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The human involucrin gene is transcriptionally repressed through a tissue-specific silencer element recognized by Oct-2.

Abstract：

:Involucrin is an important marker of epithelial differentiation which expression is upregulated just after basal cells are pushed into the suprabasal layer in stratified epithelia. Several transcription factors and regulatory elements had been described as responsible for turning on the gene. However, it is evident that in basal cell layer, additional mechanisms are involved in keeping the gene silent before the differentiation process starts. In this work, we located a potential transcriptional silencer in a 52bp sequence whose integrity is necessary for silencing the proximal enhancer promoter element (PEP) in multiplying keratinocytes. Octamer-binding sites were noticed in this fragment and the specific binding of Oct-2 transcription factor was detected. Oct-2 appears to be implicated in an epithelial-specific repression activity recorded only in keratinocytes and C33-A cell line. Overexpression of Oct-2 repressed the involucrin promoter activity in epithelial cells and in the presence of the silencer element.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Azuara-Liceaga E,Sandoval M,Corona M,Gariglio P,López-Bayghen E

doi

10.1016/j.bbrc.2004.04.034

subject

Has Abstract

pub_date

2004-05-28 00:00:00

pages

361-71

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X04007594

journal_volume

318

pub_type

杂志文章

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