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The exogenously added small subunit of smooth muscle myosin phosphatase increases the Ca2+ sensitivity of the contractile apparatus in the permeabilized porcine renal artery.

Abstract：

:The effects of the small noncatalytic subunit of myosin light chain phosphatase (MLCPsr) on the Ca2+-induced contraction of smooth muscle were investigated in the Triton X-100-permeabilized porcine renal artery. The full-length recombinant chicken MLCPsr obtained by the bacterial expression system induced an additional contraction at a constant [Ca2+]i and shifted the [Ca2+]i-force relation curve to the left. A deletion mutant containing the N-terminal 78 amino acids of MLCPsr retained the full action, compared with the full-length MLCPsr, while the deletion of this region completely abolished its effect. The process of relaxation was also delayed by the fragment containing the N-terminal 78 amino acids. These results indicated that MLCPsr increases the Ca2+ sensitivity of the contractile apparatus while the N-terminal 78 amino acids are responsible for this effect in vascular smooth muscle.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zhou Y,Nishimura J,Hirano K,Kanaide H

doi

10.1006/bbrc.1998.9915

subject

Has Abstract

pub_date

1999-01-08 00:00:00

pages

158-63

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)99915-6

journal_volume

254

pub_type

杂志文章

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