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Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells.

Abstract：

:The process of endochondral ossification is strictly regulated by a variety of extracellular and intracellular factors. Recently, it has become recognized that specific miRNAs are involved in this process by regulating the expression of the relevant genes at the post-transcriptional level. In this present study we obtained the first evidence of the involvement of a specific micro RNA (miRNA) in the regulation of the chondrocyte phenotype during late stages of differentiation. By use of the microarray technique, miR-1 was identified as this miRNA, the expression of which was most repressed upon hypertrophic differentiation. Transfection of human chondrocytic HCS-2/8 cells and chicken normal chondrocytes with miR-1 led to repressed expression of aggrecan, the major cartilaginous proteoglycan gene. Therefore, miR-1 was found to be involved in the regulation of the chondrocytic phenotype and thus to play an important role in chondrocytes during the late stage of the differentiation process, maintaining the integrity of the cartilage tissue.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sumiyoshi K,Kubota S,Ohgawara T,Kawata K,Nishida T,Shimo T,Yamashiro T,Takigawa M

doi

10.1016/j.bbrc.2010.10.016

subject

Has Abstract

pub_date

2010-11-12 00:00:00

pages

286-90

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)01867-X

journal_volume

402

pub_type

杂志文章

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