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Differential regulation of multiple neuroreceptors in a somatic cell hybrid by inhibitors of glycoprotein processing.

Abstract：

:Specific binding of [3H][D-Ala2,D-Leu5]enkephalin, [3H]ethylketocyclazocine, 5-[3H]hydroxytryptamine, and [3H]spiperone was examined in neuroblastoma-brain hybrid cell line NCB-20 following exposure to inhibitors of N-linked protein glycosylation (tunicamycin, TM) and oligosaccharide processing (swainsonine, SW). TM treatment reduced ligand binding at delta- and sigma-opiate receptors and neuroleptic binding sites (20 to 50% of control), with no discernible effect on the binding properties of 5HT1-serotonin receptors. In contrast, exposure to SW resulted in a three-fold increase in binding capacity of sigma-receptors, while decreasing receptor affinity for ligand. SW treatment did not alter ligand interactions with either sigma-receptors or neuroleptic binding sites, but did reduce specific binding of serotonin to 5HT1-receptors. The effects of TM and SW on distinct receptor subpopulations were further demonstrated by attenuation of opiate and serotonin-mediated regulation of intracellular cyclic AMP.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

McLawhon RW,Berry-Kravis E,Dawson G

doi

10.1016/0006-291x(86)90403-1

subject

Has Abstract

pub_date

1986-02-13 00:00:00

pages

1387-94

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(86)90403-1

journal_volume

134

pub_type

杂志文章

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