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Evidence for a direct role of the DNA polymerase gamma in the replication of the human mitochondrial DNA in vitro.

Abstract：

:Indirect experiments suggest that DNA polymerase gamma is involved in the mitochondrial DNA replication process. This report describes an in vitro mitochondrial DNA replication assay directed by the origin of replication of the Heavy strand mt DNA. The assay requires all four dNTP, rNTP and an ATP regenerating system. Nuclease digestion experiments show that specific events occur at the mt origin of replication. Antibodies raised against the purified DNA polymerase gamma inhibit the DNA replication reaction.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lestienne P

doi

10.1016/0006-291x(87)90767-4

subject

Has Abstract

pub_date

1987-08-14 00:00:00

pages

1146-53

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90767-4

journal_volume

146

pub_type

杂志文章

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