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Receptor-mediated regulation of calcium mobilization and cyclic GMP synthesis in neuroblastoma cells.

Abstract：

:In neuroblastoma N1E 115 cells, carbachol, histamine and PGE1 elevated cyclic GMP content and, induced the efflux of preloaded 45Ca2+, the release of membrane-bound Ca2+ measured by fluorescent CTC, and the increase in [Ca2+]i as measured by Quin 2 fluorescence. The time course of the responses, the absolute requirement of extracellular Ca2+, the inhibition by receptor blockers, and the concentration dependency on histamine were all similar between these responses. The observation indicates that the mobilization of Ca2+, especially the increase of [Ca2+]i, may be intimately linked to the synthesis of cyclic GMP in the cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ohsako S,Deguchi T

doi

10.1016/0006-291x(84)90479-0

subject

Has Abstract

pub_date

1984-07-18 00:00:00

pages

333-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(84)90479-0

journal_volume

122

pub_type

杂志文章

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