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Analysis of integrin mRNA in human and rodent tumor cells.

Abstract：

:Several human and rodent tumor cell lines were examined for the presence of integrin mRNAs by dot- and Northern-blot analysis. All tumor cells tested expressed mRNAs for alpha 5, alpha IIb, beta 1 and beta 3. The mRNA of beta 2 integrin was not detectable and that of alpha V integrin was found only in certain cells. Northern blotting was carried out in three selected tumor cell lines: Clone A, HEL and B16a. An apparent difference in the mRNA species coding for the alpha IIb beta 3 integrin, but not for alpha 5 and beta 1, was found. Our result suggests that alternative splicing of integrin genes may be one of the important mechanisms in regulating alpha IIb beta 3 expression and function in different tumor cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chang SY,Chen YQ,Fitzgerald LA,Honn KV

doi

10.1016/0006-291x(91)90896-f

subject

Has Abstract

pub_date

1991-04-15 00:00:00

pages

108-13

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(91)90896-F

journal_volume

176

pub_type

杂志文章

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