amyloid fibrils were isolated from amyloid-laden tissue obtained from a chronic hemodialysis patient with carpal tunnel syndrome. After solubilization in guanidine HCl, a significant amount of the protein was located in a homogeneous low molecular weight fraction. The protein was found to be identical to beta 2-microg...

journal_title：Biochemical and biophysical research communications

authors： Gejyo F,Yamada T,Odani S,Nakagawa Y,Arakawa M,Kunitomo T,Kataoka H,Suzuki M,Hirasawa Y,Shirahama T

更新日期：1985-06-28 00:00:00

abstract：:Insulin in rat adipose tissue acts to increase the phosphorylation about 2.5-fold of a low molecular weight protein in the cytosol designated phosphoprotein m. Isoproterenol had no effect on the phosphorylation of phosphoprotein m. Some of the properties of phosphoprotein m are: soluble in 1% trichloro acetic acid, he...

journal_title：Biochemical and biophysical research communications

authors： Ramakrishna S,Benjamin WB

更新日期：1983-12-28 00:00:00

abstract：:Osteoclasts together with osteoblasts play pivotal roles in bone remodeling. Aberrations in osteoclast differentiation and activity contribute to osteopenic disease. Osteoclasts differentiate from monocyte/macrophage progenitors, a process that is initiated by the interaction between receptor activator of NF-κB (RANK)...

journal_title：Biochemical and biophysical research communications

authors： Wisutsitthiwong C,Buranaruk C,Pudhom K,Palaga T

更新日期：2011-11-18 00:00:00

abstract：:Three immunoreactive prolactin proteins (24 Kd, 16 Kd, and 12 Kd) were identified in the rat brain using sodium dodecyl sulphate polyacrylamide gel electrophoresis, and western blot analyses. In male and female brains, the primary prolactin protein has a molecular weight of 24 Kd which is similar to that of pituitary ...

journal_title：Biochemical and biophysical research communications

authors： DeVito WJ

更新日期：1988-01-29 00:00:00

abstract：INTRODUCTION:SIRT2 is a NAD(+)-dependent deacetylases and associated with numerous processes such as infection, carcinogenesis, DNA damage and cell cycle regulation. However, the role of SIRT2 in inflammatory process in macrophage remains unclear. MATERIALS AND METHODS:In the present study, we have evaluated the regul...

journal_title：Biochemical and biophysical research communications

authors： Lee AS,Jung YJ,Kim D,Nguyen-Thanh T,Kang KP,Lee S,Park SK,Kim W

更新日期：2014-08-08 00:00:00

abstract：:Hypoxia is generally detected in central regions of solid tumors and regulates a variety of transcription factors including hypoxia-inducible factor-1 (HIF-1). HIF-1 plays a pivotal role in cellular response to low oxygen concentration, such as angiogenesis in tumor. Here, we found that a histone deacetylase (HDAC) in...

journal_title：Biochemical and biophysical research communications

authors： Mie Lee Y,Kim SH,Kim HS,Jin Son M,Nakajima H,Jeong Kwon H,Kim KW

更新日期：2003-01-03 00:00:00