TLE, the human homolog of groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation.

abstract：:The root-knot nematode (RKN) Meloidogyne incognita reproduces on the roots of tobacco (Nicotiana tabacum), damaging crops, reducing crop yield, and causing economic losses annually. The development of resistant genotypes is an alternative strategy to effectively control these losses. However, the molecular mechanism r...

journal_title：Biochemical and biophysical research communications

authors： Xing X,Li X,Zhang M,Wang Y,Liu B,Xi Q,Zhao K,Wu Y,Yang T

更新日期：2017-01-22 00:00:00

abstract：:The corticotropin releasing factor (CRF) plays a central role in regulating the activities of hypothalamic-pituitary-adrenal (HPA) axis in the presence of a variety of stressful stimuli via binding to its type 1 receptors (CRFR1). Despite that many peptidic or non-peptidic antagonists of CRFR1 have been developed to s...

journal_title：Biochemical and biophysical research communications

authors： Yu J,Zhuo R,Peng P,Liu X,Yan H,Zhang S,Zheng J,Wei X,Ma X

更新日期：2015-07-31 00:00:00

abstract：:Circulating human mononuclear blood cells were studied for the presence of specific 1,25-dihydroxyvitamin D3 (calcitriol) binding macromolecules. Cells were isolated by density gradient centrifugation and characterized by surface markers. Specific reversible high affinity binding by a 3.5 S macromolecule was demonstra...

journal_title：Biochemical and biophysical research communications

authors： Merke J,Senst S,Ritz E

更新日期：1984-04-16 00:00:00

abstract：:The effects of the small noncatalytic subunit of myosin light chain phosphatase (MLCPsr) on the Ca2+-induced contraction of smooth muscle were investigated in the Triton X-100-permeabilized porcine renal artery. The full-length recombinant chicken MLCPsr obtained by the bacterial expression system induced an additiona...

journal_title：Biochemical and biophysical research communications

authors： Zhou Y,Nishimura J,Hirano K,Kanaide H

更新日期：1999-01-08 00:00:00

abstract：:Previous investigations in our laboratory demonstrated the existence of an intrinsic mechanism, termed membrane modulation, capable of restoring sensitivity to aspirin treated platelets, resulting in irreversible aggregation in response to arachidonic acid (AA). The mechanism underlying correction of aspirin induced i...

journal_title：Biochemical and biophysical research communications

authors： Rao GH,Radha E,White JG

更新日期：1985-08-30 00:00:00

abstract：:The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted alpha-helix-turn-alpha-helix structures and two sequences each o...

journal_title：Biochemical and biophysical research communications

authors： Uchida K,Morita T,Sato T,Ogura T,Yamashita R,Noguchi S,Suzuki H,Nyunoya H,Miwa M,Sugimura T

更新日期：1987-10-29 00:00:00

abstract：:p73 is a member of the p53 family of transcription factors which plays an essential role in tumor suppression. p73 is associated with the sensitivity of cancer cells to chemotherapy and the prognosis of many cancers. In this study, we showed the ubiquitination-dependent degradation of p73 by the mitochondrial E3 ubiqu...

journal_title：Biochemical and biophysical research communications

authors： Min B,Ryu J,Chi SW,Yi GS

更新日期：2015-11-13 00:00:00

abstract：:Increased protein tyrosyl phosphorylation in response to growth factors has been assumed to be solely due to activation of protein tyrosine kinases (PTKs). We report that total cellular protein tyrosine phosphatase (PTPase) activity declined in MDA-MB 468 breast carcinoma cells exposed to epidermal growth factor (EGF)...

journal_title：Biochemical and biophysical research communications

authors： Mishra S,Hamburger AW

更新日期：1993-03-31 00:00:00

abstract：:The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid seq...

journal_title：Biochemical and biophysical research communications

authors： Yamada T,Sasaki H,Furuya H,Miyata T,Goto I,Sakaki Y

更新日期：1987-12-16 00:00:00

abstract：:Osterix (Osx) has been shown to be an osteoblast-specific transcription factor for bone formation. Recently, it has been reported that Osx is significantly expressed in the mouse olfactory bulb, proving that Osx may play a role in olfactory bulb development, as well as bone development. Here, we studied morphological ...

journal_title：Biochemical and biophysical research communications

authors： Park JS,Park GI,Kim JE

更新日期：2016-09-09 00:00:00

abstract：:Current therapeutic approaches for Parkinson's disease (PD) provide symptomatic relief but none of them change the course of disease. There is therefore a clear need for regenerative and cell replacement therapies (CRT). However, CRT faces several important challenges. First, the main symptoms of PD result from the lo...

journal_title：Biochemical and biophysical research communications

authors： Arenas E

更新日期：2010-05-21 00:00:00

abstract：:The ability of paraquat, MPP+, and analogs to be reduced by chemical reductants and by NADPH, as catalyzed by liver microsomes or purified NADPH cytochrome P-450 reductase, is reported. The analogs span a range of electrochemical potential, including values in-between that of paraquat and MPP+. Analogs with an Eo belo...

journal_title：Biochemical and biophysical research communications

authors： Frank DM,Arora PK,Blumer JL,Sayre LM

更新日期：1987-09-30 00:00:00

abstract：:The effect of several agents known to interact with muscarinic acetylcholine receptors on the release of choline from slices of rat corpus striatum into the incubation medium has been investigated. The amount of released choline was increased if choline, acetylcholine, or oxotremorine had been added to the incubation ...

journal_title：Biochemical and biophysical research communications

authors： Dolezal V,Tucek S

更新日期：1984-05-16 00:00:00

abstract：:The use of combined hormone replacement therapy (HRT) with oestrogens and progestins in postmenopausal women has been associated with an increased risk for developing breast cancer. The reasons are not fully understood, but influence of HRT on endogenous conversion of female sex hormones may be involved. The expressio...

journal_title：Biochemical and biophysical research communications

authors： Sivik T,Jansson A

更新日期：2012-05-25 00:00:00

abstract：:Transforming growth factor-β (TGF-β) signaling has been significantly implicated in the pathogenesis of aneurysm, prominently the initiation and progression of abdominal aortic aneurysm (AAA). Vascular smooth muscle cell (SMC) is the principal resident cell in aortic wall and is essential for its structure and functio...

journal_title：Biochemical and biophysical research communications

authors： Gao F,Chambon P,Offermanns S,Tellides G,Kong W,Zhang X,Li W

更新日期：2014-11-07 00:00:00

abstract：:The author found a sugar-containing 70 KDa factor in rat liver nuclei as described in the previous report (1), which repressed RNA chain initiation by all classes of rat liver RNA polymerases and specifically stimulated chromatin-dependent RNA chain elongation catalyzed by RNA polymerase II. In this communication, the...

journal_title：Biochemical and biophysical research communications

authors： Okai Y

更新日期：1984-11-30 00:00:00

abstract：:Histidine decarboxylase gene (HDC) encodes histidine decarboxylase which is the crucial enzyme for the biosynthesis of histidine. Studies have shown that histamine is likely to be involved in the regulation of reproduction system. To find the possible correlation between HDC gene and AANM (age at natural menopause), w...

journal_title：Biochemical and biophysical research communications

authors： Zhang F,Xiong DH,Wang W,Shen H,Xiao P,Yang F,Recker RR,Deng HW

更新日期：2006-10-06 00:00:00

abstract：:Hippocampal slices offer an excellent experimental system for the study of activity-induced changes in the postsynaptic density (PSD). While studies have documented electrophysiological and structural changes at synapses in response to precise manipulations of hippocampal slices, parallel biochemical and proteomic ana...

journal_title：Biochemical and biophysical research communications

authors： Dosemeci A,Tao-Cheng JH,Vinade L,Jaffe H

更新日期：2006-01-13 00:00:00

abstract：:A novel cDNA clone was isolated from a yeast Saccharomyces cerevisiae lambda gt11 cDNA library using rabbit anti-rat tropomyosin (TM30nm) polyclonal antibody (RTM8-2). It consists of an open reading frame of 951 bp, encoding 317 amino acid residues. The putative sequence recognized by RTM8-2 was present in Asn-235 to ...

journal_title：Biochemical and biophysical research communications

authors： Miyado K,Katsuki M,Taniguchi S

更新日期：1994-03-30 00:00:00

abstract：:Atrazine is a widely used triazine herbicide. Although controversy still exists, a number of recent studies have described its adverse effects on various animals including humans. Of particular interest is its effects on reproductive capacity. In this study, we investigated the mechanisms underlying the adverse effect...

journal_title：Biochemical and biophysical research communications

authors： Hase Y,Tatsuno M,Nishi T,Kataoka K,Kabe Y,Yamaguchi Y,Ozawa N,Natori M,Handa H,Watanabe H

更新日期：2008-02-01 00:00:00

abstract：:Two novel subtilisin-like serine proteases (AS-E1 and -E2) that activate prothrombin have been identified in a culture of the fungus Acremonium sp. The enzymes were purified through repeated hydrophobic interaction chromatography. The N-terminal sequences of AS-E1 (34.4 kDa) and AS-E2 (32 kDa) showed high similarity t...

journal_title：Biochemical and biophysical research communications

authors： Liu C,Matsushita Y,Shimizu K,Makimura K,Hasumi K

更新日期：2007-06-22 00:00:00

abstract：:Rat hearts were perfused for 15min with buffer equilibrated with 0.01% or 0.05% CO. The buffer was equilibrated with 21% O(2) throughout. The ventricular glutathione content decreased by 76% and 84%, 90min post-exposure to 0.01% and 0.05% CO, respectively, compared with 0% CO controls (0.45+/-0.01 micromol/g wet tissu...

journal_title：Biochemical and biophysical research communications

authors： Patel AP,John Moody A,Handy RD,Robert Sneyd J

更新日期：2003-03-07 00:00:00

abstract：:Several studies support a role for the multiple tumor suppressor gene (MTS1) in the malignant progression of different tumor types. In this study we have examined the status of the MTS1 gene in a variety of non-astrocytic tumors of the central nervous system. It was not possible, using multiplex PCR with primers for M...

journal_title：Biochemical and biophysical research communications

authors： Walker DG,Duan W,Kaye AH,Lavin MF

更新日期：1995-06-15 00:00:00

abstract：:Arsenic trioxide (ATO) is remarkably effective for treating acute promyelocytic leukemia. Here, we find that ATO treatment of NB4 and K562 leukemic cells induces activation of ASK1. ASK1 activation was induced most significantly at low concentrations of ATO, where G2/M arrest but not apoptosis was induced. On the othe...

journal_title：Biochemical and biophysical research communications

authors： Yan W,Arai A,Aoki M,Ichijo H,Miura O

更新日期：2007-04-20 00:00:00

abstract：:Chondroitin sulfate proteoglycan 4 (CSPG4), a transmembrane proteoglycan originally identified in melanoma cells, has been reported to be expressed in breast cancer cells. This study was performed to examine the expression and significance of CSPG4 in a cohort of breast cancer patients. Immunohistochemical analysis of...

journal_title：Biochemical and biophysical research communications

authors： Hsu NC,Nien PY,Yokoyama KK,Chu PY,Hou MF

更新日期：2013-11-15 00:00:00

abstract：:Apolipoprotein B (apoB) mRNA editing involves a site-specific cytidine to uridine transition catalyzed by the cytidine deaminase, APOBEC-1, in the context of and regulated by a multi-protein-containing editosome. ApoB mRNA editing in vivo is subject to tissue specific, developmental and metabolic regulation. We demons...

journal_title：Biochemical and biophysical research communications

authors： Van Mater D,Sowden MP,Cianci J,Sparks JD,Sparks CE,Ballatori N,Smith HC

更新日期：1998-11-18 00:00:00

abstract：:The mechanism of transcriptional repression by nuclear hormone receptors, especially in the presence of the ligands, is largely unknown. We previously reported that 1,25-dihydroxyvitamin D(3) (1,25 vitamin D3) inhibited expression of the parathyroid hormone-related polypeptide (PTHrP) gene through the interaction betw...

journal_title：Biochemical and biophysical research communications

authors： Okazaki T,Nishimori S,Ogata E,Fujita T

更新日期：2003-05-16 00:00:00

abstract：:The genetic encoding of synthetic or "non-natural" amino acids promises to diversify the functions and structures of proteins. We applied rapid codon-reassignment for creating Escherichia coli strains unable to terminate translation at the UAG "stop" triplet, but efficiently decoding it as various tyrosine and lysine ...

journal_title：Biochemical and biophysical research communications

authors： Mukai T,Yanagisawa T,Ohtake K,Wakamori M,Adachi J,Hino N,Sato A,Kobayashi T,Hayashi A,Shirouzu M,Umehara T,Yokoyama S,Sakamoto K

更新日期：2011-08-12 00:00:00

abstract：:Sepsis-induced muscle proteolysis mainly reflects ubiquitin-proteasome-dependent protein degradation. The effect of in vivo administration of a proteasome inhibitor on muscle protein breakdown during sepsis is not known. We treated rats with the proteasome inhibitor N-benzyloxycarbonyl-Ile-Glu-(O-t-butyl)-Ala-leucinal...

journal_title：Biochemical and biophysical research communications

authors： Fischer D,Gang G,Pritts T,Hasselgren PO

更新日期：2000-04-02 00:00:00

abstract：:Behcet's disease (BD) is a chronic relapsing inflammatory autoimmune disease characterized by recurrent oral and genital ulcers, skin legions and uveitis and its pathogenesis is not fully elucidated. Previously we identified that two novel susceptible SNPs are associated with BD. One is located in putative RNF39 promo...

journal_title：Biochemical and biophysical research communications

authors： Kurata R,Tajima A,Yonezawa T,Inoko H

更新日期：2013-06-21 00:00:00