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Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation.

Abstract：

:We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP(-/-) mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholesterol contents were only modestly decreased. Inflammation and fibrosis were suppressed in ChREBP(-/-) mice. In addition, compared with WD-fed WT mice, ChREBP(-/-) mice showed decreased β-oxidation, ketogenesis and FGF21 production, increased intestinal lipid absorption, and decreased VLDL secretion. These findings suggest that dietary fat and carbohydrate contribute differently to the development of fatty liver.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wu W,Tsuchida H,Kato T,Niwa H,Horikawa Y,Takeda J,Iizuka K

doi

10.1016/j.bbrc.2015.04.092

subject

Has Abstract

pub_date

2015-06-12 00:00:00

pages

681-6

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)00796-2

journal_volume

461

pub_type

杂志文章

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