A new method for rapid assignment of S-S bridges in proteins.

abstract：:We have previously shown that a high cholesterol (HC) diet results in increases in microglia load and levels of the pro-inflammatory cytokine interleukin-6 (IL-6) in the brains of wild type (WT) and apolipoprotein E knockout (ApoE-/-) mice. In the present investigation, we analyzed whether treatment with rosuvastatin,...

journal_title：Biochemical and biophysical research communications

authors： Famer D,Wahlund LO,Crisby M

更新日期：2010-11-12 00:00:00

abstract：:1-4 interaction scaling factors are used in AMBER forcefields to reduce the exaggeration of short-range repulsion caused by the 6-12 Lennard-Jones potential and a nonpolarizable charge model and to obtain better agreements of small-molecule conformational energies with experimental data. However, the effects of these ...

journal_title：Biochemical and biophysical research communications

authors： Pang YP

更新日期：2015-02-06 00:00:00

abstract：INTRODUCTION:Multiple myeloma (MM) remains incurable due to high rates of relapse after various treatment regimens. WEE1 is a cell cycle related gene that regulates the G2/M checkpoint and promotes cell cycle suspension for consequent DNA repair. To date, there are clinical studies for the evaluation of WEE1 inhibitors...

journal_title：Biochemical and biophysical research communications

authors： Barbosa RSS,Dantonio PM,Guimarães T,de Oliveira MB,Fook Alves VL,Sandes AF,Fernando RC,Colleoni GWB

更新日期：2019-11-12 00:00:00

abstract：:CH31 B lymphomas represent a model for antigen-induced deletional tolerance of immature B lymphocytes, because cross-linking the B cell antigen receptor (BCR) induces G(1) phase arrest and apoptosis. We have recently demonstrated that BCR cross-linking leads to a transient activation of p38 mitogen-activated protein k...

journal_title：Biochemical and biophysical research communications

authors： Swart JM,Chiles TC

更新日期：2000-09-24 00:00:00

abstract：:Major blood stage antimalarial drugs like chloroquine and artemisinin target the heme detoxification process of the malaria parasite. Hemozoin formation reactions in vitro using the Plasmodium falciparum histidine-rich protein-2 (Pfhrp-2), lipids, and auto-catalysis are slow and could not explain the speed of detoxifi...

journal_title：Biochemical and biophysical research communications

authors： Pandey AV,Babbarwal VK,Okoyeh JN,Joshi RM,Puri SK,Singh RL,Chauhan VS

更新日期：2003-09-05 00:00:00

abstract：:The screening of small synthetic compound libraries is a useful means of identifying molecules that modulate various cellular responses. We screened more than 10,000 different small compounds and identified three synthetic compounds that stimulate arachidonic acid (AA) release in a combinational manner in neutrophil-l...

journal_title：Biochemical and biophysical research communications

authors： Bae YS,Park EY,Lee HY,Kang HK,Suh PG,Kwak JY,Ryu SH,Lee T

更新日期：2004-12-10 00:00:00

abstract：:Enhancer sequences analysed using the informational spectrum method (ISM) show a characteristic frequency at .0488. It has been shown that the characteristic frequency for some DNA binding proteins overlaps the characteristic frequency of their target DNA sequences. We suggest here that two types of proteins, homeopro...

journal_title：Biochemical and biophysical research communications

authors： Cosić I,Nesić D,Pavlović M,Williams R

更新日期：1986-12-15 00:00:00

abstract：:We recently reported that oviduct epithelial cells in culture produce endothelin (ET) and postulated that ET could play an important role in the contraction of the oviduct. In the present study using an organ chamber myograph system, we evaluated the contractile effects of ET-1 on bovine oviduct ampullary-isthmus segm...

journal_title：Biochemical and biophysical research communications

authors： Rosselli M,Imthurn B,Macas E,Keller PJ,Dubey RK

更新日期：1994-05-30 00:00:00

abstract：:Murine embryonic stem cell (mESC)-derived cardiomyocytes represent a promising source of cells for use in the development of models for studying early cardiac development as well as cell-based therapies in postnatal pathologies. Here, we report a highly efficient cardiac differentiation system in which high density em...

journal_title：Biochemical and biophysical research communications

authors： Lee MY,Cagavi Bozkulak E,Schliffke S,Amos PJ,Ren Y,Ge X,Ehrlich BE,Qyang Y

更新日期：2011-12-09 00:00:00

abstract：:Complementary DNAs, cDNAs, coding for iduronate sulfatase (IDS, E.C.3.1.6.13) have been isolated and characterized in man and mouse. The murine cDNA (MTA16) was highly homologous to the human counterpart. By screening the same mouse thymus cDNA library another cDNA (MTA13) was isolated: it is 1831 bp long and is ident...

journal_title：Biochemical and biophysical research communications

authors： Daniele A,Russo T,Ballabio A,Di Natale P

更新日期：1993-08-16 00:00:00

abstract：:Recent studies provide evidence that Sox4 is involved in regulating apoptosis as well as tumorigenesis of various human cancers; however, its role in the apoptotic machinery is not fully understood. Here we describe that the central domain containing glycine-rich region in Sox4, named CD, is a pivotal pro-apoptotic do...

journal_title：Biochemical and biophysical research communications

authors： Hur EH,Hur W,Choi JY,Kim IK,Kim HY,Yoon SK,Rhim H

更新日期：2004-12-03 00:00:00

abstract：:An infection of any part of female reproductive tract can severely interfere with fertility and reproduction. The fluids and epithelium from the lumen of the female reproductive tract (uterus, oviduct and ovarian follicle) are a known source of antimicrobial action in several species. In this study, we compared the an...

journal_title：Biochemical and biophysical research communications

authors： Dráb T,Kračmerová J,Hanzlíková E,Černá T,Litváková R,Pohlová A,Tichá M,Přikryl P,Liberda J

更新日期：2014-01-17 00:00:00

abstract：:Here, we demonstrate that interleukin-1β (IL-1β) contributes to the γ-ionizing radiation (IR)-induced increase of migration/invasion in A549 lung cancer cells, and that this occurs via RIP1 upregulation. We initially observed that the protein expression and secreted concentration of IL-1β were increased upon exposure ...

journal_title：Biochemical and biophysical research communications

authors： Kang AR,Cho JH,Lee NG,Kwon JH,Song JY,Hwang SG,Jung IS,Kim JS,Um HD,Oh SC,Park JK

更新日期：2021-01-01 00:00:00

abstract：:Liposomes prepared from lecithin:cholesterol:p-aminophenyl-alpha-mannoside (7:2:1, v/v/v) were efficiently incorporated into the mouse brain across the blood brain barrier. Furthermore, liposomes injected intraperitoneally were exclusively distributed into lysosome rich fraction and also taken up by glial cells. These...

journal_title：Biochemical and biophysical research communications

authors： Umezawa F,Eto Y

更新日期：1988-06-30 00:00:00

abstract：:Difluoromethylornithine (DFMO) depletes cells of polyamines, sensitizing cells against the action of antineoplastic drugs and altering ability to repair radiation-induced DNA strand breaks. Others have hypothesized that the mechanism by which polyamine depletion sensitizes cells is through inhibition of DNA strand bre...

journal_title：Biochemical and biophysical research communications

authors： Williams JR,Casero RA,Dillehay LE

更新日期：1994-05-30 00:00:00

abstract：:MazF is a sequence-specific endoribonuclease or mRNA interferase, which cleaves RNA at a specific sequence. Since the expression of a specific gene or a group of specific genes can be regulated by MazF, expanding the repertoire of recognition sequences by MazF mRNA interferases is highly desirable for biotechnological...

journal_title：Biochemical and biophysical research communications

authors： Ishida Y,Inouye K,Ming O,Inouye M

更新日期：2019-10-20 00:00:00

abstract：:A novel method using an amplifier with a cantilever and gold nanoparticles successfully to extend the length of the target for the specific and high sensitive detection of DNA was reported. When the size of gold nanoparticle is 50 nm, a sensitivity of 10(-15)M for the single base mutation detection has been achieved. ...

journal_title：Biochemical and biophysical research communications

authors： Liu T,Tang J,Han M,Jiang L

更新日期：2003-04-25 00:00:00

abstract：:To understand the molecular mechanisms involved in preleukemia, the suppression subtractive hybridization method was used in a murine radiation-induced thymic lymphoma model. Seventeen mRNAs overexpressed in preleukemic thymuses were identified: mouse laminin binding protein (p40/37LBP), E25 protein, Rattus norvegicus...

journal_title：Biochemical and biophysical research communications

authors： Verlaet M,Deregowski V,Denis G,Humblet C,Stalmans MT,Bours V,Castronovo V,Boniver J,Defresne MP

更新日期：2001-04-27 00:00:00

abstract：:Prion diseases are characterized by the accumulation of a pathological form of prion protein (PrP(Sc)), which behaves as an infectious agent. Here we developed an in vitro co-culture system to analyze the PrP(Sc) transmission from ScN2a cell, which persistently retains PrP(Sc), to naïve N2a cell. In this cell-to-cell ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka M,Hara H,Nishina H,Hanada K,Hagiwara K,Maehama T

更新日期：2010-07-02 00:00:00

abstract：:Arctigenin is a bioactive constituent from dried seeds of Arctium lappa L., which was traditionally used as medicine. Arctigenin exhibits various bioactivities, but its effects on blood pressure regulation are still not widely studied. In this study, we investigated antihypertensive effects of arctigenin by long-term ...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Wang G,Yang M,Chen H,zhao Y,Yang S,Sun C

更新日期：2015-12-25 00:00:00

abstract：:The vast majority of physiological processes in living cells are mediated by protein-protein interactions often specified by particular protein sequence motifs. PDZ domains, composed of 80-100 amino acid residues, are an important class of interaction motif. Among the PDZ-containing proteins, glutaminase interacting p...

journal_title：Biochemical and biophysical research communications

authors： Zencir S,Ovee M,Dobson MJ,Banerjee M,Topcu Z,Mohanty S

更新日期：2011-08-12 00:00:00

abstract：:Nitric oxide (NO) production is increased in the intestine and may contribute to intestinal injury in sepsis. However, the tissue expression of inducible NO synthase (iNOS) mRNA throughout the digestive tract and its relation with the mucosal damage after endotoxin challenge remain unknown. We therefore measured tissu...

journal_title：Biochemical and biophysical research communications

authors： Chen K,Inoue M,Okada A

更新日期：1996-07-25 00:00:00

abstract：:Myofibrillogenesis regulator-1(MR-1) can aggravate cardiac hypertrophy induced by angiotensin(Ang) II in mice through activation of NF-kappaB signaling pathway, and nuclear transcription factor (NF)-kappaB and activator protein-1(AP-1) regulate inflammatory and immune responses by increasing the expression of specific...

journal_title：Biochemical and biophysical research communications

authors： Dai W,Chen H,Jiang J,Kong W,Wang Y

更新日期：2010-01-15 00:00:00

abstract：:The signal transduction of human 12(S)-lipoxygenase and the regulation of gene activation, induced by epidermal growth factor (EGF), are discussed in this review article. Treatment of human epidermoid carcinoma A431 cells with EGF induces the gene expression of human 12(S)-lipoxygenase, and two Sp1 binding sites resid...

journal_title：Biochemical and biophysical research communications

authors： Chang WC,Chen BK

更新日期：2005-12-09 00:00:00

abstract：:Gastric cancer (GC) remains a serious threat to human health with a high cancer-related death rate and unsatisfactory treatment effects after curative resection, especially with advanced GC. Thus, exploration of the molecular mechanism of cisplatin (CDDP) resistance in GC is crucial. circCCDC66 (hsa_circ_0001313) expr...

journal_title：Biochemical and biophysical research communications

authors： Zhang Q,Miao Y,Fu Q,Hu H,Chen H,Zeng A,Jin Y,Jiang Y,Qian L,Wu L,Xu L,Wang G,Qiu L,Huang X,Xia Y

更新日期：2020-06-04 00:00:00

abstract：:Parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor expressed in rat cultured cortical type I astrocytes was identified and characterized. Northern blot analysis demonstrated that the PTH/PTHrP receptor mRNA is expressed in astrocytes. A human PTH fragment, PTH [1-34], stimulated adenylate c...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto H,Aino H,Ogawa N,Nagata S,Baba A

更新日期：1994-04-29 00:00:00

abstract：:The cyclin-dependent kinase (CDK) inhibitor p27(Kip1) is an important regulator of cell cycle progression as it negatively regulates G(0/1) progression and plays a major role in controlling the cell cycle. The screening of the p27(Kip1) sequence identified many potential phosphorylation sites. Although Ser(10) and Thr...

journal_title：Biochemical and biophysical research communications

authors： Guan X,Chen L,Wang J,Geng H,Chu X,Zhang Q,Du L,De W

更新日期：2006-09-01 00:00:00

abstract：:The signal transduction pathway involved in hepatocyte growth factor (HGF)-induced capillary morphogenesis of endothelial cells was investigated. HGF-induced capillary morphogenesis of the murine spleen endothelial cell line MSS31 was inhibited by a Src family kinase inhibitor, PP2. Stable expression of kinase-inactiv...

journal_title：Biochemical and biophysical research communications

authors： Kanda S,Kanetake H,Miyata Y

更新日期：2006-06-02 00:00:00

abstract：:Cone photoreceptor subtypes having different spectral sensitivities exhibit different recovery kinetics in their photoresponses in some vertebrates. Phosphorylation by G protein-coupled receptor kinase (GRK) is essential for the rapid inactivation of light-activated visual pigment, which is the rate-limiting step of t...

journal_title：Biochemical and biophysical research communications

authors： Tsutsui K,Tachibanaki S,Shimauchi-Matsukawa Y,Shichida Y,Kawamura S

更新日期：2013-11-01 00:00:00

abstract：:Interleukin 6 is a cytokine with growth and differentiation activities on a number of cell types. Human articular chondrocytes produce interleukin 6 and this production appears to be constitutive but can be stimulated in a dose-dependent manner by interleukin 1. Other stimulators of interleukin 6 production in chondro...

journal_title：Biochemical and biophysical research communications

authors： Bunning RA,Russell RG,Van Damme J

更新日期：1990-02-14 00:00:00