GTP-binding membrane proteins in activated and differentiating T cells.

abstract：:On the basis of the well-known effect of ethanol poisoning on the prooxidant/antioxidant balance of human and rodent liver we tested the response of the mitochondrial manganese-containing superoxide dismutase (MnSOD) in the liver of rats following an acute ethanol load or chronically intoxicated with an alcohol-supple...

journal_title：Biochemical and biophysical research communications

authors： Koch OR,De Leo ME,Borrello S,Palombini G,Galeotti T

更新日期：1994-06-30 00:00:00

abstract：:Cancer stem cells (CSCs) play essential role in the progression of many tumors. Wnt/β-catenin pathway is crucial in maintaining the stemness of CSCs. (-)-Epigallocatechin-3-gallate (EGCG), the major bioactive component in green tea, has been shown to possess anti-cancer activity. To date, the interventional effect of ...

journal_title：Biochemical and biophysical research communications

authors： Zhu J,Jiang Y,Yang X,Wang S,Xie C,Li X,Li Y,Chen Y,Wang X,Meng Y,Zhu M,Wu R,Huang C,Ma X,Geng S,Wu J,Zhong C

更新日期：2017-01-01 00:00:00

abstract：:We examined the affinity of transthyretin (TTR) for lipoproteins and the effect of lipoproteins on TTR-related amyloidogenesis using serum samples from healthy volunteers and patients with familial amyloidotic polyneuropathy (FAP) ATTRVal30Met. In both volunteers and patients, TTR levels were highest in the VLDL fract...

journal_title：Biochemical and biophysical research communications

authors： Sun X,Ando Y,Haraoka K,Katsuragi S,Yamashita T,Yamashita S,Okajima M,Terazaki H,Okabe H

更新日期：2003-11-14 00:00:00

abstract：:Pyruvate kinase M2 (PKM2) is a key enzyme of glycolysis which is highly expressed in many tumor cells, and plays an important role in the Warburg effect. In previous study, we found PIM2 phosphorylates PKM2 at Thr454 residue (Yu, etl 2013). However, the functions of PKM2 Thr454 modification in cancer cells still remai...

journal_title：Biochemical and biophysical research communications

authors： Yu Z,Huang L,Qiao P,Jiang A,Wang L,Yang T,Tang S,Zhang W,Ren C

更新日期：2016-05-13 00:00:00

abstract：:Methylation-specific PCR (MSP) is frequently used to distinguish methylated alleles in the genome. Sequences that have been incompletely converted during bisulfite treatment are frequently co-amplified during MSP. For accurate MSP, it is important to detect methylated sequences in a background of unconverted DNA with ...

journal_title：Biochemical and biophysical research communications

authors： Sasaki M,Anast J,Bassett W,Kawakami T,Sakuragi N,Dahiya R

更新日期：2003-09-19 00:00:00

abstract：:The nucleotide sequence of the promoter region of the melibiose operon of E. coli was determined. Consensus sequences for the -35 region, the Pribnow box and the binding site for cyclic AMP receptor protein were found in this region. The possible secondary structure of this DNA region was very similar to that of the p...

journal_title：Biochemical and biophysical research communications

authors： Shimamoto T,Yazyu H,Futai M,Tsuchiya T

更新日期：1984-05-31 00:00:00

abstract：:Epicubenol and 19-hydroxyferruginol (Ferruginol) are sesquiterpenes isolated from the black heartwood of Cryptomeria japonica. Dendritic cells (DC) are specialized antigen-presenting cells that monitor the antigenic environment and activate naïve T cells. The role of DC is not only to sense danger but also to tolerize...

journal_title：Biochemical and biophysical research communications

authors： Takei M,Umeyama A,Arihara S

更新日期：2005-11-18 00:00:00

abstract：:Cachexia, observed in most cancer patients, is a syndrome that includes wasting of bodily energy reserves and is characterized by muscle atrophy and fat loss. We have previously demonstrated that isoflavones, such as genistein and daidzein, prevent muscle wasting in tumor-bearing mice. In this study, we examined the e...

journal_title：Biochemical and biophysical research communications

authors： Yoshimura T,Saitoh K,Sun L,Wang Y,Taniyama S,Yamaguchi K,Uchida T,Ohkubo T,Higashitani A,Nikawa T,Tachibana K,Hirasaka K

更新日期：2018-12-02 00:00:00

abstract：:The availability of a human lymphoma cell line deficient in adenosine deaminase, adenosine kinase and methylthioadenosine phosphorylase enabled us to compare the effects of nucleoside transport inhibitors on the excretion of endogenously generated adenosine, deoxyadenosine and 5'-methylthioadenosine. The nucleoside tr...

journal_title：Biochemical and biophysical research communications

authors： Iizasa T,Kubota M,Carson DA

更新日期：1984-06-15 00:00:00

abstract：:The adhesion of cancer cells to the extracellular matrix (ECM) is crucial for cell proliferation, survival, and metastasis. Thus, it is necessary to inhibit cell-ECM adhesion by blocking the activation of the associated signaling to control cancer. Here, we identify erybraedin A (EBA) as a potential Src inhibitor that...

journal_title：Biochemical and biophysical research communications

authors： Min HY,Jung Y,Park KH,Oh WK,Lee HY

更新日期：2018-07-07 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease caused by destruction of insulin-producing β cells. The response of autoreactive T cells to β cell antigens plays a central role in the development of T1D. Recently, fusion peptides composed by insulin C-peptide fragments and other proteins were reported as β cell target ...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto Y,Kishida K,Matsumoto M,Matsuoka S,Kohyama M,Suenaga T,Arase H

更新日期：2021-01-01 00:00:00

abstract：:PSI domains are cysteine-rich modules found in extracellular fragments of hundreds of signaling proteins, including plexins, semaphorins, integrins, and attractins. Here, we report the solution structure of the PSI domain from the human Met receptor, a receptor tyrosine kinase critical for proliferation, motility, and...

journal_title：Biochemical and biophysical research communications

authors： Kozlov G,Perreault A,Schrag JD,Park M,Cygler M,Gehring K,Ekiel I

更新日期：2004-08-13 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is recognized as a physiologic mediator produced in a variety of tissues. It is produced by three enzymes, cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST). However, the regulation of H(2)S production by CSE has not well been understoo...

journal_title：Biochemical and biophysical research communications

authors： Mikami Y,Shibuya N,Ogasawara Y,Kimura H

更新日期：2013-02-08 00:00:00

abstract：:NF-kappaB family of transcription factors are involved in numerous cellular processes, including differentiation, proliferation, and inflammation. It was reported that hydroxycinnamic acid derivatives (HADs) are inhibitors of NF-kappaB activation. Rice bran oil contains a lot of phytosteryl ferulates, one of HADs. We ...

journal_title：Biochemical and biophysical research communications

authors： Nagasaka R,Chotimarkorn C,Shafiqul IM,Hori M,Ozaki H,Ushio H

更新日期：2007-06-29 00:00:00

abstract：:The complex formation of two electron transfer proteins, cytochrome c3 and ferredoxin I from Desulfovibrio desulfuricans Norway, has been shown by 1H-NMR spectroscopy. Presence of ferredoxin I produces ferricytochrome c3 1H-NMR spectrum modifications. The chemical shift of perturbated heme methyl resonances has been u...

journal_title：Biochemical and biophysical research communications

authors： Guerlesquin F,Noailly M,Bruschi M

更新日期：1985-08-15 00:00:00

abstract：:Labelling of membrane phospholipids with 32P was compared in rat and rabbit aorta under basal conditions and during alpha 1-receptor stimulation. Incorporation of 32P proceeded at a significantly higher rate in rat tissue. The ratio of basal labelling following 30 min of incubation for rat/rabbit arteries was 4.8 for ...

journal_title：Biochemical and biophysical research communications

authors： Campbell MD,Danthuluri NR,Deth RC

更新日期：1986-12-30 00:00:00

abstract：:Eicosapentaenoic acid (EPA; 20:5 n-3; ethyl ester) in combination with atherogenic or non-atherogenic high fat diets was fed to young adult male marmoset monkeys for a period of 30 weeks. EPA markedly reduced the raised plasma cholesterol level evident when feeding an atherogenic diet but did not influence the cardiac...

journal_title：Biochemical and biophysical research communications

authors： Patten GS,Rinaldi JA,McMurchie EJ

更新日期：1989-07-31 00:00:00

abstract：:Since conventional chemotherapy (gemcitabine and cisplatin) has marginal survival benefit in patients with advanced cholangiocarcinoma (CCA), an effective targeted therapeutic agent is urgently required. Activation of the PI3K/Akt/mTOR signaling pathway is frequently observed in CCA, and thus, PI3K and mTOR are promis...

journal_title：Biochemical and biophysical research communications

authors： Jang DK,Lee YG,Chan Chae Y,Lee JK,Paik WH,Lee SH,Kim YT,Ryu JK

更新日期：2020-09-03 00:00:00

abstract：:Hepatitis C virus (HCV) causes chronic hepatitis C (CH-C) and is epidemiologically linked with the occurrence of hepatocellular carcinoma (HCC). To elucidate the comprehensive gene expression profiles of CH-C and HCC, serial analysis of gene expression (SAGE) libraries were made from CH-C and HCC tissues of a patient,...

journal_title：Biochemical and biophysical research communications

authors： Yamashita T,Kaneko S,Hashimoto S,Sato T,Nagai S,Toyoda N,Suzuki T,Kobayashi K,Matsushima K

更新日期：2001-03-30 00:00:00

abstract：:Apoptin, a small protein encoded by chicken anemia virus (CAV), induces cell death specifically in cancer cells. In normal cells, Apoptin remains in the cytoplasm; whereas in cancerous cells, it migrates into the nucleus and kills the cell. Cellular localization appears to be crucial. Through a yeast two-hybrid screen...

journal_title：Biochemical and biophysical research communications

authors： Huo DH,Yi LN,Yang J

更新日期：2008-07-18 00:00:00

abstract：:Bovine aorta endothelial cells were cultured in medium containing [3H]glucosamine, [35S]sulfate, and various concentrations of chlorate. Cell growth was not affected by 10 mM chlorate, while 30 mM chlorate had a slight inhibitory effect. Chlorate concentrations greater than 10 mM resulted in significant undersulfation...

journal_title：Biochemical and biophysical research communications

authors： Humphries DE,Silbert JE

更新日期：1988-07-15 00:00:00

abstract：:Diabetic cardiomyopathy represents severe heart complications, and is the leading cause of morbidity and mortality among patients with diabetes. Although a few microRNAs (miRNAs) have been implicated in diabetes-related complications, a functional association between miRNAs and cardiac dysfunction in diabetic cardiomy...

journal_title：Biochemical and biophysical research communications

authors： Qiao Y,Zhao Y,Liu Y,Ma N,Wang C,Zou J,Liu Z,Zhou Z,Han D,He J,Sun Q,Liu Y,Xu C,Du Z,Huang H

更新日期：2016-09-02 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders and is characterized by impaired attention, hyperactivity, and impulsivity. While multiple etiologies are implicated in ADHD, its underlying mechanism(s) remain unclear. Although previous studies have suggested dysre...

journal_title：Biochemical and biophysical research communications

authors： Nguyen Nguyen HT,Kato H,Sato H,Yamaza H,Sakai Y,Ohga S,Nonaka K,Masuda K

更新日期：2019-06-11 00:00:00

abstract：:A Golgi enriched fraction from rat brain was prepared. The preparation has no carboxypeptidase activity and is not contaminated with cytosol, mitochondria and lysosomes as judged by marker enzyme activities for these constituents. Associated with the Golgi membranes a putative opioid peptide processing activity was de...

journal_title：Biochemical and biophysical research communications

authors： Demmer W,Brand K

更新日期：1986-07-16 00:00:00

abstract：:Previous studies demonstrated that macrophages are difficult to transfect. In the present study, we investigated whether J774A.1 macrophages can be efficiently transfected using nucleofector technology. Nucleofection of J774A.1 macrophages with mRNA resulted in transfection efficiencies up to 75% without cell death as...

journal_title：Biochemical and biophysical research communications

authors： Van De Parre TJ,Martinet W,Schrijvers DM,Herman AG,De Meyer GR

更新日期：2005-02-04 00:00:00

abstract：:S-modulin is a 26 kDa protein that regulates light sensitivity of cGMP phosphodiesterase in a Ca(2+)-dependent manner in frog rod outer segments (ROSs). In the present study, we purified S-modulin by taking advantage of a hydrophobic interaction between Phenyl Sepharose and S-modulin at high Ca2+ concentrations. The y...

journal_title：Biochemical and biophysical research communications

authors： Kawamura S,Takamatsu K,Kitamura K

更新日期：1992-07-15 00:00:00

abstract：:Interleukin (IL)-18 bioactivity and dsRNA sensing by receptors of innate immunity are key components of anti-viral host defense. Despite extensive data on signal transduction activated by both pathways knowledge on cross-communication is incomplete. By using human PBMC and predendritic KG1 cells, as prototypic IL-18-r...

journal_title：Biochemical and biophysical research communications

authors： Balah A,Akool el-S,Bachmann M,Pfeilschifter J,Mühl H

更新日期：2009-11-27 00:00:00

abstract：:Nitrous oxide affects dioxygen utilization by both bean seed and bovine heart submitochondrial particles when either succinate or reduced cytochrome c are used as substrates. Bovine heart particles exhibit reversible, dose-dependent partial inhibition of respiratory activity when exposed to N2O. Bean seed particle res...

journal_title：Biochemical and biophysical research communications

authors： Sowa S,Dong A,Roos EE,Caughey WS

更新日期：1987-04-29 00:00:00

abstract：:Pseudouridine in yeast 5S RNA was modified with 4-bromomethyl-7-methoxy-coumarin(BMC). Temperature dependence of fluorescence intensity was measured at various concentrations of Mg2+ and K+ cations. Hyperchromicity was also measured. At 100mM KCl and 10mM Mg2+, fluorescence intensity decreased with temperature as free...

journal_title：Biochemical and biophysical research communications

authors： Nagamatsu K,Miyazawa Y

更新日期：1983-07-18 00:00:00

abstract：:The transcription factor hypoxia-inducible factor-1 (HIF-1) functions as a master regulator of hypoxic response by inducing the transcription of various genes responsible for cellular adaptation to hypoxia. In this study, we investigated the effects of protein inhibitor of activated STAT3 (PIAS3), a small ubiquitin-re...

journal_title：Biochemical and biophysical research communications

authors： Nakagawa K,Kohara T,Uehata Y,Miyakawa Y,Sato-Ueshima M,Okubo N,Asaka M,Takeda H,Kobayashi M

更新日期：2016-01-15 00:00:00