当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Stachybotrydial, a potent inhibitor of fucosyltransferase and sialyltransferase.

Stachybotrydial, a potent inhibitor of fucosyltransferase and sialyltransferase.

Abstract：

:Elevated expression of fucosylated glycoconjugates and fucosyltransferases (Fuc-Ts) is found in various tumor cells and has been correlated with aspects of tumor progression such as cell adhesion and metastasis. Thus, fucosyltransferase inhibitors are potentially useful as anti-tumor agents. In the present study, three known spirocyclic drimanes (1, 2, and 3) were isolated from the culture broth of the fungus Stachybotrys cylindrospora. Compound 1 (stachybotrydial) exhibits potent inhibitory activity against alpha1,3-fucosyltransferase (Fuc-TV) during screening, while compounds 2 and 3 show no such inhibitory activity. Kinetic analysis indicates that compound 1 is an uncompetitive inhibitor with respect to GDP-fucose and a noncompetitive inhibitor with respect to N-acetyllactosamine with Ki values of 10.7 and 9.7 microM, respectively. In addition, all three compounds also possess inhibitory activity against sialyltransferase (ST) but not against beta1,4-galactosyltransferase. These observations provide novel chemical structure information that will help in the design of novel Fuc-T and ST inhibitors.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lin TW,Chang WW,Chen CC,Tsai YC

doi

10.1016/j.bbrc.2005.03.232

subject

Has Abstract

pub_date

2005-06-17 00:00:00

pages

953-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)00703-5

journal_volume

331

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Vitamin D fails to prevent serum starvation- or staurosporine-induced apoptosis in human and rat osteosarcoma-derived cell lines.

    abstract：:Previous studies have suggested that 1,25(OH)2D3, the active form of vitamin D3, may increase the survival of bone-forming osteoblasts through an inhibition of apoptosis. On the other hand, vitamin D3 has also been shown to trigger apoptosis in human cancer cells, including osteosarcoma-derived cell lines. In the pres...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.03.061

    authors： Witasp E,Gustafsson AC,Cotgreave I,Lind M,Fadeel B

    更新日期：2005-05-13 00:00:00

  • Regulation of hepatic stearoyl-CoA desaturase gene 1 by vitamin A.

    abstract：:The effect of vitamin A supplementation on stearoyl-CoA desaturase gene 1 expression in mouse liver was characterized. Normal BALB/c mice were fed 0.01% and 0.1% retinol palmitate as components of nonpurified diets. This treatment resulted in a 3-fold and a 7-fold induction of SCD1 mRNA levels, respectively, as determ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6070

    authors： Miller CW,Waters KM,Ntambi JM

    更新日期：1997-02-03 00:00:00

  • Interaction with Ppil3 leads to the cytoplasmic localization of Apoptin in tumor cells.

    abstract：:Apoptin, a small protein encoded by chicken anemia virus (CAV), induces cell death specifically in cancer cells. In normal cells, Apoptin remains in the cytoplasm; whereas in cancerous cells, it migrates into the nucleus and kills the cell. Cellular localization appears to be crucial. Through a yeast two-hybrid screen...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.04.178

    authors： Huo DH,Yi LN,Yang J

    更新日期：2008-07-18 00:00:00

  • AGR2 is a target of canonical Wnt/β-catenin signaling and is important for stemness maintenance in colorectal cancer stem cells.

    abstract：:Colorectal cancer is one of the leading causes of cancer-related deaths. Due to relapse after current therapy regimens, cancer stem cells (CSCs) are being studied to target this small tumor-initiating population. Anterior gradient 2 (AGR2), a disulfide isomerase protein, is a well-known pro-oncogenic/metastatic oncoge...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.05.154

    authors： Dahal Lamichane B,Jung SY,Yun J,Kang S,Kim DY,Lamichane S,Kim YJ,Park JH,Jang WB,Ji ST,Dehua L,Ha JS,Kim YH,Kwon SM

    更新日期：2019-08-06 00:00:00

  • Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells.

    abstract：:The process of endochondral ossification is strictly regulated by a variety of extracellular and intracellular factors. Recently, it has become recognized that specific miRNAs are involved in this process by regulating the expression of the relevant genes at the post-transcriptional level. In this present study we obt...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.10.016

    authors： Sumiyoshi K,Kubota S,Ohgawara T,Kawata K,Nishida T,Shimo T,Yamashiro T,Takigawa M

    更新日期：2010-11-12 00:00:00

  • Uromodulin (Tamm-Horsfall protein) is a leukocyte adhesion molecule.

    abstract：:Uromodulin (Tamm-Horsfall protein), the most abundant constituent of human urine, is synthesized exclusively in the kidney tubular epithelium and its amino acid sequence suggests a capacity for cell adhesion. We investigated adhesion between human uromodulin and neutrophils by allowing uromodulin, immobilized on micro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1445

    authors： Toma G,Bates JM Jr,Kumar S

    更新日期：1994-04-15 00:00:00

  • The inhibitory effect of ziprasidone on voltage-dependent K+ channels in coronary arterial smooth muscle cells.

    abstract：:We investigated the effect of ziprasidone, a widely used treatment for schizophrenia, on voltage-dependent K+ (Kv) channels of coronary arterial smooth muscle cells using the patch-clamp technique. Ziprasidone dose-dependently inhibited Kv channels with an IC50 value of 0.39 ± 0.06 μM and a Hill coefficient of 0.62 ± ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.06.038

    authors： An JR,Seo MS,Jung HS,Heo R,Kang M,Ha KS,Park H,Park WS

    更新日期：2020-08-20 00:00:00

  • Three-hybrid strategy reveals a peptide segment that specifically binds to the 3'-untranslated region of NF-IL6 mRNA.

    abstract：:The 3'UTR of eukaryotic mRNA is an important regulation region, on which many trans factors act. In recent years, a series of 3'UTRs were shown to have tumor suppressor function, including the 3'UTR of the human nuclear factor for interleukin-6 (NF-IL6 3'UTR). To understand molecular basis for this function, we have t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3425

    authors： He YZ,Liu DG

    更新日期：2000-09-16 00:00:00

  • NSAIDs acutely inhibit TRPC channels in freshly isolated rat glomeruli.

    abstract：:Using a novel approach for analysis of TRPC channel activity, we report here that NSAIDs are involved into regulation of TRPC channels in the podocytes of the freshly isolated decapsulated glomeruli. Fluorescence and electron microscopy techniques confirmed the integrity of podocytes in the glomeruli. Western blotting...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.04.005

    authors： Ilatovskaya DV,Levchenko V,Ryan RP,Cowley AW Jr,Staruschenko A

    更新日期：2011-05-06 00:00:00

  • HMGB1-containing nucleosome mediates chemotherapy-induced metastasis of human lung cancer.

    abstract：:While chemotherapy is an important and widely used therapeutic for cancer, it may facilitate cancer metastasis. Herein, we report that human lung cancer cells exert higher invasion and metastasis after chemotherapy. In a human lung cancer xenograft model, chemotherapy promotes the cancer invasion and metastasis in HMG...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.04.150

    authors： Wang K,Shan S,Wang S,Gu X,Zhou X,Ren T

    更新日期：2018-06-07 00:00:00

  • Identification of 'molten globule'-like state in all beta-sheet protein.

    abstract：:The cardiotoxin analogue III (CTX III), isolated from the Taiwan Cobra venom (Naja naja atra), is a sixty amino acid, all beta-sheet protein. The 2,2,2-trifluoro ethanol (TFE) induced unfolding of CTX III is studied under acidic conditions (pH 2.5). Using circular dichroism, 1-anilino-8-napthalene sulphonic acid bindi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1221

    authors： Kumar TK,Jayaraman G,Lee CS,Sivaraman T,Lin WY,Yu C

    更新日期：1995-02-15 00:00:00

  • Rimonabant is a dual inhibitor of acyl CoA:cholesterol acyltransferases 1 and 2.

    abstract：:Acyl coenzyme A:cholesterol acyltransferase (ACAT) catalyzes the intracellular synthesis of cholesteryl esters (CE). Both ACAT isoforms, ACAT1 and ACAT2, play key roles in the pathophysiology of atherosclerosis and ACAT inhibition retards atherosclerosis in animal models. Rimonabant, a type 1 cannabinoid receptor (CB1...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.06.134

    authors： Netherland C,Thewke DP

    更新日期：2010-08-06 00:00:00

  • Significance of glycosylation in Notch signaling.

    abstract：:Notch signaling is essential for cell-fate specification in metazoans, and dysregulation of the pathway leads to a variety of human diseases including heart and vascular defects as well as cancer. Glycosylation of the Notch extracellular domain has emerged as an elegant means for regulating Notch activity, especially ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2014.05.115

    authors： Takeuchi H,Haltiwanger RS

    更新日期：2014-10-17 00:00:00

  • Estrogen downregulates gp130 expression in HUVECs by regulating ADAM10 and ADAM17 via the estrogen receptor.

    abstract：:Glycoprotein130 (gp130) is an important signal transducer in the interleukin-6 (IL-6) trans-signaling pathway, which plays a crucial role in chronic inflammation in atherosclerosis. Studies suggest that estrogen can inhibit IL-6/gp130 signaling and reduce the risk of coronary artery disease, but the precise mechanism ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.01.008

    authors： Zhou M,Dai W,Cui Y,Li Y

    更新日期：2020-03-12 00:00:00

  • FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation.

    abstract：:Intricate cross-talks exist among multiple post-translational modifications that play critical roles in various cellular events, such as the control of gene expression and regulation of protein function. Here, the cross-talk between O-GlcNAcylation and ubiquitination was investigated in HEK293T cells. By PCR array, 84...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.07.091

    authors： Feng Z,Hui Y,Ling L,Xiaoyan L,Yuqiu W,Peng W,Lianwen Z

    更新日期：2013-08-23 00:00:00

  • Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding.

    abstract：:Lung metastasis is a primary obstacle in the clinical treatment of metastatic breast cancer. Most patients with lung metastasis eventually die of recurrence. Recurrence may be related to self-seeding, which occurs when circulating tumor cells re-seed into the tumors they originated from (metastasis or carcinoma in sit...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.06.009

    authors： Huang H,Zheng X,Cai C,Yao Z,Lu S,Meng X,Miao Y,He Z,Cai C,Zou F

    更新日期：2018-09-03 00:00:00

  • Single channel behavior of matrix porin of Escherichia coli.

    abstract：:Porins are trimeric proteins in the outer membranes of Gram-negative bacteria. Several of them, among them matrix porin of Escherichia coli, form symmetrically voltage-gated ion channels in planar bilayers. Trimers exhibit negative resistance at potentials larger than +/- 90mV. Here we show that, after two pores withi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1094

    authors： Buehler LK,Rosenbusch JP

    更新日期：1993-01-29 00:00:00

  • Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase.

    abstract：:Diaminopimelate (DAP) epimerase catalyzes the stereoinversion of ll-DAP to meso-DAP, a precursor of l-lysine and an essential component of the bacterial peptidoglycan. This function is vital to bacteria and the enzyme therefore represents an attractive target for the design of novel anti-bacterials. DAP epimerase belo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.09.012

    authors： Pillai B,Cherney M,Diaper CM,Sutherland A,Blanchard JS,Vederas JC,James MN

    更新日期：2007-11-23 00:00:00

  • Curative and protective effects of L-arginine on carbon tetrachloride-induced hepatotoxicity in mice.

    abstract：:L-arginine may aid in the liver detoxification and may benefit in the treatment of liver disorders such as liver injury. The present study was to investigate the possible protective and curative effects of L-arginine on carbon tetrachloride (CCl(4)) induced hepatotoxicity. Mice received a single dose of CCl(4). L-argi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.05.102

    authors： Saad EA

    更新日期：2012-06-22 00:00:00

  • Nucleophile specificity in chymotrypsin peptide synthesis.

    abstract：:The partitioning of the acylenzyme acetyl-(Gly)n-Phe(NO2)-chymotrypsin (n = 0,1,2) to peptide and peptide acid is observed spectrophotometrically. Values of partitioning ratios for various nucleophiles are calculated from the spectral data. They are a measure for the "true" nucleophile reactivity and are useful in the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91103-3

    authors： Petkov DD,Stoineva I

    更新日期：1984-01-13 00:00:00

  • MicroRNA involvement in glioblastoma pathogenesis.

    abstract：:MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2009.06.034

    authors： Novakova J,Slaby O,Vyzula R,Michalek J

    更新日期：2009-08-14 00:00:00

  • Transcriptional regulation of hexokinase II in denervated rat skeletal muscle.

    abstract：:Hexokinase II protein is augmented in denervated skeletal muscle; therefore, we determined if hexokinase II gene transcription rates and mRNA levels are increased with denervation. The right hindlimb skeletal muscles of male rats were denervated while the left hindlimbs were sham operated. Seventy-two h following surg...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7241

    authors： Jones JP,Roberts BR,Tapscott EB,Dohm GL

    更新日期：1997-09-08 00:00:00

  • Identification of two additional plasmodesmata localization domains in the tobacco mosaic virus cell-to-cell-movement protein.

    abstract：:Despite decades of intensive studies, the failure to identify plasmodesmata (PD) localization sequences has constrained our understanding of Tobacco mosaic virus (TMV) movement. Recently, we identified the first PD localization signal (major PLS) in the TMV movement protein (MP), which encompasses the first 50 amino a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.093

    authors： Liu Y,Huang C,Zeng J,Yu H,Li Y,Yuan C

    更新日期：2020-01-01 00:00:00

  • Tumor necrosis factor upregulates interleukin-4 receptors on murine sarcoma cells.

    abstract：:We have previously shown that murine solid tumor cells express high affinity IL-4 receptors (IL-4R) which are internalized after binding to ligand. In the present study, we have examined the regulation of IL-4R by TNF. We demonstrate that TNF upregulated the expression of IL-4R on murine MCA-106 sarcoma cells. Maximum...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2636

    authors： Puri RK,Leland P

    更新日期：1993-12-30 00:00:00

  • Clathrin-coated vesicles from human placenta contain GTP-binding proteins.

    abstract：:Biochemical and morphological techniques were used to investigate the GTP-binding proteins of clathrin-coated vesicles. Binding of [3H]GTP to clathrin coats was demonstrated by electron microscopic autoradiography. Purified coated vesicles bound 5.2 pmol [35S]GTP gamma S/mg protein. Addition of GTP or GTP gamma S, but...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)90505-2

    authors： Lenhard JM,Levy MA,Stahl PD

    更新日期：1991-01-15 00:00:00

  • Transcriptional regulation of gamma-glutamylcysteine synthetase-heavy subunit by oxidants in human alveolar epithelial cells.

    abstract：:We studied the regulation of glutathione (GSH) synthesis and characterised the 5'-promoter region of the gamma-glutamylcysteine synthetase-heavy subunit (gammaGCS-HS) gene in human alveolar type II cells (A549) following exposure to menadione (MQ) and hydrogen peroxide (H2O2). Both MQ (100 microM) and H2O2 (100 microM...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1888

    authors： Rahman I,Bel A,Mulier B,Lawson MF,Harrison DJ,Macnee W,Smith CA

    更新日期：1996-12-24 00:00:00

  • Magnetic characterization of Daphnia resting eggs.

    abstract：:This study characterized the magnetic materials found within Daphnia resting eggs by measuring static magnetization with a superconducting quantum interference device (SQUID) magnetometer, after forming two types of conditions, each of which consists of zero-field cooling (ZFC) and field cooling (FC). Magnetic ions, s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.10.078

    authors： Sakata M,Kawasaki T,Shibue T,Takada A,Yoshimura H,Namiki H

    更新日期：2006-12-15 00:00:00

  • Tyrosine phosphorylation of vinculin at position 1065 modifies focal adhesion dynamics and cell tractions.

    abstract：:Focal adhesions (FAs) connect the cellular actin cytoskeleton via integrin with the extracellular matrix. They comprise of many structural and signaling proteins which are highly dynamic, well regulated, and responsible for the sensing of physical properties from the environment. Vinculin is a protein that incorporate...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.07.110

    authors： Küpper K,Lang N,Möhl C,Kirchgessner N,Born S,Goldmann WH,Merkel R,Hoffmann B

    更新日期：2010-09-03 00:00:00

  • Thiazolidinediones inhibit REG Ialpha gene transcription in gastrointestinal cancer cells.

    abstract：:REG (Regenerating gene) Ialpha protein functions as a growth factor for gastrointestinal cancer cells, and its mRNA expression is strongly associated with a poor prognosis in gastrointestinal cancer patients. We here demonstrated that PPARgamma-agonist thiazolidinediones (TZDs) inhibited cell proliferation and REG Ial...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.12.113

    authors： Yamauchi A,Takahashi I,Takasawa S,Nata K,Noguchi N,Ikeda T,Yoshikawa T,Shervani NJ,Suzuki I,Uruno A,Unno M,Okamoto H,Sugawara A

    更新日期：2009-02-13 00:00:00

  • Conformational dynamics of loops L11 and L12 of kinesin as revealed by spin-labeling EPR.

    abstract：:The EPR spectra of the spin labels attached to loops L11 and L12 of kinesin were resolved into slow (rotational correlation time, tau=10-45 ns) and fast (tau=2 ns) components. The fraction of the slow component increased considerably when kinesin was complexed with a microtubule (MT). On MT binding and in the presence...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.10.043

    authors： Yamada MD,Maruta S,Yasuda S,Kondo K,Maeda H,Arata T

    更新日期：2007-12-21 00:00:00