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Melanosome degradation in epidermal keratinocytes related to lysosomal protease cathepsin V.

Abstract：

:The cause of hyperpigmentation, such as solar lentigo and seborrheic keratosis, is the excessive accumulation of melanin pigments in the epidermal basal layer. Melanin pigments are synthesized in the melanosomes, which are specific organelles produced by melanocytes in the basal layer. Melanosomes containing melanin pigments are transported to the neighboring keratinocytes. However, the behavior of melanosomes after being transported to the keratinocytes has been poorly understood. In this study, we focused on a lysosomal protease cathepsin V (CTSV) to clarify the mechanism underlying melanosome degradation in the keratinocytes. Using immunohistochemical observation, we found that CTSV was highly expressed across the entire epidermis in normal skin; however, CTSV expression levels were lower in the basal layer than those in the stratum corneum side in the hyperpigmented region. Moreover, we found that melanosome degradation was suppressed in CTSV knockdown cells. These results indicated that CTSV is involved in melanosome degradation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Homma T,Kageyama S,Nishikawa A,Nagata K

doi

10.1016/j.bbrc.2018.04.070

subject

Has Abstract

pub_date

2018-06-02 00:00:00

pages

339-343

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)30839-8

journal_volume

500

pub_type

杂志文章

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