Abstract:
:The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted alpha-helix-turn-alpha-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3' untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Uchida K,Morita T,Sato T,Ogura T,Yamashita R,Noguchi S,Suzuki H,Nyunoya H,Miwa M,Sugimura Tdoi
10.1016/0006-291x(87)90921-1subject
Has Abstractpub_date
1987-10-29 00:00:00pages
617-22issue
2eissn
0006-291Xissn
1090-2104pii
0006-291X(87)90921-1journal_volume
148pub_type
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