A pea chloroplast translation elongation factor that is regulated by abiotic factors.

abstract：:Angiogenesis plays a pivotal role in gastric ulcer repair. Several growth factors are involved in angiogenesis, and of these, vascular endothelial growth factor (VEGF) has received considerable attention, since it is the only factor that specifically acts on endothelial cells. However, the role of VEGF in gastric ulce...

journal_title：Biochemical and biophysical research communications

authors： Takahashi M,Kawabe T,Ogura K,Maeda S,Mikami Y,Kaneko N,Terano A,Omata M

更新日期：1997-05-19 00:00:00

abstract：:To isolate seizure-related genes, we applied differential screening technique to the cDNA library which constructed from primary cultured cerebral cortical cells treated with pentylenetetrazol (PTZ). Northern blotting analysis of mRNA levels in the cerebra after systemic administration of PTZ confirmed the results of ...

journal_title：Biochemical and biophysical research communications

authors： Kajiwara K,Nagawawa H,Shimizu-Nishikawa S,Ookuri T,Kimura M,Sugaya E

更新日期：1996-02-27 00:00:00

abstract：:C-type natriuretic peptide (CNP) which potently stimulates particulate guanylate cyclase activity in cultured rat vascular smooth muscle cells (VSMC) inhibited serum-induced DNA synthesis of the cells 10-fold more effectively than alpha-human atrial natriuretic peptide (alpha-hANP). The inhibitory effect of CNP was mi...

journal_title：Biochemical and biophysical research communications

authors： Furuya M,Yoshida M,Hayashi Y,Ohnuma N,Minamino N,Kangawa K,Matsuo H

更新日期：1991-06-28 00:00:00

abstract：:Regulation of the bone sialoprotein (BSP) gene is important in the differentiation of osteoblasts, in bone matrix mineralization, and in tumor metastasis. We investigated BSP gene transcription by performing functional analysis of the 9256bp of the 5' flanking region of the murine BSP gene containing its promoter. We ...

journal_title：Biochemical and biophysical research communications

authors： Tu Q,Yamauchi M,Pageau SC,Chen JJ

更新日期：2004-04-02 00:00:00

abstract：:Drosophila DLG (Discs Large Tumor Suppresser Protein) is a component of septate junctions, and disruption of its gene leads to over growth of imaginal discs. Homologs of Drosophila DLG recently isolated from mammalian tissue have been classified as members of the MAGUK (Membrane Associated GUanylate Kinase) superfamil...

journal_title：Biochemical and biophysical research communications

authors： Inagaki H,Maeda S,Lin KH,Shimizu N,Saito T

更新日期：1999-11-19 00:00:00

abstract：:Lipocalin-type prostaglandin D synthase (L-PGDS) is one of the most abundant proteins in human cerebrospinal fluid (CSF) with dual functions as a prostaglandin D2 (PGD2) synthase and a transporter of lipophilic ligands. Recent studies revealed that L-PGDS plays important roles in protecting against various neuronal di...

journal_title：Biochemical and biophysical research communications

authors： Qin S,Shimamoto S,Maruno T,Kobayashi Y,Kawahara K,Yoshida T,Ohkubo T

更新日期：2015-12-04 00:00:00

abstract：:Human prostasin was recently identified as a potential regulator of epithelial sodium channel (ENaC) function. Through the use of positional scanning combinatorial substrate libraries, prostasin was shown to have a preference for poly-basic substrates: in position P4 preference was for arginine or lysine; in P3 prefer...

journal_title：Biochemical and biophysical research communications

authors： Shipway A,Danahay H,Williams JA,Tully DC,Backes BJ,Harris JL

更新日期：2004-11-12 00:00:00

abstract：:We have determined the identity of the orphan G-protein coupled receptor cDNA, 6H1, present in activated chicken T cells, as a subtype of P2Y purinoceptor. This identification is based on first on the degree of sequence identity shared with recently cloned members of the P2Y receptor family and second on the pharmacol...

journal_title：Biochemical and biophysical research communications

authors： Webb TE,Kaplan MG,Barnard EA

更新日期：1996-02-06 00:00:00

abstract：:Adeno-associated virus (AAV) capsids are composed of three proteins, VP1, VP2, and VP3. These capsid proteins have a common amino acid sequence, being expressed from different initiation codons on the same open reading frame. Although VP1 is necessary for viral infection, it is not essential for capsid formation. The ...

journal_title：Biochemical and biophysical research communications

authors： Hoque M,Shimizu N,Ishizu Ki,Yajima H,Arisaka F,Suzuki K,Watanabe H,Handa H

更新日期：1999-12-20 00:00:00

abstract：:Negative regulator of differentiation 1 (Nrd1) is known as a negative regulator of sexual differentiation in fission yeast. Recently, it has been revealed that Nrd1 also regulates cytokinesis, in which physical separation of the cell is achieved by a contractile ring comprising many proteins including actin and myosin...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi A,Kanaba T,Satoh R,Fujiwara T,Ito Y,Sugiura R,Mishima M

更新日期：2013-07-19 00:00:00

abstract：:A gene encoding the human immunodeficiency virus-1 (HIV-1) TAT protein was chemically synthesized and expressed in HeLa cells and in a cell-free system. To facilitate both the assembly of the synthetic gene and further mutagenesis and gene fusion studies, several unique restriction endonuclease cleavage sites were inc...

journal_title：Biochemical and biophysical research communications

authors： Ferguson BQ,Friedland BK,Hendrickson E,Strehl L,Petteway SR,Jonak GJ

更新日期：1989-05-15 00:00:00

abstract：:Information about histone sequences and histone gene organization from invertebrate chordates is completely lacking. A genomic clone containing linked H3 and H4 histone genes from the urochordate Styela plicata was analyzed. The nucleotide sequence indicates that the two genes are transcribed in opposite directions an...

journal_title：Biochemical and biophysical research communications

authors： Ishaq AI,Rizvi SB,Wells DE,Tomlinson CR

更新日期：1993-07-30 00:00:00

abstract：:Model-free approaches (error-prone PCR to introduce random mutations, DNA shuffling to combine positive mutations, and screening of the resultant mutant libraries) have been used to enhance the catalytic activity and thermostability of alpha-aspartyl dipeptidase from Salmonella typhimurium, which is uniquely able to h...

journal_title：Biochemical and biophysical research communications

authors： Kong X,Liu Y,Gou X,Zhu S,Zhang H,Wang X,Zhang J

更新日期：2001-11-23 00:00:00

abstract：:Synthesis of ABCA1 protein in liver is necessary for high-density lipoproteins (HDL) formation in mammals. Nuclear receptor PPARγ is known as activator of ABCA1 expression, but details of PPARγ-mediated regulation of ABCA1 at both transcriptional and post-transcriptional levels in hepatocytes have not still been well ...

journal_title：Biochemical and biophysical research communications

authors： Mogilenko DA,Shavva VS,Dizhe EB,Orlov SV,Perevozchikov AP

更新日期：2010-11-19 00:00:00

abstract：:The syndrome of generalized epilepsy with febrile seizures plus type 1 (GEFS+) has been associated to the gene SCN1B coding for the sodium channel beta1 subunit (Wallace, R. H. et al. (1998) Nature Genetics 19, 366-370). In patients, a mutation of the cysteine 121 to trpyptophane (C121W) would cause a lack of modulato...

journal_title：Biochemical and biophysical research communications

authors： Moran O,Conti F

更新日期：2001-03-23 00:00:00

abstract：:Phosphoinositide phospholipase C (PLC) was extracted from the synaptic membrane fraction of rat brain by 1% sodium deoxycholate. The molecular weight and sedimentation coefficient of the membrane PLC were about 160,000 and 6.7 as estimated by gel filtration and sucrose density gradient centrifugation, respectively. Th...

journal_title：Biochemical and biophysical research communications

authors： Kozawa O,Hoshijima M,Tanimoto T,Ohmori T,Takai Y

更新日期：1987-05-29 00:00:00

abstract：:We have analyzed the cellular effects of nanosecond pulsed electrical fields on plant cells using fluorescently tagged marker lines in the tobacco cell line BY-2 and confocal laser scanning microscopy. We observe a disintegration of the cytoskeleton in the cell cortex, followed by contraction of actin filaments toward...

journal_title：Biochemical and biophysical research communications

authors： Berghöfer T,Eing C,Flickinger B,Hohenberger P,Wegner LH,Frey W,Nick P

更新日期：2009-09-25 00:00:00

abstract：:Catabolite inactivation of fructose 1,6-bisphosphatase and cytoplasmic malate dehydrogenase was studied using the protease-deficient and vacuole-defective yeast strain pep4-3. The catabolite inactivation of fructose 1,6-bisphosphatase in pep4-3 was found to have a normal first inactivation step but with a defective se...

journal_title：Biochemical and biophysical research communications

authors： Funaguma T,Toyoda Y,Sy J

更新日期：1985-07-16 00:00:00

abstract：:We have investigated the effects of three unrelated topoisomerase 2 inhibitors, genistein, adriamycin, and etoposide, on phosphorylation/activation of the checkpoint kinase Chk2 in normal or ATM-deficient (ATM-) human fibroblasts and in cells overexpressing a catalytically inactive ATR kinase. We demonstrate that geni...

journal_title：Biochemical and biophysical research communications

authors： Théard D,Coisy M,Ducommun B,Concannon P,Darbon JM

更新日期：2001-12-21 00:00:00

abstract：:We previously reported that the suppression of SIRT2, an NAD + -dependent protein deacetylases, induces p53 accumulation via degradation of p300 and the subsequent MDM2 degradation, eventually leading to apoptosis in HeLa cells. The present study identified a novel pathway of p53 accumulation by SIRT2 suppression in H...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Kokura K,Inoue T

更新日期：2019-01-01 00:00:00

abstract：:We report high resolution images of RecA-double stranded (ds) DNA complexes obtained by atomic force microscopy (AFM). When a carbon nanotube (CNT) tip was used, AFM images visualized the 10-nm pitch of RecA-dsDNA complexes and RecA filaments as three-dimensional surface topography without reconstruction analysis. The...

journal_title：Biochemical and biophysical research communications

authors： Umemura K,Komatsu J,Uchihashi T,Choi N,Ikawa S,Nishinaka T,Shibata T,Nakayama Y,Katsura S,Mizuno A,Tokumoto H,Ishikawa M,Kuroda R

更新日期：2001-02-23 00:00:00

abstract：:Multidrug resistance (MDR) in mammalian tumors or tissues is often associated with the overexpression of the putative drug efflux pump P-glycoprotein (Pgp). One theory concerning the mechanism of Pgp activity is that efflux of ATP is coupled to drug efflux. Evidence in support of this theory has been observed in mamma...

journal_title：Biochemical and biophysical research communications

authors： Boyum R,Guidotti G

更新日期：1997-01-03 00:00:00

abstract：:The interaction between the receptor (Rc) for atrial natriuretic peptide (ANP) and the effector enzyme particulate guanylate cyclase (GC) has been studied by radiation inactivation. Irradiation of bovine lung membranes produced an increase in GC activity at low radiation doses followed by a dose-dependent reduction at...

journal_title：Biochemical and biophysical research communications

authors： Ohuchi S,Hagiwara H,Ishido M,Fujita T,Kume T,Ishigaki I,Hirose S

更新日期：1989-01-31 00:00:00

abstract：:Custom-designed zinc finger nucleases (ZFNs) are becoming powerful tools in gene targeting-the process of replacing a gene within a genome by homologous recombination. Here, we have studied the DNA cleavage by one such ZFN, DeltaQNK-FN, in order to gain insight into how ZFNs cleave DNA and how two inverted sites promo...

journal_title：Biochemical and biophysical research communications

authors： Mani M,Smith J,Kandavelou K,Berg JM,Chandrasegaran S

更新日期：2005-09-09 00:00:00

abstract：:A mitosis inhibiting peptide pyroGlu-Glu-Asp-Ser-GlyOH has been isolated from mouse skin extracts. Both the biological and a synthetic peptide with the same structure reversibly inhibit epidermal mitoses in a curvilinear fashion after intraperitoneal injection. The two compounds are chromatographically identical. ...

journal_title：Biochemical and biophysical research communications

authors： Reichelt KL,Elgjo K,Edminson PD

更新日期：1987-08-14 00:00:00

abstract：:NOS activity has been recently described in airway epithelial cells. Because these cells are often ciliated we hypothesized that NO modulates airway ciliary beating. CBF was measured in cultured BBECs using video microscopy. L-NMMA, a NOS inhibitor, caused a 40% decrease in CBF following pre-stimulation with isoproter...

journal_title：Biochemical and biophysical research communications

authors： Jain B,Rubinstein I,Robbins RA,Leise KL,Sisson JH

更新日期：1993-02-26 00:00:00

abstract：:RING finger (C3HC4-type zinc finger) is a variant zinc finger motif present in a large family of functionally distinct proteins. We describe the cloning and characterization of a novel human transcript RNF38 encoding a new member of the RING finger protein family. The complete mRNA consists of about 6.8 kb widely expr...

journal_title：Biochemical and biophysical research communications

authors： Eisenberg I,Hochner H,Levi T,Yelin R,Kahan T,Mitrani-Rosenbaum S

更新日期：2002-06-28 00:00:00

abstract：:Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1) modulates phospho-signaling by catalyzing rotation of the bond between a phosphorylated serine or threonine before proline in proteins. As depletion of PIN1 increased inflammatory protein expression in cultured endothelial cells treated with bacterial endot...

journal_title：Biochemical and biophysical research communications

authors： Liu T,Schneider RA,Lee NY,Hoyt DG

更新日期：2014-09-26 00:00:00

abstract：:We have developed a continuous fluorescence assay based on fluorescence resonance energy transfer (FRET) for the monitoring of RNA helicase activity in vitro. The assay is tested using the hepatitis C virus (HCV) NS3 helicase as a model. We prepared a double-stranded RNA (dsRNA) substrate with a 5' fluorophore-labeled...

journal_title：Biochemical and biophysical research communications

authors： Tani H,Fujita O,Furuta A,Matsuda Y,Miyata R,Akimitsu N,Tanaka J,Tsuneda S,Sekiguchi Y,Noda N

更新日期：2010-02-26 00:00:00

abstract：:Inhibitors of serine/threonine protein phosphatases can inhibit apoptosis. We investigated which protein phosphatases are critical for this protection using calyculin A, okadaic acid, and tautomycin. All three phosphatase inhibitors prevented anisomycin-induced apoptosis in leukemia cell models. In vitro, calyculin A ...

journal_title：Biochemical and biophysical research communications

authors： Chatfield K,Eastman A

更新日期：2004-10-29 00:00:00