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Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase.

Abstract：

:A human cell line established from a patient of an acute monocytic leukemia (THP-1) retained an ability to synthesize and secrete plasma apolipoprotein E like protein. The protein was identified with monospecific antibody raised against human plasma apolipoprotein E. The cells also secreted lipoprotein lipase (EC 3.1.1.34). The enzyme was characterized as lipoprotein lipase on the basis of the requirement of apolipoprotein C-II as an activator and the inhibition of its activity by sodium chloride. The secretion of both apolipoprotein E and lipoprotein lipase was markedly enhanced in the process of differentiation into macrophage-like cells by the addition of 4 beta-phorbol 12 beta-myristate 13 alpha-acetate.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tajima S,Hayashi R,Tsuchiya S,Miyake Y,Yamamoto A

doi

10.1016/0006-291x(85)90637-0

subject

Has Abstract

pub_date

1985-01-16 00:00:00

pages

526-31

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)90637-0

journal_volume

126

pub_type

杂志文章

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