Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells.

abstract：:The secondary structures of and the interactions between the intracellular domains (the three loops and the C-terminal tail) of the mouse-derived prostaglandin E2 receptor EP3beta subtype were investigated using peptides mimicking the domains. The N-termini of the peptides were palmitoylated to anchor on unilamellar v...

journal_title：Biochemical and biophysical research communications

authors： Yano Y,Shimbo T,Sugimoto Y,Matsuzaki K

更新日期：2008-07-11 00:00:00

abstract：:Recently, we have reported three monoclonal antibodies (mAbs) against purified human placental insulin-like growth factor (IGF)-I receptors. These antibodies, in contrast to the well-studied mAb alpha IR-3, stimulate binding of IGF-I and IGF-II to the receptor and DNA synthesis as well [Xiong, et al., Proc. Natl. Acad...

journal_title：Biochemical and biophysical research communications

authors： Li SL,Kato J,Paz IB,Kasuya J,Fujita-Yamaguchi Y

更新日期：1993-10-15 00:00:00

abstract：:The matrix metalloproteinases (MMPs) are a group of enzymes which have the ability to degrade extracellular matrix. They also cleave non-matrix proteins such as myelin basic protein and alpha 1-antitrypsin and they are able to process tumour necrosis factor-alpha (TNF) to its mature form. We have cloned, expressed and...

journal_title：Biochemical and biophysical research communications

authors： Chandler S,Cossins J,Lury J,Wells G

更新日期：1996-11-12 00:00:00

abstract：:We have isolated and sequenced a cDNA encoding the human luteinizing hormone--choriogonadotropin (LH/hCG) receptor. The deduced amino acid sequence (699 residues) containing seven putative transmembrane segments displays sequence similarity to G protein-coupled receptors. The receptor consists of 335 residue extracell...

journal_title：Biochemical and biophysical research communications

authors： Minegishi T,Nakamura K,Takakura Y,Miyamoto K,Hasegawa Y,Ibuki Y,Igarashi M,Minegish T corrected to Minegishi T

更新日期：1990-11-15 00:00:00

abstract：:Under many physiological circumstances, Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high-affinity choline uptake (HACU) in cholinergic neurons is thought to be rate-limiting in the biosynthesis of acetylcholine (ACh). Based on sequence information provided by the Human Genome Project and the recently...

journal_title：Biochemical and biophysical research communications

authors： Apparsundaram S,Ferguson SM,George AL Jr,Blakely RD

更新日期：2000-10-05 00:00:00

abstract：:Uracil-DNA glycosylase (UNG) is the primary enzyme responsible for removing uracil residues from DNA. Increasing evidence suggests that UNG may be a potential target for the development of novel antiviral and/or anticancer agents. To determine whether the uracil-DNA glycosylase inhibitor protein (UGI) could be used to...

journal_title：Biochemical and biophysical research communications

authors： Studebaker AW,Ariza ME,Williams MV

更新日期：2005-08-26 00:00:00

abstract：:ATF5 is a member of the CREB/ATF family of transcription factors. In the current study, using a transient transfection system to express FLAG epitope fusion proteins of ATF5, we have shown that CdCl(2) or NaAsO(3) increases the protein levels of ATF5 in cells, and that cadmium stabilizes the ATF5 protein. Proteasome i...

journal_title：Biochemical and biophysical research communications

authors： Uekusa H,Namimatsu M,Hiwatashi Y,Akimoto T,Nishida T,Takahashi S,Takahashi Y

更新日期：2009-03-13 00:00:00

abstract：:Mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene, are the major cause of X-linked retinitis pigmentosa (RP), in which exon open reading frame 15 (ORF15) of RPGR has been implicated to play a substantial role. We identified a novel hemizygous missense mutation E585K of RPGR from whole-exome sequencing...

journal_title：Biochemical and biophysical research communications

authors： Liu YS,Pan JQ,Wan JF,Ren CY,Xu ZH,Pan XB,Gao RN,Liu SQ,Zhang JL,Yao QH,Wang JH,Li EM,Rao JH,Hou P,Chen JH

更新日期：2020-10-15 00:00:00

abstract：:Recombination in a bovine papillomavirus shuttle vector carrying direct repeats of Moloney murine leukemia virus LTR sequence was examined. Differently from similar vectors carrying direct repeats of SV40 polyA addition signal or neomycin resistance gene, the vector exhibited no homologous recombination between the re...

journal_title：Biochemical and biophysical research communications

authors： Kitamura Y,Naito A,Yoshikura H

更新日期：1991-08-30 00:00:00

abstract：:Four conserved residues of Clostridium thermocellum endoglucanase CelC were replaced by site-directed mutagenesis. Proteins mutated in His-90, Asn-139 and Glu-140 showed strongly reduced activity, in agreement with predictions of sequence alignments. Mutations in Glu-140 did not result in any detectable change in Km, ...

journal_title：Biochemical and biophysical research communications

authors： Navas J,Béguin P

更新日期：1992-12-15 00:00:00

abstract：:We have isolated calpromotin, a protein reported abundant in human red cells and shown to be of significance for KCl transport. We show that calpromotin is identical to a radical scavenger protein, thiol-specific antioxidant protein (TSA). Calpromotin is known to exist partially as a large complex of identical subunit...

journal_title：Biochemical and biophysical research communications

authors： Kristensen P,Rasmussen DE,Kristensen BI

更新日期：1999-08-19 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) have been demonstrated to be intensively involved in the development of various carcinomas, including glioblastoma multiforme (GBM). However, only a few of them have been well characterized. LncRNA CASP5 have been found to be up-regulated in GBM tissues compared with normal tis...

journal_title：Biochemical and biophysical research communications

authors： Zhou Y,Dai W,Wang H,Pan H,Wang Q

更新日期：2018-06-12 00:00:00

abstract：:Here we integrate multiple Gaussian-functions analysis into fluorescence resonance energy transfer (FRET) two-hybrid assays (Gaussian FRET two-hybrid assay) to determine the stoichiometric ratios of intracellular hetero-oligomers in single living cells. This method adopts in multiple Gaussian-functions to fit the E-co...

journal_title：Biochemical and biophysical research communications

authors： Qu W,Du M,Yang F,Mai Z,Zhang C,Lin F,Ma Y,Chen T

更新日期：2019-05-07 00:00:00

abstract：:Wheat germ derivatives have been shown to inhibit inflammation-related diseases. In this study, a small peptide (YDWPGGRN) isolated from wheat germ was used to study its anti-inflammatory activity and its application in skin wound healing. Both the in vitro and in vivo results clearly showed that YDWPGGRN significantl...

journal_title：Biochemical and biophysical research communications

authors： Sui H,Wang F,Weng Z,Song H,Fang Y,Tang X,Shen X

更新日期：2020-04-16 00:00:00

abstract：:Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion of chondrogenesis of MSCs. During the processes of chondrogenic differentiation of MSCs, UCA1, miRN...

journal_title：Biochemical and biophysical research communications

authors： Shu T,He L,Wang X,Pang M,Yang B,Feng F,Wu Z,Liu C,Zhang S,Liu B,Wang Q,Rong L

更新日期：2019-06-18 00:00:00

abstract：:O2-dependent reactions of the ferric and ferrous forms of alpha-hydroxyheme complexed with water-soluble rat heme oxygenase-1 were examined by rapid-scan stopped-flow measurements. Ferric alpha-hydroxyheme reacted with O2 to form ferric verdoheme with an O2-dependent rate constant of 4x10(5) M(-1) s(-1) at pH 7.4 and ...

journal_title：Biochemical and biophysical research communications

authors： Sakamoto H,Takahashi K,Higashimoto Y,Harada S,Palmer G,Noguchi M

更新日期：2005-12-09 00:00:00

abstract：:The dodecapeptide MCLV3 is a functional peptide, derived from the CLV3 precursor protein, which is a candidate ligand of the CLV1/CLV2 receptor complex that restricts the stem cell population in the shoot apical meristem (SAM). MCLV3 can induce shoot and root meristem consumption, the typical phenotype of transgenic p...

journal_title：Biochemical and biophysical research communications

authors： Kondo T,Nakamura T,Yokomine K,Sakagami Y

更新日期：2008-12-05 00:00:00

abstract：:Vascular endothelial cell (VEC) apoptosis takes part in the development of various cardiovascular diseases. Heat shock protein 90 (HSP90) regulates apoptosis through various apoptosis associated client proteins. In previous study, we identified a novel HSP90 inhibitor HCP1 induced apoptosis in A549 human lung cancer c...

journal_title：Biochemical and biophysical research communications

authors： Wei Q,Zhang J,Su L,Zhao X,Zhao B,Miao J,Lin Z

更新日期：2019-03-26 00:00:00

abstract：:The involvement of Na+ in insulin-secretory responses to metabolizable and nonmetabolizable amino acids known to be cotransported with Na+, were examined using islet-derived BRIN-BD11 cells. At stimulatory (16.7 mM) glucose, 10 mM of l-alanine, alpha-aminoisobutyric acid (AIB) or l-proline stimulated 1.3- to 10. 4-fol...

journal_title：Biochemical and biophysical research communications

authors： McClenaghan NH,Barnett CR,Flatt PR

更新日期：1998-08-19 00:00:00

abstract：BACKGROUND:Research has indicated that Herba Patriniae can suppress the growth of Several kinds of tumor cells in vitro and in vivo, thus displaying favorable antitumor activity. However, research regarding the effect of saponins of Patrinia villosa against CRC cell has not been reported. In the current study, We have ...

journal_title：Biochemical and biophysical research communications

authors： Xia L,Zhang B,Yan Q,Ruan S

更新日期：2018-09-10 00:00:00

abstract：:Mitochondria has been identified as a promising target in several cancers. However, little is known on the effects of targeting mitochondria in retinoblastoma. In this work, we show that anti-malarial atovaquone, at clinically achievable concentration, demonstrates inhibitory effects to retinoblastoma cells, to a more...

journal_title：Biochemical and biophysical research communications

authors： Ke F,Yu J,Chen W,Si X,Li X,Yang F,Liao Y,Zuo Z

更新日期：2018-10-02 00:00:00

abstract：:Interactions between genes and environment play a critical role in the pathogenesis of type 2 diabetes. Low birth weight, due to genetic and environmental variables affecting fetal growth, is associated with increased susceptibility to the development of type 2 diabetes and metabolic disorders in adulthood. Clinical s...

journal_title：Biochemical and biophysical research communications

authors： Garg N,Thakur S,McMahan CA,Adamo ML

更新日期：2011-09-30 00:00:00

abstract：:LFA-1 (αLβ2) and Mac-1 (αMβ2) integrins regulate leukocyte trafficking in health and disease by binding primarily to IgSF ligand ICAM-1 and ICAM-2 on endothelial cells. Here we have shown that the anti-coagulant molecule thrombomodulin (TM), found on the surface of endothelial cells, functions as a potentially new lig...

journal_title：Biochemical and biophysical research communications

authors： Kawamoto E,Okamoto T,Takagi Y,Honda G,Suzuki K,Imai H,Shimaoka M

更新日期：2016-05-13 00:00:00

abstract：:The tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL or Apo2L) and its receptors are members of the tumor necrosis factor superfamily. TRAIL triggers apoptosis by binding to its two proapoptotic receptors DR4 and DR5, a process which is negatively regulated by binding of TRAIL to its two decoy rece...

journal_title：Biochemical and biophysical research communications

authors： Sun SY,Yue P,Zhou JY,Wang Y,Choi Kim HR,Lotan R,Wu GS

更新日期：2001-01-26 00:00:00

abstract：:Fatty acid binding protein 4 (FABP4) plays a key role in Fatty acid catabolism in mammals. Findings from our previous studies have indicated that FABP4 neither affect the differentiation of bovine preadipocytes nor does it change the expression of upstream genes. To investigate whether ectopically expressed FABP4 can ...

journal_title：Biochemical and biophysical research communications

authors： Zhang L,Zhao Y,Ning Y,Wang H,Zan L

更新日期：2017-01-08 00:00:00

abstract：:Pancreatic ductal carcinoma (PDC) remains one of the most intractable human malignancies. To obtain insight into the molecular pathogenesis of PDC, we constructed a retroviral cDNA expression library with total RNA isolated from the PDC cell line MiaPaCa-2. Screening of this library with the use of a focus formation a...

journal_title：Biochemical and biophysical research communications

authors： Fujiwara S,Yamashita Y,Choi YL,Wada T,Kaneda R,Takada S,Maruyama Y,Ozawa K,Mano H

更新日期：2005-12-16 00:00:00

abstract：:Human apoprotein(apo) CI and apo AII cDNA probes have been used to analyze the segregation of the human genes in panels of human-mouse hybrids. The apo CI (APOCI) gene segregates with chromosome 19 and the apo AII (APOA2) gene with chromosome 1. Somatic cell hybrids containing chromosome translocations were used to ma...

journal_title：Biochemical and biophysical research communications

authors： Knott TJ,Eddy RL,Robertson ME,Priestley LM,Scott J,Shows TB

更新日期：1984-11-30 00:00:00

abstract：:A patient with multiple fibromatosis occurring at the sites of multiple cartilagenous dysplasia was described. Collagen types solubilized with pepsin from the fibromatous tissue were fractionated by a different salt concentration and analyzed by SDS-polyacrylamide gel electrophoresis, which indicated that the tissue p...

journal_title：Biochemical and biophysical research communications

authors： Murata K,Motoyama T,Suka M,Ohno M,Kuboki Y

更新日期：1987-08-31 00:00:00

abstract：:CrkII is an intracellular adaptor protein involved in signal transduction by various growth factors. Activation of PDGF alpha-receptor resulted in its association with CrkII in vivo. In contrast, binding of CrkII to the PDGF beta-receptor was negligible, despite its becoming prominently phosphorylated. Bacterially exp...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto T,Yokote K,Take A,Takemoto M,Asaumi S,Hashimoto Y,Matsuda M,Saito Y,Mori S

更新日期：2000-04-02 00:00:00

abstract：:First messengers and viral transfection are the two most common ways to stimulate cells for signal output, although their applications are limited. We investigated mechanisms of inducing neural stem cell differentiation using recombinant ephrin-B2/Fc and found that it acted as a ligand and inhibited endogenous ephrin-...

journal_title：Biochemical and biophysical research communications

authors： Xiaodong H,Zhen H,Min S,Zhiming C,Hongyan J,Chong Z,Xuefeng T,Guohua J

更新日期：2013-10-18 00:00:00