当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type 1 diabetes.

TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type 1 diabetes.

Abstract：

:We investigated the role of Toll-like receptor 4 (TLR4), a major mediator of innate immune responses, on cognitive performance in a type 1 diabetes model (T1D). After administration of streptozotocin, both TLR4 knockout (TLR4 KO) and wild type (WT) diabetic mice displayed metabolic alterations similar to those observed in T1D patients, including increased levels of glucose, cholesterol, triglycerides and ketones. T1D mice exhibited cognitive impairment which was less severe in TLR4 KO mice compared to WT mice. WT mice with higher glucose and those with higher triglyceride levels exhibited significantly more anxiety and impaired memory compared to those with lower levels of glucose and triglycerides; these correlations were absent in TLR4 KO mice. Additional findings suggest roles for TLR4 signaling in modifying the expression of enzymes involved in energy metabolism in brain cells in the setting of T1D. Our data show that TLR4 contributes to the negative impact of T1D on anxiety and cognition.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kawamoto EM,Cutler RG,Rothman SM,Mattson MP,Camandola S

doi

10.1016/j.bbrc.2013.12.039

subject

Has Abstract

pub_date

2014-01-10 00:00:00

pages

731-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(13)02098-6

journal_volume

443

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2.

    abstract：:The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (Mpro) and the RNA-dependent RNA poly...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.10.091

    authors： Jin Z,Wang H,Duan Y,Yang H

    更新日期：2020-11-21 00:00:00

  • Identification of cyclic AMP response element in the human renin gene.

    abstract：:In order to identify the mechanism by which cyclic AMP stimulates expression of the human renin gene (REN), the effect of forskolin was tested in transient expression analyses of REN 5'-flanking DNA-chloramphenicol acetyltransferase (CAT) reporter gene constructs in secondary cultures of human chorio-decidual cells, a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.1451

    authors： Smith DL,Morris BJ,Do YS,Law RE,Shaw KJ,Hseuh WA

    更新日期：1994-04-15 00:00:00

  • The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signals.

    abstract：:Fructosamine-3-kinase (FN3K) and the more recently discovered fructosamine-3-kinase related protein (FN3KRP) appear to protect proteins from nonenzymatic glycation. To elucidate the patterns of transcriptional regulation of these two genes, we performed in silico comparisons of their promoters along with real-time PCR...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.08.181

    authors： Conner JR,Beisswenger PJ,Szwergold BS

    更新日期：2004-10-22 00:00:00

  • Lysis of trypanosomes by peptidyl fluoromethyl ketones.

    abstract：:Peptidyl fluoromethyl ketones, improved reagents for inactivating cysteinyl and serine proteinases, have provided unexpected results when applied to intact trypanosomes. A lethal effect was observed but limited to the infectious phase of the parasitic growth cycle. Since the inhibitors are known only to act on proteas...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)92179-4

    authors： Ashall F,Angliker H,Shaw E

    更新日期：1990-07-31 00:00:00

  • Effects of leptin gene expression in mice in vivo by electroporation and hydrodynamics-based gene delivery.

    abstract：:In vivo electroporation and hydrodynamics-based gene delivery were utilized to test the effect of leptin gene transfer on food intake, and body and fat weights of mice. Gene transfer of pVRmob by electroporation caused a significant reduction in body weight compared with the control counterpart (p<0.05), although a le...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01172-0

    authors： Xiang L,Murai A,Sugahara K,Yasui A,Muramatsu T

    更新日期：2003-08-01 00:00:00

  • Bifunctional DNA-gold nanoparticle conjugates as building blocks for the self-assembly of cross-linked particle layers.

    abstract：:The DNA-directed self-assembly of surface-bound layers of gold nanoparticles offers a broad range of applications in biomedical analyses as well as in materials science. We here describe a new concept for the assembly of substrate-bound nanoparticle monolayers which employs bifunctional nanoparticles as building block...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.10.103

    authors： Niemeyer CM,Ceyhan B,Noyong M,Simon U

    更新日期：2003-11-28 00:00:00

  • Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis.

    abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane cytokine and a potent inducer of apoptosis. Epidermal growth factor (EGF) signaling is well known to involve in tumor survival and overexpression of EGF receptor (EGF-R) attributes to decreased responsiveness to many avail...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)00719-2

    authors： Park SY,Seol DW

    更新日期：2002-07-12 00:00:00

  • Heat shock induces phosphorylation of histone H2AX in mammalian cells.

    abstract：:Heat shock induces a variety of biological events including gene activation, cell cycle arrest, and apoptosis. Heat shock has recently been shown to be potentially useful when combined with radiation in cancer therapy, probably because, in mammalian cells, heat inhibits the repair of double-strand breaks (DSBs) induce...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.01.073

    authors： Kaneko H,Igarashi K,Kataoka K,Miura M

    更新日期：2005-03-25 00:00:00

  • ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin.

    abstract：:Human AlkB homolog 8 (ALKBH8) is highly expressed in high-grade, superficially and deeply invasive bladder cancer. Moreover, ALKBH8 knockdown induces apoptosis in bladder cancer cells. However, the underlying anti-apoptotic mechanism of ALKBH8 in bladder cancer cells has thus far remained unclear. Moreover, there is n...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.06.084

    authors： Ohshio I,Kawakami R,Tsukada Y,Nakajima K,Kitae K,Shimanoe T,Saigo Y,Hase H,Ueda Y,Jingushi K,Tsujikawa K

    更新日期：2016-08-26 00:00:00

  • A new method for rapid assignment of S-S bridges in proteins.

    abstract：:A new method for complementing existing protein chemical techniques for the assignment of S-S bridge positions in amino-acid sequences is described. The principle of the method is the direct examination of the masses of protein fragments, obtained by chemical or enzymatic degradation. Proteins are digested under condi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90302-x

    authors： Morris HR,Pucci P

    更新日期：1985-02-15 00:00:00

  • Attenuation of TGF-beta-induced apoptosis in primary cultures of hepatocytes by calpain inhibitors.

    abstract：:Apoptosis induced in primary cultures of rat hepatocytes by transforming growth factor beta 1 (TGF-beta 1) was greatly attenuated by inhibitors (5 microM) of calpain I and calpain II, respectively. Both inhibitors prevented the TGF-beta-elicited increase of nucleosomal DNA fragments and the occurrence of DNA-breaks in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.5777

    authors： Gressner AM,Lahme B,Roth S

    更新日期：1997-02-13 00:00:00

  • Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome.

    abstract：:Arctigenin (ARC), a phenylpropanoid dibenzylbutyrolactone lignan derived from Arctium lappa L, has been reported to protect against cerebral ischemia injury in rats, but the underlying mechanism is unclear. In this study, we investigated whether ARC ameliorated ischemic stroke by inhibiting NLRP3 inflammasome-derived ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.08.062

    authors： Zhang S,Jiang L,Che F,Lu Y,Xie Z,Wang H

    更新日期：2017-11-04 00:00:00

  • Purification and NH2-terminal sequence of cytochrome P-450 from kidney microsomes of untreated male rats.

    abstract：:The major form of cytochrome P-450, P-450K-5, was purified from kidney microsomes of untreated male rats with high-performance liquid chromatography with anion-exchange and hydroxylapatite columns. The monomeric molecular weight of P-450K-5 was 52000 on SDS-polyacrylamide gel electrophoresis and the CO-reduced absorpt...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80230-3

    authors： Imaoka S,Funae Y

    更新日期：1986-12-15 00:00:00

  • Stoichiometric carboxyl methylation of chromogranins from bovine adrenal medullary cells.

    abstract：:The secretory proteins from adrenal chromaffin granules, chromogranins A, A1 and A2, were found to be excellent in vitro methyl acceptor proteins. The purified protein-carboxyl methylase (PCM) from bovine erythrocytes incorporated 660, 2540 and 7890 pmol of methyl group/10 min/mg protein in chromogranins A, A1 and A2,...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80099-8

    authors： Veeraragavan K,Coulombe R,Gagnon C

    更新日期：1988-04-29 00:00:00

  • The influence of Pyk2 on the mechanical properties in fibroblasts.

    abstract：:The cell surface receptor integrin is involved in signaling mechanical stresses via the focal adhesion complex (FAC) into the cell. Within FAC, the focal adhesion kinase (FAK) and Pyk2 are believed to act as important scaffolding proteins. Based on the knowledge that many signal transducing molecules are transiently i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.02.059

    authors： Klemm AH,Kienle S,Rheinlaender J,Schäffer TE,Goldmann WH

    更新日期：2010-03-19 00:00:00

  • Capsaicin stimulates glucose uptake in C2C12 muscle cells via the reactive oxygen species (ROS)/AMPK/p38 MAPK pathway.

    abstract：:Capsaicin has been reported to regulate blood glucose levels and to ameliorate insulin resistance in obese mice. This study demonstrates that capsaicin increases glucose uptake directly by activating AMP-activated protein kinase (AMPK) in C2C12 muscle cells, which manifested as an attenuation of glucose uptake when co...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.08.027

    authors： Kim SH,Hwang JT,Park HS,Kwon DY,Kim MS

    更新日期：2013-09-13 00:00:00

  • nonG, a constituent of the nonactin biosynthetic gene cluster, regulates nocardamine synthesis in Streptomyces albus J1074.

    abstract：:Many factors regulate the expression of specialised secondary metabolite biosynthetic gene clusters, which have been recognised as important for the discovery of novel microbial natural products. A cosmid library based on genomic DNA of the marine-derived Streptomyces puniceus Act1085 was constructed and screened to i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.06.098

    authors： Park W,Woo JK,Shin J,Oh KB

    更新日期：2017-08-26 00:00:00

  • Effect of human umbilical cord blood cells on glycemia and insulitis in type 1 diabetic mice.

    abstract：:Several studies have shown that transplantation of embryonic stem cells into diabetic animals either improved or normalized blood glucose levels. In this study, we examined the dose-dependent effect of early (prediabetic stage) intravenous administration of human umbilical cord blood (HUCB) mononuclear cells on blood ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.10.091

    authors： Ende N,Chen R,Reddi AS

    更新日期：2004-12-17 00:00:00

  • Extended analysis of AL-amyloid protein from abdominal wall subcutaneous fat biopsy: kappa IV immunoglobulin light chain.

    abstract：:In AL-amyloidosis the cause of amyloid fibril formation in beta-pleated sheets from the precursor protein immunoglobulin light chain is not established, but studies of AL-proteins indicate that amino acid substitutions are important in the pathogenesis. Amyloid material was extracted from a subcutaneous fat tissue bio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8515

    authors： Olsen KE,Sletten K,Westermark P

    更新日期：1998-04-28 00:00:00

  • In vitro-generated respiratory mucosa: a new tool to study inhalational anthrax.

    abstract：:We generated a three-dimensional (3-D) model of human airway tissues in order to study initiation of inhalational form of anthrax infection. The system was designed to model the air-blood barrier of the respiratory tract represented by epithelial cells and macrophages. When grown on collagen/fibronectin gel support at...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00830-1

    authors： Radyuk SN,Mericko PA,Popova TG,Grene E,Alibek K

    更新日期：2003-06-06 00:00:00

  • Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-kappaB.

    abstract：:Pancreatic elastase has been implicated in the pathophysiology of severe acute pancreatitis, characterized by systemic inflammatory response, distant organ failure, and high mortality. Here we show that pancreatic elastase activates transcription factors NF-kappaB, AP-1, and NFAT in human myeloid cells (U-937 and THP-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.08.077

    authors： Hietaranta A,Mustonen H,Puolakkainen P,Haapiainen R,Kemppainen E

    更新日期：2004-10-08 00:00:00

  • Direct radioimmunoassay for human atrial natriuretic peptide (hANP) and its clinical evaluation.

    abstract：:A direct radioimmunoassay for the rapid and accurate detection of human ANP from unextracted plasma is described. The sensitivity was approximately 50 pg/ml, respectively 2.5 pg/tube, the intra-assay variation 4%, and the inter-assay variation less than 12%. Rat ANP (1-28, 5-25, 5-27 and 5-28), oxydized and reduced hA...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80307-2

    authors： Jüppner H,Brabant G,Kapteina U,Kirschner M,Klein H,Hesch RD

    更新日期：1986-09-30 00:00:00

  • An ATP/2e-stoichiometry of 1 1/2 is thermodynamically possible for site 3 of oxidative phosphorylation.

    abstract：:Free energy changes for ATP synthesis (delta GP) and 2e(-)-transfer across Site 3 (delta GR) were determined during oxidative phosphorylation by rat liver mitochondria. At static head, -delta GR/delta GP ranged narrowly between 1.55 and 1.59 with five different respiratory substrates. Thus, an ATP/2e- of 1 1/2 at Site...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)90467-0

    authors： Lemasters JJ,Fleishman KE

    更新日期：1987-01-15 00:00:00

  • Effect of serine O-glycosylation on cis-trans proline isomerization.

    abstract：:In order to examine the ability of an O-glycosylated serine residue preceding proline to stabilize a cis amide conformation in a fashion similar to that observed with aromatic amino acid residues, we prepared a series of glycosylated analogs of a small linear peptide which we have previous reported to contain a cis co...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0198

    authors： Pao YL,Wormarld MR,Dwek RA,Lellouch AC

    更新日期：1996-02-06 00:00:00

  • The action of erythropoietin is mediated by lipoxygenase metabolites in murine fetal liver cells.

    abstract：:Erythroid progenitor cells synthesize 12-hydroxyeicosatetraenoic acid (12-HETE) and 15-hydroxyeicosatetraenoic acid (15-HETE) when stimulated by erythropoietin (Ep). Maximal stimulation of 12-HETE production occurred at one hour, whereas 15-HETE activity remained constant in response to Ep for 24 hours. Lipoxygenase-s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80134-1

    authors： Beckman BS,Mason-Garcia M,Nystuen L,King L,Fisher JW

    更新日期：1987-08-31 00:00:00

  • Crystal structure and biophysical characterisation of Helicobacter pylori phosphopantetheine adenylyltransferase.

    abstract：:Helicobacter pylori is a bacterium that causes chronic active gastritis and peptic ulcers. Drugs targeting H. pylori phosphopantetheine adenylyltransferase (HpPPAT), which is involved in CoA biosynthesis, may be useful. Herein, we report the expression in Escherichia coli and purification of recombinant HpPPAT and des...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.04.058

    authors： Cheng CS,Chen CH,Luo YC,Chen WT,Chang SY,Lyu PC,Kao MC,Yin HS

    更新日期：2011-05-06 00:00:00

  • Chloride-bicarbonate exchangers in the human fetal pancreas.

    abstract：:Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that encodes a small conductance cAMP-activated chloride ion channel. In the CF pancreatic duct, mutations in CFTR cause a reduction in bicarbonate secretion. This is thought to result from CFTR operating...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1367

    authors： Hyde K,Harrison D,Hollingsworth MA,Harris A

    更新日期：1999-09-24 00:00:00

  • Retinol-binding protein in human serum: conformational changes induced by retinoic acid binding.

    abstract：:Polyacrylamide gel electrophoresis and isoelectrofocusing followed by immunoblotting technique with an anti-human retinol-binding protein (RBP) serum were used to study holo-RBP and apo-RBP in human plasma. Three observations were made the technique allowed for the first time to directly and quantitatively analyse hol...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91370-2

    authors： Siegenthaler G,Saurat JH

    更新日期：1987-03-13 00:00:00

  • Microglial activation is a major contributor to neurologic dysfunction in thiamine deficiency.

    abstract：:In Wernicke's encephalopathy and thiamine deficiency (TD), the cause of this brain disorder, development of inflammation is an important aspect of the disease process. How this pathological mechanism relates to the neurologic impairment associated with TD, however, remains unclear. A key feature of the inflammatory pr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.09.128

    authors： Wang D,Hazell AS

    更新日期：2010-11-05 00:00:00

  • Binding of epidermal growth factor in rat pancreatic acini.

    abstract：:Specific, saturable EGF receptors were demonstrated in isolated rat pancreatic acini. Binding of EGF to these receptors was one-half maximal at 20 min and maximal at 120 min. Scatchard analyses revealed a single order of binding sites with a Kd of 4.90 nM. Following binding, EGF was rapidly internalized and converted ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91408-0

    authors： Korc M,Matrisian LM,Planck SR,Magun BE

    更新日期：1983-03-29 00:00:00