Development of a novel analgesic for neuropathic pain targeting brain-derived neurotrophic factor.

abstract：:Parathymosin has been purified from calf liver and its primary sequence established, except for a segment containing approximately 11 amino acid residues in the central part of the polypeptide chain. Bovine parathymosin contains approximately 101 amino acid residues and shows 90% identity with rat parathymosin, with s...

journal_title：Biochemical and biophysical research communications

authors： Panneerselvam C,Clinton M,Wellner D,Horecker BL

更新日期：1988-09-15 00:00:00

abstract：:In order to understand gene regulation during wood formation, we cloned a MYB46-like gene in hybrid aspen, Populus tremula x tremuloides, called Pt x tMYB021. Phylogenetic and paired identity analysis of MYB46-like genes in Populus and Arabidopsis reveals relationships between paralogous pairs of Populus MYB46-like pr...

journal_title：Biochemical and biophysical research communications

authors： Winzell A,Aspeborg H,Wang Y,Ezcurra I

更新日期：2010-04-09 00:00:00

abstract：:To date, tick-borne flaviviruses responsible for hemorrhagic fever in humans have been isolated in Siberia (Omsk hemorrhagic fever virus), India (Kyasanur Forest disease virus, KFDV), and in Saudi Arabia (Alkhurma virus, ALKV). Prior to this study, only partial coding sequences of these severe pathogens had been deter...

journal_title：Biochemical and biophysical research communications

authors： Charrel RN,Zaki AM,Attoui H,Fakeeh M,Billoir F,Yousef AI,de Chesse R,De Micco P,Gould EA,de Lamballerie X

更新日期：2001-09-21 00:00:00

abstract：:Estrogen receptor alpha (ERα) is a nuclear receptor that regulates a range of physiological processes in response to estrogens. In order to study its biological role, we generated a floxed ERα mouse line that can be used to knock out ERα in selected tissues by using the Cre/LoxP system. In this study, we established a...

journal_title：Biochemical and biophysical research communications

authors： Antonson P,Omoto Y,Humire P,Gustafsson JÅ

更新日期：2012-08-10 00:00:00

abstract：:The effect of vitamin A on the expression of apoAI and CIII genes in intact rats was studied. In vitamin A-deficient rats, the hepatic level of apoAI mRNA was increased and enhanced by an oral administration of excess retinoic acid(RA). A similar administration to normal rats caused an increase in the apoAI mRNA level...

journal_title：Biochemical and biophysical research communications

authors： Nagasaki A,Kikuchi T,Kurata K,Masushige S,Hasegawa T,Kato S

更新日期：1994-12-30 00:00:00

abstract：:The nitric oxide synthases (NOS) are a class of enzymes responsible for the generation of NO via an oxygen and NADPH dependent oxidation of the amino acid arginine. These enzymes are ironheme proteins which contain FAD and FMN and, enigmatically, require tetrahydrobiopterin (BH4). NOS has recently been shown to be sub...

journal_title：Biochemical and biophysical research communications

authors： Hyun J,Komori Y,Chaudhuri G,Ignarro LJ,Fukuto JM

更新日期：1995-01-05 00:00:00

abstract：:The transcriptional regulator BrlR is a member of the MerR family of multidrug transport activators in Pseudomonas aeruginosa. Recent study indicates that BrlR is a novel 3',5'-cyclic diguanylic acid (c-di-GMP) receptor and can be activated by c-di-GMP. To gain insight into BrlR function, we determined the structure o...

journal_title：Biochemical and biophysical research communications

authors： Raju H,Sharma R

更新日期：2017-08-19 00:00:00

abstract：:The understanding of capsid (C) protein interactions with itself would provide important data on how the core is organized in flaviviruses during assembly. In this study, West Nile (WN) virus C protein was shown to form homodimers using yeast two-hybrid analysis in conjunction with mammalian two-hybrid and in vivo co-...

journal_title：Biochemical and biophysical research communications

authors： Bhuvanakantham R,Ng ML

更新日期：2005-04-01 00:00:00

abstract：:Oncogenic osteomalacia (OOM), X-linked hypophosphatemia (XLH), and autosomal dominant hypophosphatemic rickets (ADHR) are phenotypically similar disorders characterized by hypophosphatemia, decreased renal phosphate reabsorption, normal or low serum calcitriol concentrations, normal serum concentrations of calcium and...

journal_title：Biochemical and biophysical research communications

authors： Bowe AE,Finnegan R,Jan de Beur SM,Cho J,Levine MA,Kumar R,Schiavi SC

更新日期：2001-06-22 00:00:00

abstract：:Predicting acute clinical events caused by atherosclerotic plaque rupture remains a clinical challenge. Anatomic mapping of the vascular tree provided by standard imaging technologies is not always sufficient for a robust diagnosis. Yet biological mechanisms leading to unstable plaques have been identified and corresp...

journal_title：Biochemical and biophysical research communications

authors： Juenet M,Varna M,Aid-Launais R,Chauvierre C,Letourneur D

更新日期：2015-12-18 00:00:00

abstract：:SARS-like coronavirus (SL-CoV) in bats have a similar genomic organization to the human SARS-CoV. Their cognate gene products are highly conserved with the exception of the N-terminal region of the S proteins, which have only 63-64% sequence identity. The N-terminal region of coronavirus S protein is responsible for v...

journal_title：Biochemical and biophysical research communications

authors： Zhou P,Han Z,Wang LF,Shi Z

更新日期：2009-09-18 00:00:00

abstract：:Borate/boric acid solutions have distinctive effects on the absorption and fluorescence emission spectra of dityrosine. In the presence of excess borate/boric acid, the fluorescence emission maximum of the singly ionized dityrosine chromophore shifts from 407 nm (quantum yield = 0.80) to 374 nm (quantum yield = 0.14)....

journal_title：Biochemical and biophysical research communications

authors： Malencik DA,Anderson SR

更新日期：1991-07-15 00:00:00

abstract：:The adipose tissue of genetically obese Zucker rats is characterized by coordinated tissue specific overtranscription of a subset of genes related to lipid storage such as Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH). We show that CCAAT/Enhancer Binding Protein alpha (C/EBP alpha) is an activator of GAPDH proximal...

journal_title：Biochemical and biophysical research communications

authors： Rolland V,Le Liepvre X,Houbiguian ML,Lavau M,Dugail I

更新日期：1995-02-15 00:00:00

abstract：:Long term function of human lung allografts is hindered by development of chronic rejection manifested as Bronchiolitis Obliterans Syndrome (BOS). We have previously identified the development of antibodies (Abs) following lung transplantation to K-alpha1-tubulin (KAT), an epithelial surface gap junction cytoskeletal ...

journal_title：Biochemical and biophysical research communications

authors： Tiriveedhi V,Angaswamy N,Weber J,Mohanakumar T

更新日期：2010-08-20 00:00:00

abstract：:The Wnt signaling pathway is crucial for development and disease. The regulation of Wnt protein trafficking is one of the pivotal issues in the Wnt research field. Here we performed a genetic screen in Drosophila melanogaster for genes involved in Wingless/Wnt secretion, and identified the p24 protein family members B...

journal_title：Biochemical and biophysical research communications

authors： Li X,Wu Y,Shen C,Belenkaya TY,Ray L,Lin X

更新日期：2015-08-07 00:00:00

abstract：:Prolactin, the Janus kinase 2 (JAK2) and the signal transducer and activator of transcription 5 (STAT5) are important for mammary gland development and have also been implicated in development and growth of breast tumors. In the present study we have investigated the role for JAK2 in proliferation, differentiation, an...

journal_title：Biochemical and biophysical research communications

authors： Olsen H,Hedengran Faulds MA,Saharinen P,Silvennoinen O,Haldosén LA

更新日期：2002-08-09 00:00:00

abstract：:Ritonavir, an inhibitor of HIV-1 protease, has been reported to also inhibit the Ca2+-dependent cysteine protease, calpain. We have investigated these claims with an in vitro study of the effect of ritonavir on the m-calpain and mu-calpain isoforms. Ritonavir failed to block either autolytic or hydrolytic calpain acti...

journal_title：Biochemical and biophysical research communications

authors： Cuerrier D,Nie Z,Badley AD,Davies PL

更新日期：2005-02-04 00:00:00

abstract：:GLM, a luteolin derivative, shows anti-melanogenic effect via regulation of various signal molecules; however, it is unclear whether it also exerts anti-inflammatory effect. This study investigated the mechanisms of the anti-inflammatory effect of GLM on activated dendritic cells (DCs) to elucidate its therapeutic pot...

journal_title：Biochemical and biophysical research communications

authors： Kim WS,Song HY,Han JM,Byun EB

更新日期：2019-10-08 00:00:00

abstract：:Molecular analysis of the induction of the lutropin/choriogonadotropin receptor during the process of luteinization of the rat ovary was performed. The appearance of receptor binding activity and an immunological analysis of the receptor using Triton solubilized membrane proteins show little receptor present in luteal...

journal_title：Biochemical and biophysical research communications

authors： Hansbury MJ,McIlroy PJ,Goldenthal MJ

更新日期：1990-09-14 00:00:00

abstract：:Pathological cardiac hypertrophy, often accompanied by hypertension, aortic stenosis and valvular defects, is typically associated with myocyte remodeling and cardiac dysfunction. Exercise preconditioning (EP) has been proven to enhance the tolerance of the myocardium to cardiac ischemia-reperfusion injury. However, t...

journal_title：Biochemical and biophysical research communications

authors： Xu T,Zhang B,Yang F,Cai C,Wang G,Han Q,Zou L

更新日期：2015-05-08 00:00:00

abstract：:Down syndrome (DS, Trisomy 21) is the most common genetic cause of delayed fetal brain development and postnatal intellectual disability. Although delayed fetal brain development might be involved in intellectual disability, no evidence of an association between these abnormal phenotypes has been shown. To identify mo...

journal_title：Biochemical and biophysical research communications

authors： Shimizu R,Ishihara K,Kawashita E,Sago H,Yamakawa K,Mizutani KI,Akiba S

更新日期：2021-01-08 00:00:00

abstract：:P-glycoprotein (P-gp) is required for adaptive immunity through defined functions in T cell activation and antigen presenting cell (APC) maturation. The potential role of P-gp as an in vivo regulator of alloimmunity is currently unknown. Here we show that P-gp blockade prolongs graft survival in a murine heterotopic c...

journal_title：Biochemical and biophysical research communications

authors： Izawa A,Schatton T,Frank NY,Ueno T,Yamaura K,Pendse SS,Margaryan A,Grimm M,Gasser M,Waaga-Gasser AM,Sayegh MH,Frank MH

更新日期：2010-04-09 00:00:00

abstract：:We studied the effects of interleukin-6(IL-6) on DNA synthesis and cyclic AMP production in rat thyroid FRTL-5 cells. When cells were incubated with IL-6 in the presence or absence of IGF-I, cell proliferation was not observed. By contrast, IL-6 stimulated DNA synthesis in a dose dependent manner when TSH was added co...

journal_title：Biochemical and biophysical research communications

authors： Nishiyama S,Takada K,Tada H,Takano T,Amino N

更新日期：1993-04-15 00:00:00

abstract：:Leishmania promastigotes have the ability to synthesize essential polyunsaturated fatty acids de novo and can grow in lipid free media. Recently, we have shown that NAD(P)H cytochrome b5 oxidoreductase (Ncb5or) enzyme in Leishmania acts as the redox partner for Δ12 fatty acid desaturase, which catalyses the conversion...

journal_title：Biochemical and biophysical research communications

authors： Mukherjee A,Adhikari A,Das P,Biswas S,Mukherjee S,Adak S

更新日期：2018-09-03 00:00:00

abstract：:Human Cla-1 is the likely homologue of the murine scavenger receptor class B type I (SR-BI). SR-BI mediates selective transfer of cholesterol to high-density lipoprotein (HDL) and the efflux of endogenously synthesized and plasma membrane sterols to HDL. HDL protects against atherosclerosis but also reduces endotoxic ...

journal_title：Biochemical and biophysical research communications

authors： Buechler C,Ritter M,Quoc CD,Agildere A,Schmitz G

更新日期：1999-08-19 00:00:00

abstract：:Expression of ALP in F9 teratocarcinoma cells is induced by all-trans retinoic acid (ATRA) (Gianni' et al., Biochem. J. 274: 673-678, 1991). The specific ligand for retinoic acid related receptors (RXRs), 9-cis retinoic acid (9-cis RA), and three synthetic analogs binding to the alpha, beta and gamma forms of the reti...

journal_title：Biochemical and biophysical research communications

authors： Gianni M,Zanotta S,Terao M,Garattini S,Garattini E

更新日期：1993-10-15 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) from adult bone marrow are able to differentiate into adipocytes, osteoblasts, chondrocytes and neuronal cells. Adipocytes in bone marrow are primarily responsible for the maintenance of bone structure by maintaining cell number balance with other stromal cells. However, the number...

journal_title：Biochemical and biophysical research communications

authors： Kim M,Lee YJ,Jee SC,Choi I,Sung JS

更新日期：2016-01-01 00:00:00

abstract：:While Wnt and Ras signaling pathways are activated during progression of colorectal cancers, many of their important downstream targets remain to be elucidated. The gastrin gene encodes for a family of peptide growth factors that are commonly upregulated in colorectal neoplasia. Previously, we showed that the Wnt sign...

journal_title：Biochemical and biophysical research communications

authors： Chakladar A,Dubeykovskiy A,Wojtukiewicz LJ,Pratap J,Lei S,Wang TC

更新日期：2005-10-14 00:00:00

abstract：:Methylated lysyl and arginyl residues are present in the two major heat shock proteins, hsp70A and hsp70B, of chicken embryo fibroblasts. Here, we demonstrate that this methylation can be modulated by sodium arsenite, a chemical that increases the synthesis of hsp70. In particular, in hsp70A the amount of epsilon-N-tr...

journal_title：Biochemical and biophysical research communications

authors： Wang C,Lazarides E

更新日期：1984-03-15 00:00:00

abstract：:The anomeric proton of the reducing N-acetylglucosamine residue of beta-N,N'-diacetylchitobiose exhibited an unusual lineshape indicative of virtual coupling in the 250 MHz proton NMR spectrum. The two-dimensional J-resolved spectrum contained four lines associated with this proton, and this pattern can be used to dis...

journal_title：Biochemical and biophysical research communications

authors： Bruch RC,Bruch MD,Noggle JH,White HB 3rd

更新日期：1984-09-17 00:00:00