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Heat shock induces phosphorylation of histone H2AX in mammalian cells.

Abstract：

:Heat shock induces a variety of biological events including gene activation, cell cycle arrest, and apoptosis. Heat shock has recently been shown to be potentially useful when combined with radiation in cancer therapy, probably because, in mammalian cells, heat inhibits the repair of double-strand breaks (DSBs) induced by ionizing radiation. It remains unclear, however, whether heat shock by itself induces DSBs. In this communication, we present the first evidence that heat shock induces the phosphorylated form of histone H2AX, which is thought to be generated at the chromatin proximal to DSB sites. These results suggest that heat shock induces DSBs in mammalian cells and may provide direct evidence to explain previous reports on DSB-related events occurring after heat shock treatment.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kaneko H,Igarashi K,Kataoka K,Miura M

doi

10.1016/j.bbrc.2005.01.073

subject

Has Abstract

pub_date

2005-03-25 00:00:00

pages

1101-6

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)00101-4

journal_volume

328

pub_type

杂志文章

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