A putative sirolimus (rapamycin) effector protein.

Abstract:

:Sirolimus (rapamycin), a new immunosuppressive drug, inhibits proliferation of a wide spectrum of T and B cells. The immunosuppressive mechanism of sirolimus is still unclear. We recently isolated a membrane associated protein with an apparent molecular weight of 210 kDa, p210, from cultured Molt 4 cells and BJAB cells and from normal human T cells using an affinity matrix method. The p210 binds to sirolimus:FKBP12 complex, but only at background levels to FKBP12 alone, to FK506:FKBP12 complex, or sirolimus-biotin alone. Among the sirolimus analogs tested, the binding ability of p210 to drug:FKBP12 complexes correlates with the immunosuppressive activity of the drugs, suggesting that p210 is the sirolimus effector protein.

authors

Chen Y,Chen H,Rhoad AE,Warner L,Caggiano TJ,Failli A,Zhang H,Hsiao CL,Nakanishi K,Molnar-Kimber KL

doi

10.1006/bbrc.1994.2140

subject

Has Abstract

pub_date

1994-08-30 00:00:00

pages

1-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X84721401

journal_volume

203

pub_type

杂志文章
  • FAK mediates the inhibition of glioma cell migration by truncated 24 kDa FGF-2.

    abstract::A truncated form of 24kDa FGF-2 consisting of 86 NH(2)-terminal amino acids (ATE+31) inhibits cell migration in vitro and tumor development and angiogenesis in vivo. Focal adhesion kinase (FAK) is phosphorylated on tyrosine and serine sites after cell stimulation by growth factors. This study examined the effect of AT...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2009.03.084

    authors: Lin AH,Eliceiri BP,Levin EG

    更新日期:2009-05-08 00:00:00

  • Systemic identification of estrogen-regulated genes in breast cancer cells through cap analysis of gene expression mapping.

    abstract::To explore the estrogen-regulated genes genome-widely in breast cancer, cap analysis of gene expression (CAGE) sequencing was performed in MCF-7 cells under estrogen treatment. Estrogen-regulated expressional changes were found in 1537 CAGE tag clusters (TCs) (⩾1.5 or ⩽0.66-folds). Among them, 15 TCs were situated in ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2014.04.033

    authors: Yamaga R,Ikeda K,Boele J,Horie-Inoue K,Takayama K,Urano T,Kaida K,Carninci P,Kawai J,Hayashizaki Y,Ouchi Y,de Hoon M,Inoue S

    更新日期:2014-05-09 00:00:00

  • Anti-angiogenesis effect of trichosanthin and the underlying mechanism.

    abstract::The growth and metastasis of tumors depend on angiogenesis. Tumor angiogenesis is initiated by the secretion of growth factors from tumor cells; downstream signals are then triggered in pre-existing blood vessels to sprout a new vascular network. Trichosanthin (TCS) is a type I ribosome-inactivating protein that has a...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2012.11.080

    authors: He D,Jin J,Zheng Y,Bruce IC,Tam S,Ma X

    更新日期:2013-01-11 00:00:00

  • Angiotensin II modulates ion transport in rat proximal tubules through CYP metabolites.

    abstract::To assess the effect of angiotensin II on ion transport in rat isolated proximal tubules and establish the arachidonic acid cytochrome P450 metabolites' role mediating angiotensin II effect and to analyze whether corticosteroids play a role modulating this effect, we studied the effect of low (10 and 100 pM) and high ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.2000.2807

    authors: Sánchez-Mendoza A,López-Sánchez P,Vázquez-Cruz B,Rios A,Martínez-Ayala S,Escalante B

    更新日期:2000-06-07 00:00:00

  • Calcium dependent inositol trisphosphate-induced calcium release in the guinea-pig taenia caeci.

    abstract::The properties of the Ca stores in the skinned fiber bundles of the guinea-pig taenia caeci were studied by a novel method to measure Ca released from the stores using a fluorescent Ca indicator, fura-2. It is found that the capacity of the Ca stores amounts some 170 mumoles/liter cell water. There are at least two Ca...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(87)90449-9

    authors: Iino M

    更新日期:1987-01-15 00:00:00

  • Regulatory role of GM3 ganglioside in integrin function, as evidenced by its effect on function of alpha 5 beta 1-liposomes: a preliminary note.

    abstract::Mouse mammary carcinoma mutant cell line FUA169, characterized by high GM3 ganglioside content, was established from parent cell line FM3A/F28-7, which has high LacCer content but no GM3. Although both cell lines showed the same quantity and quality of integrin receptors, FUA169 showed much stronger adhesion to fibron...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(05)81561-x

    authors: Zheng M,Tsuruoka T,Tsuji T,Hakomori S

    更新日期:1992-08-14 00:00:00

  • Thylakoid-bound chloroplast DNA from spinach is enriched for replication forks.

    abstract::Chloroplast DNA is bound to the thylakoids of spinach chloroplasts. To examine a possible role for thylakoid-bound DNA in chloroplast DNA replication, vesicles formed by treating chloroplasts in 3.5 mM MgCl2 were used. Chloroplast DNA fragments are bound to the surface of these vesicles. Chloroplast DNA isolated from ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(05)80194-9

    authors: Lindbeck AG,Rose RJ

    更新日期:1990-10-15 00:00:00

  • Isolation of an evolutionarily conserved epidermal growth factor receptor cDNA from human A431 carcinoma cells.

    abstract::Complementary DNA corresponding to total poly(A)+-RNA from the human A431 epidermoid carcinoma cell line was cloned in the phage expression vector lambda gt 11. An epidermal growth factor (EGF) receptor cDNA clone was obtained by screening of the expression library with a rabbit polyclonal antibody (IgG), raised to th...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(84)90926-4

    authors: Simmen FA,Gope ML,Schulz TZ,Wright DA,Carpenter G,O'Malley BW

    更新日期:1984-10-15 00:00:00

  • Long non-coding RNA linc00665 interacts with YB-1 and promotes angiogenesis in lung adenocarcinoma.

    abstract::Angiogenesis is a core hallmark of advanced cancers, especially in lung adenocarcinoma (LUAD). However, the underlying functions and mechanisms of lncRNAs in tumor angiogenesis remain largely unknown. Here we found that linc00665 depletion could markedly depressed proliferation and capillary tube formation of HUVECs i...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2020.04.108

    authors: Cong Z,Diao Y,Li X,Jiang Z,Xu Y,Zhou H,Qiang Y,Wu H,Shen Y

    更新日期:2020-06-25 00:00:00

  • Reversal of new-onset type 1 diabetes in mice by syngeneic bone marrow transplantation.

    abstract::Autologous hematopoietic stem cell transplantation (HSCT) has recently been performed as a novel strategy to treat patients with new-onset type 1 diabetes (T1D). However, the mechanism of autologous HSCT-induced remission of diabetes remains unknown. In order to help clarify the mechanism of remission-induction follow...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2008.07.016

    authors: Wen Y,Ouyang J,Yang R,Chen J,Liu Y,Zhou X,Burt RK

    更新日期:2008-09-19 00:00:00

  • LncRNA TP73-AS1 predicts the prognosis of bladder cancer patients and functions as a suppressor for bladder cancer by EMT pathway.

    abstract::Long noncoding RNAs (lncRNAs) have been identified to have more and more important roles in tumorigenesis and may be novel biomarker for cancer therapy. LncRNA TP73-AS1 is a novel identified lncRNA that has been demonstrated to be increased in several cancers, however, its function in bladder cancer remains unknown. T...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2018.04.010

    authors: Tuo Z,Zhang J,Xue W

    更新日期:2018-05-23 00:00:00

  • Chinese hamster ovary cells resistant to okadaic acid express a multidrug resistant phenotype.

    abstract::Two Chinese hamster ovary cell clones resistant to okadaic acid (OA) were isolated. The OA-resistance was associated with resistance to colchicine, Vinca alkaloids and inhibitors of DNA topoisomerase (topo) II. Drug accumulation assays showed that the intracellular levels of OA, vinblastine and vincristine, but not th...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1994.2311

    authors: Tohda H,Yasui A,Yasumoto T,Nakayasu M,Shima H,Nagao M,Sugimura T

    更新日期:1994-09-15 00:00:00

  • Isolation of fatty acids covalently bound to the gastric mucus glycoprotein of normal and cystic fibrosis patients.

    abstract::Covalently bound fatty acids were found in strictly purified and delipidated gastric mucus glycoprotein of normal and cystic fibrosis individuals. The susceptibility of this linkage to methanolic KOH and hydroxylamine treatment indicated the ester bond between fatty acids and glycoprotein. On the average, 2.9 nmol fat...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(83)90464-3

    authors: Slomiany A,Slomiany BL,Witas H,Aono M,Newman LJ

    更新日期:1983-05-31 00:00:00

  • Quantum dots in bio-imaging: Revolution by the small.

    abstract::Visual analysis of biomolecules is an integral avenue of basic and applied biological research. It has been widely carried out by tagging of nucleotides and proteins with traditional fluorophores that are limited in their application by features such as photobleaching, spectral overlaps, and operational difficulties. ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbrc.2005.02.043

    authors: Arya H,Kaul Z,Wadhwa R,Taira K,Hirano T,Kaul SC

    更新日期:2005-04-22 00:00:00

  • Induction of the ethanol-inducible form of rabbit liver microsomal cytochrome P-450 by inhibitors of alcohol dehydrogenase.

    abstract::Cytochrome P-450 LMeb was purified from liver microsomes obtained from rabbits treated with either benzene or imidazole and was shown to have identical N-terminal amino acid sequence as that of cytochrome P-450 LM3a. The amino acid compositions of the proteins were indistinguishable. Quantitation of P-450 LMeb in vari...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(84)91563-8

    authors: Ingelman-Sundberg M,Jörnvall H

    更新日期:1984-10-30 00:00:00

  • Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability.

    abstract::As an important factor leading to aging and chronic diseases, oxidative stress has become a hot research topic. Trehalose is a natural sugar widely found in many edible plants, animals and natural microorganisms, and recent studies have suggested that trehalose is an antioxidant, although its underlying molecular mech...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2019.10.088

    authors: Sun L,Zhao Q,Xiao Y,Liu X,Li Y,Zhang J,Pan J,Zhang Z

    更新日期:2020-01-01 00:00:00

  • Construction of nerve guide conduits from cellulose/soy protein composite membranes combined with Schwann cells and pyrroloquinoline quinone for the repair of peripheral nerve defect.

    abstract::Regeneration and functional reconstruction of peripheral nerve defects remained a significant clinical challenge. Nerve guide conduits, with seed cells or neurotrophic factors (NTFs), had been widely used to improve the repair and regeneration of injured peripheral nerve. Pyrroloquinoline quinone (PQQ) was an antioxid...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2014.12.121

    authors: Luo L,Gan L,Liu Y,Tian W,Tong Z,Wang X,Huselstein C,Chen Y

    更新日期:2015-02-20 00:00:00

  • Acidic stimulation induces a negative regulatory factor that affects alternative exon selection in vitro in human ATP synthase gamma-subunit pre-mRNA.

    abstract::Tissue-specific alternative RNA splicing in human F1gamma pre-mRNA produces muscle- and nonmuscle-type isoforms. Muscle-specific exclusion of exon 9 of the F1gamma gene is cell-specifically induced by acidic treatment of human fibrosarcoma HT1080 and rhabdomyosarcoma KYM-1 cells. We constructed an F1gamma minigene con...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1998.9525

    authors: Hayakawa M,Endo H,Hamamoto T,Kagawa Y

    更新日期:1998-10-20 00:00:00

  • Comparison between α-synuclein wild-type and A53T mutation in a progressive Parkinson's disease model.

    abstract:BACKGROUND AND AIMS:Vector based over-expression of α-synuclein is a newly developed method to establish animal Parkinson's disease (PD) model. In this paper, we inject the rat brain with recombinant adeno-associated virus (rAAV) to express α-synuclein wild-type and A53T mutation, and compared the degeneration of dopam...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2015.07.007

    authors: Lu J,Sun F,Ma H,Qing H,Deng Y

    更新日期:2015-09-04 00:00:00

  • Dasatinib, a second-generation tyrosine kinase inhibitor, induces melanogenesis via ERK-CREB-MITF-tyrosinase signaling in normal human melanocytes.

    abstract::Dasatinib, a second-generation tyrosine kinase inhibitor, is indicated for the therapy of imatinib-resistant leukemia and also for the treatment of solid cancers. Here, we report a novel effect of dasatinib of inducing differentiation in normal human melanocytes. Treatment with dasatinib significantly increased the me...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2020.01.051

    authors: Kang B,Kim Y,Park TJ,Kang HY

    更新日期:2020-03-19 00:00:00

  • Proteinase activity in the white shrimp (Penaeus vannamei) clotting protein.

    abstract::The clottable protein (CP) was isolated from white shrimp, Penaeus vannamei plasma as a 400-kDa protein that splits to two identical 200-kDa subunits when it is reduced with 2-ME. However, using DTT as reducing agent, four main bands were observed; two of them (179 and 125 kDa) had the same N-terminus sequence of the ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.2001.5595

    authors: Reyes-Izquierdo T,Vargas-Albores F

    更新日期:2001-09-21 00:00:00

  • Glutathione disulfide enhances the reduced glutathione inhibition of lipid peroxidation in rat liver microsomes.

    abstract::Experiments were undertaken to examine the effects of reduced (GSH) and oxidized (GSSG) glutathione on lipid peroxidation of rat liver microsomes. Dependence on microsomal alpha-tocopherol was shown for the GSH inhibition of lipid peroxidation. However, when GSH (5 mM) and GSSG (2.5 mM) were combined in the assay syst...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(90)90904-2

    authors: Scholz RW,Graham KS,Reddy CC

    更新日期:1990-01-30 00:00:00

  • miR-137 inhibits glutamine catabolism and growth of malignant melanoma by targeting glutaminase.

    abstract::Glutamine catabolism is considered to be an important metabolic pathway for cancer cells. Glutaminase (GLS) is the important rate-limiting enzyme of glutamine catabolism. miR-137 functions as a tumor suppressor in many human malignant tumors. However, the role and molecular mechanism of miR-137 and GLS in malignant me...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2017.10.152

    authors: Luan W,Zhou Z,Zhu Y,Xia Y,Wang J,Xu B

    更新日期:2018-01-01 00:00:00

  • FoxA1 as a lineage-specific oncogene in luminal type breast cancer.

    abstract::The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast can...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2007.11.064

    authors: Yamaguchi N,Ito E,Azuma S,Honma R,Yanagisawa Y,Nishikawa A,Kawamura M,Imai J,Tatsuta K,Inoue J,Semba K,Watanabe S

    更新日期:2008-01-25 00:00:00

  • Isocitrate dehydrogenase 2 deficiency induces endothelial inflammation via p66sh-mediated mitochondrial oxidative stress.

    abstract::Isocitrate dehydrogenase 2 (IDH2) is an essential enzyme in the mitochondrial antioxidant system, which produces nicotinamide adenine dinucleotide phosphate, and thereby defends against oxidative stress. We have shown that IDH2 downregulation results in mitochondrial dysfunction and reactive oxygen species (ROS) gener...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2018.07.117

    authors: Choi SJ,Piao S,Nagar H,Jung SB,Kim S,Lee I,Kim SM,Song HJ,Shin N,Kim DW,Irani K,Jeon BH,Park JW,Kim CS

    更新日期:2018-09-10 00:00:00

  • Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts.

    abstract::To explore the mechanism of glucocorticoid-induced osteoporosis, we investigated the effect of glucocorticoid on canonical Wnt signaling that emerged as a novel key pathway for promoting bone formation. Wnt3a increased the T-cell factor (Tcf)/lymphoid enhancer factor (Lef)-dependent transcriptional activity in primary...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2005.01.117

    authors: Ohnaka K,Tanabe M,Kawate H,Nawata H,Takayanagi R

    更新日期:2005-04-01 00:00:00

  • Cyclic stretch induces upregulation of endothelin-1 with keratinocytes in vitro: possible role in mechanical stress-induced hyperpigmentation.

    abstract::The aim of this study was to investigate the possible pathological relation between mechanical stress and hyperpigmentation. We did this by investigating the influence of cyclic stretch on the expression of keratinocyte- and fibroblast-derived melanogenetic paracrine cytokines in vitro. Using primary human keratinocyt...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2011.04.118

    authors: Kurita M,Okazaki M,Fujino T,Takushima A,Harii K

    更新日期:2011-05-27 00:00:00

  • Hemozoin formation in malaria: a two-step process involving histidine-rich proteins and lipids.

    abstract::Major blood stage antimalarial drugs like chloroquine and artemisinin target the heme detoxification process of the malaria parasite. Hemozoin formation reactions in vitro using the Plasmodium falciparum histidine-rich protein-2 (Pfhrp-2), lipids, and auto-catalysis are slow and could not explain the speed of detoxifi...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(03)01465-7

    authors: Pandey AV,Babbarwal VK,Okoyeh JN,Joshi RM,Puri SK,Singh RL,Chauhan VS

    更新日期:2003-09-05 00:00:00

  • Ubiquitination of specific mitochondrial matrix proteins.

    abstract::Several protein quality control systems in bacteria and/or mitochondrial matrix from lower eukaryotes are absent in higher eukaryotes. These are transfer-messenger RNA (tmRNA), The N-end rule ATP-dependent protease ClpAP, and two more ATP-dependent proteases, HslUV and ClpXP (in yeast). The lost proteases resemble the...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2016.04.150

    authors: Lehmann G,Ziv T,Braten O,Admon A,Udasin RG,Ciechanover A

    更新日期:2016-06-17 00:00:00

  • Expression of HIV-1 envelope glycoprotein alters cellular calmodulin.

    abstract::Removal of parts of a known calmodulin binding site at the C-terminus of HIV-1 envelope glycoprotein, gp160, can result in diminished infectivity. We investigated whether expression of full length gp160 would result in changes in intracellular calmodulin compared to expression of gp160 truncated to remove both known c...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1996.0034

    authors: Radding W,Pan ZQ,Hunter E,Johnston P,Williams JP,McDonald JM

    更新日期:1996-01-05 00:00:00