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HMGB1-containing nucleosome mediates chemotherapy-induced metastasis of human lung cancer.

Abstract：

:While chemotherapy is an important and widely used therapeutic for cancer, it may facilitate cancer metastasis. Herein, we report that human lung cancer cells exert higher invasion and metastasis after chemotherapy. In a human lung cancer xenograft model, chemotherapy promotes the cancer invasion and metastasis in HMGB1-dependent manner. Further studies identify HMGB1-containing nucleosome from chemotherapy-induced apoptotic cancer cells as an effective factor. Such nucleosome functions through TLR4 and TLR9 to drive cancer invasion and metastasis. In lung cancer patients, circulating HMGB1-containing nucleosome is higher in those under chemotherapy, predicting poorly cancer cell differentiation state, enhanced cancer invasion and advanced TNM stages. These findings provide a novel mechanism by which the tumor metastasis is propagated in lung cancer patients, especially in those under chemotherapy, and a clue for developing therapeutic strategies against chemotherapy-induced metastasis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wang K,Shan S,Wang S,Gu X,Zhou X,Ren T

doi

10.1016/j.bbrc.2018.04.150

subject

Has Abstract

pub_date

2018-06-07 00:00:00

pages

758-764

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)30931-8

journal_volume

500

pub_type

杂志文章

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