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Microinjection of an nm23 specific antibody inhibits cell division in rat embryo fibroblasts.

Abstract：

:Expression of the nm23/NDP-K gene correlates with reduced metastasis in some tumors and with increased proliferation in both nontransformed and transformed cells in culture. Decreased nm23/NDP-K expression results in mitotic arrest in neuroblasts of developing Drosophila. In order to better understand the biological role(s) of nm23 in non-transformed cells, an nm23-specific antibody was introduced into rat embryo fibroblasts and effects on DNA synthesis and cell cycle progression were analyzed. Microinjection of the nm23 antibody inhibited cell division with no apparent effect on DNA synthesis. Control experiments revealed that the survival of cells injected with the nm23 antibody was similar to that of control antibody injected cells in the absence of cell division. These results suggest that in mammalian fibroblasts, as in Drosophila, nm23 expression may be necessary for progression through the cell cycle.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sorscher SM,Steeg P,Feramisco JR,Buckmaster C,Boss GR,Meinkoth J

doi

10.1006/bbrc.1993.2049

subject

Has Abstract

pub_date

1993-08-31 00:00:00

pages

336-45

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)72049-8

journal_volume

195

pub_type

杂志文章

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