当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > A CRE and the region occupied by a protein induced by growth factors contribute to up-regulation of cyclin D1 expression in hepatocytes.

A CRE and the region occupied by a protein induced by growth factors contribute to up-regulation of cyclin D1 expression in hepatocytes.

Abstract：

:Induction of cyclin D1 expression is a critical feature of growth factor-induced cell proliferation in hepatocytes. To clarify the mechanisms regulating cyclin D1 gene expression, we isolated the rat cyclin D1 gene and analyzed the transcriptional regulatory elements in rat hepatoma cells and primary cultured rat hepatocytes. Two transcriptional regulatory regions were analyzed. One was mapped to a cAMP-responsive element (CRE) at position -41bp and was occupied by a CRE-binding protein (CREB), resulting in cyclin D1 expression. Another (CD1E0.7), located at -753bp, revealed high homology with binding sites for the Ets family, the hepatocyte nuclear factor-3beta, or the nuclear factor of activated T cells. However, CD1E0.7 did not interact with these nuclear factors and specific interaction with a protein extracted from growth factor-treated rat hepatocytes in primary cultures. These results indicate that CREB binds to the CRE and mediates activation of the cyclin D1 promoter, and suggest that CD1E0.7 may be possibly occupied by a protein induced by growth factors in hepatocytes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Moriuchi A,Ido A,Nagata Y,Nagata K,Uto H,Hasuike S,Hori T,Hirono S,Hayashi K,Tsubouchi H

doi

10.1016/s0006-291x(02)02867-x

subject

Has Abstract

pub_date

2003-01-10 00:00:00

pages

415-21

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X0202867X

journal_volume

300

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Partial characterization of guinea pig cholinephosphotransferase cDNA.

    abstract：:An alternative molecular biology strategy is needed to characterize cholinephosphotransferase (CPT) gene because of the complexity of the problem associated with the solubilization of the membrane-bound enzyme without denaturation. We have synthesized five heterologous oligonucleotide probes based on the published yea...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7862

    authors： Das SK,Beg O,Mukherjee S

    更新日期：1997-12-18 00:00:00

  • Sakuranetin induces adipogenesis of 3T3-L1 cells through enhanced expression of PPARgamma2.

    abstract：:Sakuranetin (5,4'-dihydroxy-7-methoxyflavone) belongs to the flavanone class of polyphenols predominantly known as phytoalexin in rice plant. In this study, we demonstrate that sakuranetin strongly induces differentiation of 3T3-L1 preadipocytes, as evidenced by increased triglyceride accumulation and glycerol-3-phosp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.146

    authors： Saito T,Abe D,Sekiya K

    更新日期：2008-08-08 00:00:00

  • Lipid rafts are involved in SARS-CoV entry into Vero E6 cells.

    abstract：:Lipid rafts often serve as an entry site for certain viruses. Here, we report that lipid rafts in Vero E6 cells are involved in the entry of severe acute respiratory syndrome coronavirus (SARS-CoV). Infectivity assay showed the integrity of lipid rafts was required for productive infection of pseudotyped SARS-CoV. Dep...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.02.023

    authors： Lu Y,Liu DX,Tam JP

    更新日期：2008-05-02 00:00:00

  • Effects of pre-incubation with C-type natriuretic peptide on nuclear maturation, mitochondrial behavior, and developmental competence of sheep oocytes.

    abstract：:In vitro produced mammalian embryos suffer from developmental failure, with a large proportion showing embryonic retardation, degradation, or apoptosis. This failure is due, in part, to incomplete oocyte cytoplasmic maturation. C-type natriuretic peptide (CNP) has been reported to act as a meiotic inhibitor. Here we e...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.02.054

    authors： Zhang T,Fan X,Li R,Zhang C,Zhang J

    更新日期：2018-02-26 00:00:00

  • The l-isoform but not d-isoforms of a JNK inhibitory peptide protects pancreatic beta-cells.

    abstract：:The activation of c-jun N-terminal kinase (JNK) in pancreatic islets is associated with impaired function and viability, and JNK inhibitory peptides (JNKIs) are cytoprotective. In particular, l-isoforms of JNKIs were shown to improve islets viability, while the d-retroinverso isoform of JNKI (RI-JNKI), with a higher t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.186

    authors： Fornoni A,Cobianchi L,Sanabria NY,Pileggi A,Molano RD,Ichii H,Rosero S,Inverardi L,Ricordi C,Pastori RL

    更新日期：2007-03-02 00:00:00

  • Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene.

    abstract：:This is the first systematic study on the pancreatic beta cell function in the heterozygous mouse with targeted disruption of the beta cell glucokinase gene. The heterozygotes' beta cell displayed the following characteristics: (1) impaired glucose sensitivity with normal glucose responsiveness, (2) poor discriminatio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1826

    authors： Aizawa T,Asanuma N,Terauchi Y,Suzuki N,Komatsu M,Itoh N,Nakabayashi T,Hidaka H,Ohnota H,Yamauchi K,Yasuda K,Yazaki Y,Kadowaki T,Hashizume K

    更新日期：1996-12-13 00:00:00

  • Salt-inducible kinase 2 regulates TFEB and is required for autophagic flux in adipocytes.

    abstract：:Dysregulation of autophagy has been observed in obesity and type 2 diabetes. Salt-inducible kinase 2 (SIK2), a member of the AMPK-related kinase family, is downregulated in adipocytes from obese or insulin resistant individuals and was previously demonstrated to regulate autophagy in cancer and normal cell lines. The ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.11.177

    authors： Negoita F,Säll J,Morén B,Stenkula K,Göransson O

    更新日期：2019-01-15 00:00:00

  • Expression in T-cells of the proapoptotic protein p66SHC is controlled by promoter demethylation.

    abstract：:p66Shc plays a key role in oxidative stress-induced apoptosis. p66Shc gene expression is tissue-specific and controlled by promoter methylation. In T-cells p66Shc expression is induced by a variety of apoptotic stimuli. We have addressed the mechanisms regulating p66Shc expression in T-cells. We show that the increase...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.08.039

    authors： Pezzicoli A,Ulivieri C,Capitani N,Ventura A,Pelicci P,Baldari CT

    更新日期：2006-10-13 00:00:00

  • Biological selectivity and functional aspects of protein tyrosine nitration.

    abstract：:The formation of nitric oxide in biological systems has led to the discovery of a number of post-translational protein modifications that could regulate protein function or potentially be utilized as transducers of nitric oxide signaling. Principal among the nitric oxide-mediated protein modifications are: the nitric ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-291x(03)00814-3

    authors： Ischiropoulos H

    更新日期：2003-06-06 00:00:00

  • ESR spin trapping investigation on peroxynitrite decomposition: no evidence for hydroxyl radical production.

    abstract：:The decomposition of peroxynitrite in the presence of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) generated 5,5-dimethylpyrrolidone-(2)-oxy-(1) (DMPOX) without formation of DMPO/OH. Formate enhanced the peroxynitrite decomposition but did not generate any detectable amount of formate-derived free radicals. Glutathione, cy...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2357

    authors： Shi X,Lenhart A,Mao Y

    更新日期：1994-09-30 00:00:00

  • Ferric nitrilotriacetate (Fe-NTA) is a potent hepatic tumor promoter and acts through the generation of oxidative stress.

    abstract：:Fe-NTA is a known renal carcinogen. However, little is known about its carcinogenic potential in liver. In this study we for the first time show that Fe-NTA is a potent hepatic tumor promoter. Fe-NTA administration induced dose dependently the hepatic ornithine decarboxylase (ODC) activity several folds as compared to...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2006

    authors： Iqbal M,Giri U,Athar M

    更新日期：1995-07-17 00:00:00

  • Atorvastatin induces tissue transglutaminase in human endothelial cells.

    abstract：:Tissue transglutaminase (tTgase) contributes to the organisation of the basement membrane and is therefore thought to be important for the integrity and stability of the vessel wall. In the present study, we hypothesised that the HMG-CoA reductase inhibitor atorvastatin may up-regulate the tTgase expression in endothe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.07.087

    authors： Soehnlein O,Eskafi S,Schmeisser A,Kloos H,Daniel WG,Garlichs CD

    更新日期：2004-09-10 00:00:00

  • Interaction of soluble CD4 with the chemokine receptor CCR5.

    abstract：:The chemokine receptor CCR5 is constitutively associated with the T cell co-receptor CD4 in plasma cell membranes. The CD4-CCR5 complex exhibits distinct binding properties for macrophage inflammatory protein 1beta (MIP-1beta) and enhanced G-protein signaling as compared with those of CCR5 alone. Here we report that r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01315-9

    authors： Wang X,Staudinger R

    更新日期：2003-08-08 00:00:00

  • Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells.

    abstract：:T315I mutation found in chronic myelogenous leukemia (CML) and Ph + ALL patients is the most serious one among resistance against BCR/ABL kinase inhibitors including imatinib and is only responsive to ponatinib (PNT). However, the novel strategy is required to reduce life-threatening adverse effects of PNT including i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.02.165

    authors： Inoue C,Sobue S,Kawamoto Y,Nishizawa Y,Ichihara M,Abe A,Hayakawa F,Suzuki M,Nozawa Y,Murate T

    更新日期：2020-05-14 00:00:00

  • Glioma inhibition by HGF/NK2, an antagonist of scatter factor/hepatocyte growth factor.

    abstract：:Strategies that antagonize growth factor signaling are attractive candidates for the biological therapy of brain tumors. HGF/NK2 is a secreted truncated splicing variant and potential antagonist of scatter factor/hepatocyte growth factor (SF/HGF), a multifunctional cytokine involved in the malignant progression of sol...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2935

    authors： Guerin C,Luddy C,Abounader R,Lal B,Laterra J

    更新日期：2000-06-24 00:00:00

  • Changes in tissue concentration of prostaglandins during endochondral bone differentiation.

    abstract：:Prostaglandins are known to be involved in bone metabolism as evidenced by the ability of PGE2 to induce bone resorption. It was, therefore, of interest to determine if there was an association of specific prostaglandin metabolites with the various stages of developing bone by utilizing the matrix-induced endochondral...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91660-1

    authors： Wientroub S,Wahl LM,Feuerstein N,Winter CC,Reddi AH

    更新日期：1983-12-28 00:00:00

  • Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells.

    abstract：:Apoptosis and autophagy are crucial mechanisms regulating cell death, and the relationship between apoptosis and autophagy in the liver has yet to be thoroughly explored. TIGAR (TP53-induced glycolysis and apoptosis regulator), which is a p53-inducible gene, functions in the suppression of ROS (reactive oxygen species...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.06.072

    authors： Ye L,Zhao X,Lu J,Qian G,Zheng JC,Ge S

    更新日期：2013-07-26 00:00:00

  • COBRA1 inhibits AP-1 transcriptional activity in transfected cells.

    abstract：:Mutations in the breast cancer susceptibility gene (BRCA1) account for a significant proportion of hereditary breast and ovarian cancers. Cofactor of BRCA1 (COBRA1) was isolated as a BRCA1-interacting protein and exhibited a similar chromatin reorganizing activity to that of BRCA1. However, the biological role of COBR...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.10.079

    authors： Zhong H,Zhu J,Zhang H,Ding L,Sun Y,Huang C,Ye Q

    更新日期：2004-12-10 00:00:00

  • Fat depot-specific differences in pref-1 gene expression and adipocyte cellularity between Wagyu and Holstein cattle.

    abstract：:Preadipocyte factor-1 (pref-1) is specifically expressed in preadipocytes and acts as a gatekeeper of adipogenesis by maintaining the preadipocyte state and preventing adipocyte differentiation. We hypothesized that the breed differences of adipogenic capacity in cattle could be explained by the expression level of pr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.01.177

    authors： Yamada T,Higuchi M,Nakanishi N

    更新日期：2014-03-07 00:00:00

  • The cytoplasmic domain of C-CAM1 tumor suppressor is necessary and sufficient for suppressing the tumorigenicity of prostate cancer cells.

    abstract：:We have previously shown that C-CAM1 cell adhesion molecule can suppress the growth of prostate cancer cells in vivo. In this study, we determined the minimal domain of C-CAM1 that is required for its tumor-suppressive activity. DU145 prostate cancer cells were infected with recombinant adenoviruses containing various...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1443

    authors： Estrera VT,Luo W,Phan D,Earley K,Hixson DC,Lin SH

    更新日期：1999-10-05 00:00:00

  • Inhibition by TRPA1 agonists of compound action potentials in the frog sciatic nerve.

    abstract：:Although TRPV1 and TRPM8 agonists (vanilloid capsaicin and menthol, respectively) at high concentrations inhibit action potential conduction, it remains to be unknown whether TRPA1 agonists have a similar action. The present study examined the actions of TRPA1 agonists, cinnamaldehyde (CA) and allyl isothiocyanate (AI...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.02.127

    authors： Matsushita A,Ohtsubo S,Fujita T,Kumamoto E

    更新日期：2013-04-26 00:00:00

  • Transforming growth factor alpha stimulates prostacyclin production by cultured human vascular endothelial cells more potently than epidermal growth factor.

    abstract：:Transforming growth factor alpha (TGF alpha) induces dose- and time-dependent stimulation of prostacyclin (PGI2) production by cultured human umbilical vein endothelial cells. The lowest stimulatory concentration of TGF alpha was 0.1 ng/ml and the maximal response, a 2.7-fold rise, was obtained with 10 ng/ml. The stim...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(89)80116-0

    authors： Ristimäki A

    更新日期：1989-05-15 00:00:00

  • Analysis of an intronic promoter within Synj2.

    abstract：:Synj2 (synaptojanin 2) encodes an inositol polyphosphate phosphatase that functions in recycling neurotransmitter vesicles and is implicated in spermatogenesis. Transcription of Synj2 is thought to occur from one of two promoters based on analysis of a variable 5' untranslated region. Clustering all known mouse Synj2 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.09.115

    authors： Planchart A

    更新日期：2013-11-01 00:00:00

  • Study on AAV-mediated gene therapy for diabetes in humanized liver mouse to predict efficacy in humans.

    abstract：:Most in vivo studies on the conversion to insulin-producing cells with AAV carrying PDX1 gene are performed in rodents. However, there is little information regarding Adeno-associated virus (AAV) carrying PDX1 gene transduced to human liver in vivo because accidental death caused by unpredicted factors cannot be denie...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.08.104

    authors： Hashimoto H,Mizushima T,Ogura T,Kagawa T,Tomiyama K,Takahashi R,Yagoto M,Kawai K,Chijiwa T,Nakamura M,Suemizu H

    更新日期：2016-09-23 00:00:00

  • Antigen-specific CD8+ T cells induced by the ubiquitin fusion degradation pathway.

    abstract：:We have developed a DNA vaccine encoding a fusion protein of ubiquitin (Ub) and target proteins at the N-terminus for effective induction of antigen-specific CD8(+) T cells. A series of expression plasmids encoding a model antigen, ovalbumin (OVA), fused with mutated Ub, was constructed. Western blotting analyses usin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.11.034

    authors： Imai T,Duan X,Hisaeda H,Himeno K

    更新日期：2008-01-25 00:00:00

  • Residue Glu83 plays a major role in negatively regulating alpha-synuclein amyloid formation.

    abstract：:Alpha-synuclein (alpha-syn) amyloid filaments are the major ultrastructural component of pathological inclusions that define several neurodegenerative disorders, including Parkinson disease and other disorders that are collectively termed synucleinopathies. Since the aggregation of alpha-syn is associated with the eti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.12.079

    authors： Waxman EA,Emmer KL,Giasson BI

    更新日期：2010-01-15 00:00:00

  • Isolation of laminin from human placental basement membranes: amnion, chorion and chorionic microvessels.

    abstract：:Laminin components were solubilized from basement membranes of amnion, chorion and chorionic microvessels of human placenta without prior protease digestion. These structures, after isolation, were initially processed in a sonicator bath containing a solution of Triton X-100, EDTA and 2M NaCl and the laminins extracte...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91730-8

    authors： Ohno M,Martinez-Hernandez A,Ohno N,Kefalides NA

    更新日期：1983-05-16 00:00:00

  • ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor.

    abstract：:p105 plays dual roles in NF-kappaB signaling: in its precursor form it inhibits NF-kappaB activation, but limited processing by the ubiquitin system generates the p50 active subunit of the transcription factor. Here we show that ABIN-1, an A20-binding protein that is also known to attenuate NF-kappaB activation, inhib...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.08.074

    authors： Cohen S,Ciechanover A,Kravtsova-Ivantsiv Y,Lapid D,Lahav-Baratz S

    更新日期：2009-11-13 00:00:00

  • Generation of insulin-secreting cells from adult rat pancreatic ductal epithelial cells induced by hepatocyte growth factor and betacellulin-delta4.

    abstract：:The present study was conducted to identify effective factors that could induce differentiation of pancreatic ductal epithelial cells (PDECs) into insulin-producing cells. We examined the effect of hepatocyte growth factor (HGF) and betacellulin-delta4 (BTC-delta4) on PDECs. We isolated PDECs from adult rats and stimu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.03.029

    authors： Zhan XR,Li XY,Liu XM,Zhou JH,Yang YL,Yi R,Zhang J,Yang BF

    更新日期：2009-05-01 00:00:00

  • Regulation of the solubilized bovine cerebral cortex muscarinic receptor by GTP and Na+.

    abstract：:The muscarinic acetylcholine receptor was solubilized, in a sensitive form for GTP and Na+, from bovine cerebral cortex using a zwitterionic detergent 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate. The solubilized muscarinic receptor displayed characteristics as follows: (1) high affinity to nanomolar co...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91709-6

    authors： Kuno T,Shirakawa O,Tanaka C

    更新日期：1983-05-16 00:00:00