Crystal structure of BrlR with c-di-GMP.

abstract：:Changes in the intermediate filament composition of rat kidney proximal tubule cells in culture have been investigated. The data suggest that differentiated tubular epithelial cells do not express vimentin, but vimentin expression is induced when the cells begin to proliferate in culture. The cultured cells are positi...

journal_title：Biochemical and biophysical research communications

authors： Hatzinger PB,Chen Q,Dong LQ,Stevens JL

更新日期：1988-12-30 00:00:00

abstract：:The postnatal development and molecular properties of somatostatin receptor were studied in rat cerebral cortex. With [125I-Tyr11]SRIF as a radiolabeled ligand, the specific ligand binding to crude membrane increased transiently in the early phase of postnatal development and then decreased. This increase of somatosta...

journal_title：Biochemical and biophysical research communications

authors： Kimura N

更新日期：1989-04-14 00:00:00

abstract：:Antileukoprotease (ALP) was isolated from bronchial secretion. The amino acid composition as well as the N-terminal sequence were determined. No homology with other low molecular weight proteinase inhibitors was found. ...

journal_title：Biochemical and biophysical research communications

authors： Klasen EC,Kramps JA

更新日期：1985-04-16 00:00:00

abstract：:Seleno compounds such as selenocystamine and seleno-D, L-cystine were found to catalyze the decomposition of S-nitrosothiols (e.g. S-nitroso-glutathione and S-nitroso-N-acetyl-D, L-penicillamine) in the presence of different thiols (e.g. glutathione, N-acetyl-D-penicillamine and 2-mercaptoethanol), and liberate nitric...

journal_title：Biochemical and biophysical research communications

authors： Hou Y,Guo Z,Li J,Wang PG

更新日期：1996-11-01 00:00:00

abstract：:The short-term incubation of HeLa cells in the presence of diferric transferrin or ferricyanide, which are reduced externally by the transplasma membrane reductase, produces a stoichiometric decrease in NADH and increase in NAD+, which is stimulated by insulin. The NADP/NADPH ratio does not change during 15 min incuba...

journal_title：Biochemical and biophysical research communications

authors： Navas P,Sun IL,Morré DJ,Crane FL

更新日期：1986-02-26 00:00:00

abstract：:Tissue factor (TF) is an initiation factor for blood coagulation and its expression is induced on endothelial cells during inflammatory or immune responses. We designed an antisense oligodeoxynucleotide (AS-1/TF) for rat TF and studied its effect on hepatic ischemic reperfusion injury. AS-1/TF was delivered intravenou...

journal_title：Biochemical and biophysical research communications

authors： Nakamura K,Kadotani Y,Ushigome H,Akioka K,Okamoto M,Ohmori Y,Yaoi T,Fushiki S,Yoshimura R,Yoshimura N

更新日期：2002-09-27 00:00:00

abstract：:The TOR pathway is a kinase signaling pathway that regulates cellular growth and proliferation in response to nutrients and growth factors. TOR signaling is also important in lifespan regulation - when this pathway is inhibited, either naturally, by genetic mutation, or by pharmacological means, lifespan is extended. ...

journal_title：Biochemical and biophysical research communications

authors： Khan MH,Hart MJ,Rea SL

更新日期：2012-08-24 00:00:00

abstract：:We have investigated whether isolated mouse hepatic sinusoidal endothelial cells (HSEC) synthesized basic FGF. HSEC lysate was fractionated by heparin-Sepharose chromatography. A peak of mitogenic activity for Balb/c 3T3 fibroblasts was eluted with 3M NaCl. Several arguments suggested that the mitogenic factor was rel...

journal_title：Biochemical and biophysical research communications

authors： Rosenbaum J,Mavier P,Preaux AM,Dhumeaux D

更新日期：1989-11-15 00:00:00

abstract：:The cell surface receptor integrin is involved in signaling mechanical stresses via the focal adhesion complex (FAC) into the cell. Within FAC, the focal adhesion kinase (FAK) and Pyk2 are believed to act as important scaffolding proteins. Based on the knowledge that many signal transducing molecules are transiently i...

journal_title：Biochemical and biophysical research communications

authors： Klemm AH,Kienle S,Rheinlaender J,Schäffer TE,Goldmann WH

更新日期：2010-03-19 00:00:00

abstract：:The mechanism of tumour necrosis factor-mediated cytotoxicity was investigated by using various inhibitors of arachidonic acid metabolism. Phospholipase A2 inhibitors with different modes of action interfered with the cytotoxic action of TNF, whereas phospholipase C inhibitors did not. Neither cyclooxygenase nor lipox...

journal_title：Biochemical and biophysical research communications

authors： Suffys P,Beyaert R,Van Roy F,Fiers W

更新日期：1987-12-16 00:00:00

abstract：:Slo3 channels (mSlo3) primarily mediate mouse sperm K(+) currents and are essential for the capacitation-associated hyperpolarization (CAH). Whether Slo3 and/or Slo1, two Slo family K(+) channels are functionally expressed in human sperm is controversial. Our recent pharmacological studies of the human sperm CAH sugge...

journal_title：Biochemical and biophysical research communications

authors： Sánchez-Carranza O,Torres-Rodríguez P,Darszon A,Treviño CL,López-González I

更新日期：2015-10-23 00:00:00

abstract：:A phosphate buffer containing a mixture of glucose oxidase, acrylic acid derivatives, N,N'-1,2 dihydroxy-ethylene-bis(acrylamide), N,N'-(methylene)-bisacrylamide and surface-modified silica was radically polymerized with (NH4)2S2O8. The polymer formed a thin layer around the silica beads. After sieving of these polyme...

journal_title：Biochemical and biophysical research communications

authors： Burow M,Minoura N

更新日期：1996-10-14 00:00:00

abstract：:The polyamines spermidine, spermine and putrescine, by themselves, at physiological concentrations, induce the transport of the precursor of ornithine carbamoyltransferase into isolated rat liver mitochondria. The presence of polyamines in the transport medium results in the approach of both mitochondrial membranes, s...

journal_title：Biochemical and biophysical research communications

authors： Marcote MJ,González-Bosch C,Miralles VJ,Hernández-Yago J,Grisolía S

更新日期：1989-01-16 00:00:00

abstract：:The kinetic parameters of several substrates of penicillin acylase from Streptomyces lavendulae have been determined. The enzyme hydrolyses phenoxymethyl penicillin (penicillin V) and other penicillins with aliphatic acyl-chains such as penicillin F, dihydroF, and K. The best substrate was penicillin K (octanoyl penic...

journal_title：Biochemical and biophysical research communications

authors： Torres-Guzmán R,de la Mata I,Torres-Bacete J,Arroyo M,Castillón MP,Acebal C

更新日期：2002-03-01 00:00:00

abstract：:Our previous data from a human leukemic cell line made resistant to the nucleoside analog (NA) 9-β-D-arabinofuranosylguanine (AraG) revealed a massive upregulation of fetal hemoglobin (HbF) genes and the ABCB1 gene coding for the multidrug resistance P-glycoprotein (P-gp). The expression of these genes is regulated th...

journal_title：Biochemical and biophysical research communications

authors： Fyrberg A,Skoglund K,Wolk M,Lotfi K

更新日期：2012-10-26 00:00:00

abstract：:The mode of action of dihydroxyanthraquinone, a new antitumor drug, on eucaryotic chromosome structure and function was investigated using simian virus 40 as a model system. Dihydroxyanthraquinone specifically inhibited initiation of viral replicons. Little or no viral DNA synthesis was recovered in cells after the re...

journal_title：Biochemical and biophysical research communications

authors： Su RT,Ma XJ,Cheng CC

更新日期：1985-07-16 00:00:00

abstract：:The death of cardiomyocytes after myocardial infarction (MI) often leads to ventricular remodeling as well as heart failure (HF). The cardiac progenitor cells (CPCs) have the ability to regenerate functional heart muscle in patients after MI, which provides a promising method for MI-induced HF therapy. However, to dat...

journal_title：Biochemical and biophysical research communications

authors： Li L,Wang Q,Yuan Z,Chen A,Liu Z,Wang Z,Li H

更新日期：2018-05-15 00:00:00

abstract：:X-linked Emery-Dreifuss muscular dystrophy is usually caused by absence of the nuclear membrane protein, emerin, due to nonsense mutations or deletions, but a few missense mutations also exist. A pathogenic g993t mutation causes a Q133H change in the nuclear targeting region of emerin, but it may also reduce emerin le...

journal_title：Biochemical and biophysical research communications

authors： Holt I,Clements L,Manilal S,Morris GE

更新日期：2001-10-12 00:00:00

abstract：:As vectors, adenoviruses (Ads) have many attractive advantages for in vivo gene therapy. However, Ads do not usually integrate into the host genome and gene expression is, thus, transient. Adeno-associated virus (AAV) integrates into a specific locus (AAVS1) on the human host's chromosome 19, while conventional recomb...

journal_title：Biochemical and biophysical research communications

authors： Ueno T,Matsumura H,Tanaka K,Iwasaki T,Ueno M,Fujinaga K,Asada K,Kato I

更新日期：2000-07-05 00:00:00

abstract：:Because of the growing importance of the Retinoid X Receptors (RXR alpha, beta and gamma) in the retinoid acid signalling pathway, we have prepared polyclonal and monoclonal antibodies directed against these proteins. For this purpose, either the whole mouse RXR alpha protein expressed in E.Coli, or synthetic peptides...

journal_title：Biochemical and biophysical research communications

authors： Rochette-Egly C,Lutz Y,Pfister V,Heyberger S,Scheuer I,Chambon P,Gaub MP

更新日期：1994-10-28 00:00:00

abstract：:Lon protease has been well studied in many aspects; however, the DNA-binding specificity of Lon in prokaryotes has not been clearly identified. Here we examined the DNA-binding activity of Lon protease alpha-domains from Brevibacillus thermoruber (Bt), Bacillus subtilis (Bs), and Escherichia coli (Ec). MALDI-TOF mass ...

journal_title：Biochemical and biophysical research communications

authors： Lin YC,Lee HC,Wang I,Hsu CH,Liao JH,Lee AY,Chen C,Wu SH

更新日期：2009-10-09 00:00:00

abstract：:Male Djungarian hamsters (Phodopus sungorus; 45 animals per group) were either sham-exposed or exposed to a sinusoidal magnetic field for 56 days (Experiment 1: 50 Hz, 450 microTesla peak; max. dB/dt = 140 mTesla s(-1); 24 hrs day(-1)). Except for day 7, no effects were observed with respect to body weights during exp...

journal_title：Biochemical and biophysical research communications

authors： Niehaus M,Brüggemeyer H,Behre HM,Lerchl A

更新日期：1997-05-29 00:00:00

abstract：:Sepsis, the systemic response to infection, is the leading cause of death in the intensive care units worldwide. Septic patients can succumb through the development of early refractory hypotension or late multiple organ dysfunction. Misregulation of apoptosis during sepsis may contribute to cellular dysfunction and mu...

journal_title：Biochemical and biophysical research communications

authors： Brabant D,Michael P,Bleiblo F,Saleh M,Narain R,Tai TC,Ramana CV,Parrillo JE,Kumar A,Kumar A

更新日期：2011-08-26 00:00:00

abstract：:Gastric inhibitory polypeptide (GIP) is released from the small intestine upon meal ingestion and increases insulin secretion from pancreatic β cells. Although the GIP receptor is known to be expressed in small intestine, the effects of GIP in small intestine are not fully understood. This study was designed to clarif...

journal_title：Biochemical and biophysical research communications

authors： Ogawa E,Hosokawa M,Harada N,Yamane S,Hamasaki A,Toyoda K,Fujimoto S,Fujita Y,Fukuda K,Tsukiyama K,Yamada Y,Seino Y,Inagaki N

更新日期：2011-01-07 00:00:00

abstract：:A few decades ago, researchers found emerging evidence showing that a number of sequential events lead to the pathological cascade of Alzheimer's disease (AD) which is caused by the accumulation of amyloid beta (Aβ), a physiological peptide, in the brain. Therefore, regulation of Aβ represents a crucial treatment appr...

journal_title：Biochemical and biophysical research communications

authors： Oh JH,Choi S,Shin J,Park JS

更新日期：2016-09-02 00:00:00

abstract：:Transforming growth factor alpha (TGF alpha) induces dose- and time-dependent stimulation of prostacyclin (PGI2) production by cultured human umbilical vein endothelial cells. The lowest stimulatory concentration of TGF alpha was 0.1 ng/ml and the maximal response, a 2.7-fold rise, was obtained with 10 ng/ml. The stim...

journal_title：Biochemical and biophysical research communications

authors： Ristimäki A

更新日期：1989-05-15 00:00:00

abstract：:MicroRNA-125a exhibits an antiproliferative activity and is downregulated in several types of tumors, including hepatocellular carcinoma where it targets sirtuin-7, matrix metalloproteinase-11, and c-Raf. Another target of miR-125a is Lin28, a pluripotency factor that is generally undetectable in differentiated cells ...

journal_title：Biochemical and biophysical research communications

authors： Panella M,Mosca N,Di Palo A,Potenza N,Russo A

更新日期：2018-06-07 00:00:00

abstract：:Hypoxia-inducible factors are crucial in the regulatory process of oxygen homeostasis of vertebrate cells. Inhibition of prolyl hydroxylation of HIF-alpha subunits by prolyl-hydroxylases (PHD1, PHD2 and PHD3) leads to transcription of a greater number of hypoxia responsive genes. We have investigated the subcellular d...

journal_title：Biochemical and biophysical research communications

authors： Steinhoff A,Pientka FK,Möckel S,Kettelhake A,Hartmann E,Köhler M,Depping R

更新日期：2009-10-02 00:00:00

abstract：:Inducible 6-phosphofructo-2-kinase (iPFK-2; PFKFB3) produces fructose-2,6-bisphosphate (F2,6BP), which is a potent allosteric activator of 6-phosphofructo-1-kinase (PFK-1), the rate-limiting step in glycolysis. iPFK-2 functions as an activator of anaerobic glycolysis within the hypoxic microenvironment of growing tumo...

journal_title：Biochemical and biophysical research communications

authors： Chesney J,Telang S,Yalcin A,Clem A,Wallis N,Bucala R

更新日期：2005-05-27 00:00:00

abstract：:A cDNA for tetrameric carbonyl reductase was cloned from a pig lung cDNA library. The cDNA had an open reading frame encoding a protein of 244 amino acid residues with a predicted monomer molecular weight of 25,985. The authenticity of the cDNA was confirmed by a perfect match of 80 amino acids determined from sequenc...

journal_title：Biochemical and biophysical research communications

authors： Nakanishi M,Deyashiki Y,Nakayama T,Sato K,Hara A

更新日期：1993-08-16 00:00:00