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Alteration by v-Ki-ras in NaF, cholera toxin and forskolin-induced adenylate cyclase activation in NIH/3T3 fibroblast cells.

Abstract：

:It has been suggested that ras proteins are involved in the transmembrane signaling mechanism and they share structural features with GTP-binding proteins. To identify the role of ras oncogene and it's products in the coupling mechanisms of GTP-binding proteins to adenylate cyclase, we examined effect of NaF, cholera toxin and forskolin in normal and v-Ki-ras transformed NIH/3T3 fibroblast cells. In transformants, adenylate cyclase activity was markedly enhanced by NaF and cholera toxin, in contrast to normal cells. It is suggested that ras oncogene proteins plays enhancing role in coupling of GTP-binding proteins to adenylate cyclase.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Konishi-Imamura L,Noda M,Nomura Y

doi

10.1016/0006-291x(87)90688-7

subject

Has Abstract

pub_date

1987-07-15 00:00:00

pages

47-52

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90688-7

journal_volume

146

pub_type

杂志文章

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