Role of interleukin-3 in the regulation of intracellular K+ homeostasis in cultured murine haemopoietic cells.

abstract：:Atriopeptin (AP) is synthesized and stored in the mammalian atria as a 126 amino acid prohormone (AP126). Upon secretion, the prohormone undergoes site specific proteolysis within the atria to yield the carboxyl terminal 28 amino acid hormone (AP28). The atrial cell responsible for AP126 bioactivation has not yet been...

journal_title：Biochemical and biophysical research communications

authors： Greenwald JE,Needleman P,Siegel N,Tetens E,Biel B,Ritter D

更新日期：1992-10-30 00:00:00

abstract：:Studies have shown similarities between the histopathological characteristics of NPC and Alzheimer's disease (AD) including amyloid and tau pathologies. While dysfunction in insulin signaling was widely detected in AD brain, the function of insulin signaling proteins has not been examined in NPC disease. In this study...

journal_title：Biochemical and biophysical research communications

authors： Ong QR,Lim ML,Chua CC,Cheung NS,Wong BS

更新日期：2012-08-03 00:00:00

abstract：:NO production in platelets has been followed by electrochemical detection. It was undetectable in unstimulated platelets and in thrombin or ADP-stimulated platelets, but dose-dependently stimulated by collagen. A production of 5 10(-19) mol/platelet was reached with 9 micrograms collagen. In collagen-stimulated platel...

journal_title：Biochemical and biophysical research communications

authors： Lantoine F,Brunet A,Bedioui F,Devynck J,Devynck MA

更新日期：1995-10-24 00:00:00

abstract：:Reduction of the four Fe centers is not required to initiate the reaction of the Halomonas halodenitrificans nitric oxide reductase (NOR) based on the facts that NOR in the form that ferric heme b(3) and non-heme iron (Fe(B)) are not bridged and/or the interaction between them is weakened and reversibly binds NO molec...

journal_title：Biochemical and biophysical research communications

authors： Sakurai T,Nakashima S,Kataoka K,Seo D,Sakurai N

更新日期：2005-07-29 00:00:00

abstract：:Bortezomib (BTZ) is one of the most frequently used drugs in treatment of multiple myeloma (MM), but drug-resistance often occurs and limits its clinical efficacy. Annexin A1 (ANXA1) is upregulated in MM, and its knockdown enhances chemosensitivity in MM. However, whether ANXA1 inhibition can increase antitumor activi...

journal_title：Biochemical and biophysical research communications

authors： Jia C,Kong D,Guo Y,Li L,Quan L

更新日期：2018-11-02 00:00:00

abstract：:Endothelial growth factors have become the target of intense research since the initial discovery of vascular endothelial growth factor (VEGF/VPF). At present, VEGF is established as a major inducer of angiogenesis in normal and pathological conditions. Recently several new members in the VEGF family have been describ...

journal_title：Biochemical and biophysical research communications

authors： Farnebo F,Piehl F,Lagercrantz J

更新日期：1999-04-21 00:00:00

abstract：:The clinical effects of serpin polymerisation include thromboembolism, emphysema, and liver disease. A through understanding of serpin polymerisation mechanisms and the structures involved will permit the rational design of therapeutic polymerisation inhibitors. Here we show that serpin polymerisation can be delayed b...

journal_title：Biochemical and biophysical research communications

authors： Bottomley SP,Chang WS

更新日期：1997-12-18 00:00:00

abstract：:Enzymatic lipid peroxidation in hepatocytes is believed to involve cytochrome P450. cAMP dependent phosphorylation of cytochrome P450 was found to increase the NADPH dependent production of malondialdehyde (lipid peroxidation) by about 30%. The cytochrome P450 inhibitor cyanide abolished this activity. The presence of...

journal_title：Biochemical and biophysical research communications

authors： Mkrtchian SL,Andersson KK

更新日期：1990-01-30 00:00:00

abstract：:Auxins regulate various aspects of plant growth and development. However, the mechanism by which these hormones elicit diverse physiological processes is not clear. We present evidence for the role of auxin in protein phosphorylation and the possible involvement of calmodulin in auxin-induced changes. In the presence ...

journal_title：Biochemical and biophysical research communications

authors： Reddy AS,Chengappa S,Poovaiah BW

更新日期：1987-04-29 00:00:00

abstract：:Gene delivery has become an important tool for biological research and gene therapy trials. Lentiviral vector (LV) mediated gene transfer is a preferred approach for stable, sustained transgenic expression. We report here step-wise development of an Indian human immunodeficiency virus type 2 (HIV-2) isolate derived th...

journal_title：Biochemical and biophysical research communications

authors： Santhosh CV,Tamhane MC,Kamat RH,Patel VV,Mukhopadhyaya R

更新日期：2008-07-04 00:00:00

abstract：:The ability to prevent methylene blue (MB), a photosensitizer, from being reduced by plasma reductases will greatly improve its efficacy in photodynamic therapy (PDT) applications. We have developed a delivery approach for PDT by encapsulating MB using nanoparticle platforms (NPs). The 30-nm polyacrylamide-based NPs p...

journal_title：Biochemical and biophysical research communications

authors： Tang W,Xu H,Park EJ,Philbert MA,Kopelman R

更新日期：2008-05-02 00:00:00

abstract：:The adhesion of cancer cells to the extracellular matrix (ECM) is crucial for cell proliferation, survival, and metastasis. Thus, it is necessary to inhibit cell-ECM adhesion by blocking the activation of the associated signaling to control cancer. Here, we identify erybraedin A (EBA) as a potential Src inhibitor that...

journal_title：Biochemical and biophysical research communications

authors： Min HY,Jung Y,Park KH,Oh WK,Lee HY

更新日期：2018-07-07 00:00:00

abstract：:Little is known about an oncogenic signal transducer β-1,4-galactosyltransferase-V (β-1,4-GalT-V), in human colorectal cancer. Using quantitative RT-PCR, immunohistochemical staining and ELISA assays, we determined that β-1,4-GalT-V gene/protein expression is specifically increased in human colorectal cancer (CRC) tum...

journal_title：Biochemical and biophysical research communications

authors： Chatterjee SB,Hou J,Bandaru VVR,Pezhouh MK,Syed Rifat Mannan AA,Sharma R

更新日期：2019-01-08 00:00:00

abstract：:Increased ubiquitin-specific protease 5 (USP5) has been associated with tumorigenesis of malignancy including glioblastoma, melanoma and hepatocellular carcinoma. However, the role of USP5 in tumorigenesis of pancreatic ductal adenocarcinoma (PDAC) has not been studied yet. In this study, we demonstrated that USP5 was...

journal_title：Biochemical and biophysical research communications

authors： Li XY,Wu HY,Mao XF,Jiang LX,Wang YX

更新日期：2017-10-07 00:00:00

abstract：:We investigated the influence of the relative abundance of insulin and IGF-1 receptors on cellular growth, by measuring the stimulation of c-fos expression and of H3-thymidine incorporation into DNA by insulin and IGF-1 in CHO cells overexpressing insulin Receptor (CHO-IR). We found that CHO-IR cells were resistant to...

journal_title：Biochemical and biophysical research communications

authors： Maggi D,Laurino C,Andraghetti G,Cordera R

更新日期：1994-11-30 00:00:00

abstract：:Specifier proteins are important components of the glucosinolate-myrosinase system, which mediate plant defense against herbivory and pathogen attacks. Upon tissue disruption, glucosinolates are hydrolyzed to instable aglucones by myrosinases, and then aglucones will rearrange to form defensive isothiocyanates. Specif...

journal_title：Biochemical and biophysical research communications

authors： Zhang W,Wang W,Liu Z,Xie Y,Wang H,Mu Y,Huang Y,Feng Y

更新日期：2016-09-16 00:00:00

abstract：:The endoplasmic reticulum (ER) is an organelle in which most membrane and secretory proteins are synthesized. If these proteins are not folded correctly, unfolded proteins accumulate in the ER lumen, causing a cellular situation known as ER stress. Recently, many studies on the relationship between ER stress and disea...

journal_title：Biochemical and biophysical research communications

authors： Hosoda A,Maruyama A,Oikawa D,Oshima Y,Komachi Y,Kanai G,Sato H,Iwawaki T

更新日期：2011-02-04 00:00:00

abstract：:Pluripotent human embryonic stem cells (hESCs) have the distinguishing feature of innate capacity to allow indefinite self-renewal. This attribute continues until specific constraints or restrictions, such as DNA methylation, are imposed on the genome, usually accompanied by differentiation. With the aim of utilizing ...

journal_title：Biochemical and biophysical research communications

authors： Yeo S,Jeong S,Kim J,Han JS,Han YM,Kang YK

更新日期：2007-08-03 00:00:00

abstract：:Ovarian cancer (OC) is one of the most prevalent cancers with high fatality rate. In the present study, RT-PCR showed that the mRNA level of CDKN2B-AS1 was significantly upregulated while the miR-411-3p was downregulated in OC cell lines. In addition, the Sh-CDKN2B-AS1 resulted in the suppression of cell growth, invas...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Huang Y,Liu H,Su D,Luo F,Zhou F

更新日期：2019-06-18 00:00:00

abstract：:We identified human decapping enzyme 2 (hDCP2) as a binding protein with Ro52, being colocalized in processing bodies (p-bodies). We also showed that the N-terminus and C-terminus of Ro52 bound to hDCP2. Moreover, Ro52 enhanced decapping activity of hDCP2 in a dose-dependent manner. Our data support the novel notion o...

journal_title：Biochemical and biophysical research communications

authors： Yamochi T,Ohnuma K,Hosono O,Tanaka H,Kanai Y,Morimoto C

更新日期：2008-05-23 00:00:00

abstract：:Gut microbiota is critical for maintaining body immune homeostasis and thus affects tumor growth and therapeutic efficiency. Here, we investigated the link between microbiota and tumorgenesis in a mice model of subcutaneous melanoma cell transplantation, and explored the underlying mechanism. We found disruption of gu...

journal_title：Biochemical and biophysical research communications

authors： Xu C,Ruan B,Jiang Y,Xue T,Wang Z,Lu H,Wei M,Wang S,Ye Z,Zhai D,Wang L,Lu Z

更新日期：2017-06-24 00:00:00

abstract：:The synthetic (1-->6)-alpha-D-glucopyranan with branching and without branching were tested as a new hypoglycaemic drug. (1-->6)-alpha-D-glucopyranan having an alpha-D-glucopyranosyl branch at the C-3 position (1) showed a remarkable hypoglycaemic activity on i.p. injection to mice. The polysaccharide having both alph...

journal_title：Biochemical and biophysical research communications

authors： Hatanaka K,Song SC,Maruyama A,Kobayashi A,Kuzuhara H,Akaike T

更新日期：1992-10-15 00:00:00

abstract：:Rat adrenocortical cells in culture respond to stimulation by ACTH alone (15 fold over basal) and to ACTH + added lipoproteins (as an exogeneous source of cholesterol), with an additional 25-30 fold rise in steroidogenesis. With the addition of okadaic acid (OKA, 100 nM), a potent protein phosphatase inhibitor, the li...

journal_title：Biochemical and biophysical research communications

authors： Azhar S,Wang H,Tsai L,Reaven E

更新日期：1991-09-16 00:00:00

abstract：:Cripto-1 (CR-1) is a transforming growth factor which has been associated with breast, colon, and pancreatic cancer. Overexpression of CR-1 in non-tumorigenic mouse mammary epithelial cells and fibroblasts results in an increase in anchorage-dependent and -independent growth in vitro. Reduction of CR-1 expression in h...

journal_title：Biochemical and biophysical research communications

authors： Kintner RL,Hosick HL

更新日期：1998-04-28 00:00:00

abstract：:Adipose tissue is an endocrine organ that produces and secretes adipokines. The aim of this study was to identify genes predominantly expressed in human subcutaneous adipocytes. For this purpose, an algorithm was developed and DNA microarray expression profiles from 33 human tissues and cell types were used to select ...

journal_title：Biochemical and biophysical research communications

authors： Sjöholm K,Palming J,Lystig TC,Jennische E,Woodruff TK,Carlsson B,Carlsson LM

更新日期：2006-06-16 00:00:00

abstract：:Chromatography of a rat liver extract on DEAE-cellulose resulted in the near total loss of 3-hydroxyacyl-CoA epimerase activity. The activity was regained either when fractions were recombined or when purified crotonase was added to the early column fractions. A new enoyl-CoA hydratase present in these early fractions...

journal_title：Biochemical and biophysical research communications

authors： Smeland TE,Li JX,Chu CH,Cuebas D,Schulz H

更新日期：1989-05-15 00:00:00

abstract：:Native microorganisms in their original form cannot be patented. However, microbes like yeasts, bacteria, protozoa, unicellular algae, fungi, actinomycetes and viruses can be patented if they have been genetically modified. The process and the product obtained can also be patented. ...

journal_title：Biochemical and biophysical research communications

authors： Cameotra SS

更新日期：2013-01-04 00:00:00

abstract：:Human AlkB homolog 8 (ALKBH8) is highly expressed in high-grade, superficially and deeply invasive bladder cancer. Moreover, ALKBH8 knockdown induces apoptosis in bladder cancer cells. However, the underlying anti-apoptotic mechanism of ALKBH8 in bladder cancer cells has thus far remained unclear. Moreover, there is n...

journal_title：Biochemical and biophysical research communications

authors： Ohshio I,Kawakami R,Tsukada Y,Nakajima K,Kitae K,Shimanoe T,Saigo Y,Hase H,Ueda Y,Jingushi K,Tsujikawa K

更新日期：2016-08-26 00:00:00

abstract：:cDNA clones from Nicotiana plumbaginifolia have been isolated by hybridization to a yeast H+-ATPase gene. The largest one encodes a polypeptide (PMA2) of 956 amino acid residues which exhibits a homology of 73% with a limited protein sequence obtained from purified oat plasma membrane H+-ATPase (Schaller and Sussman, ...

journal_title：Biochemical and biophysical research communications

authors： Boutry M,Michelet B,Goffeau A

更新日期：1989-07-31 00:00:00

abstract：:Extracellular calcium-deprivation inhibited the proliferation of BALB/c 3T3 cells and this inhibition correlated with a loss of protein kinase C activity from the particulate fraction. Addition of calcium induced proliferation of the cells with the DNA synthetic activity returning to the control rate at 18 hours follo...

journal_title：Biochemical and biophysical research communications

authors： Donnelly TE Jr,Sittler R,Scholar EM

更新日期：1985-01-31 00:00:00