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Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a "redox cycling" mechanism in MPTP neurotoxicity.

Abstract：

:The ability of paraquat, MPP+, and analogs to be reduced by chemical reductants and by NADPH, as catalyzed by liver microsomes or purified NADPH cytochrome P-450 reductase, is reported. The analogs span a range of electrochemical potential, including values in-between that of paraquat and MPP+. Analogs with an Eo below -.55 V (vs. NHE) are not reduced by either the NADPH-microsomes or NADPH-reductase systems. The inability of MPP+ to be bio-reduced or to stimulate the production of superoxide during aerobic reduction is evidence against a redox-cycling (oxidant stress) role of MPP+ in MPTP neurotoxicity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Frank DM,Arora PK,Blumer JL,Sayre LM

doi

10.1016/s0006-291x(87)80183-3

subject

Has Abstract

pub_date

1987-09-30 00:00:00

pages

1095-104

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(87)80183-3

journal_volume

147

pub_type

杂志文章

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