Growth inhibition of leukemia cell line CEM-C1 by farnesol: effects of phosphatidylcholine and diacylglycerol.

Abstract:

:Acute leukemia cells of the established line CEM-C1 were treated during growth in serum-free medium with various concentrations of trans-trans farnesol. At concentrations ranging from 9.0 to 31.5 microM, farnesol inhibited growth of these cells without causing cell lysis. This effect was preceded by very rapid inhibition of choline incorporation in cellular lipid fraction. The growth inhibitory effect was prevented to a large extent by incubation with phosphatidylcholine or diacylglycerol.

authors

Melnykovych G,Haug JS,Goldner CM

doi

10.1016/s0006-291x(05)80842-3

subject

Has Abstract

pub_date

1992-07-15 00:00:00

pages

543-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)80842-3

journal_volume

186

pub_type

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