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Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness.

Abstract：

:The ability to prevent methylene blue (MB), a photosensitizer, from being reduced by plasma reductases will greatly improve its efficacy in photodynamic therapy (PDT) applications. We have developed a delivery approach for PDT by encapsulating MB using nanoparticle platforms (NPs). The 30-nm polyacrylamide-based NPs provide protection for the embedded MB against reduction by diaphorase enzymes. Furthermore, our data shows the matrix-protected MB efficiently induces photodynamic damage to tumor cells. The unprecedented results demonstrate the significant in vitro photodynamic effectiveness of MB when encapsulated within NPs, which promises to open new opportunities for MB in its in vivo and clinical studies.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tang W,Xu H,Park EJ,Philbert MA,Kopelman R

doi

10.1016/j.bbrc.2008.02.066

subject

Has Abstract

pub_date

2008-05-02 00:00:00

pages

579-83

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)00316-1

journal_volume

369

pub_type

杂志文章

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