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Ritonavir does not inhibit calpain in vitro.

Abstract：

:Ritonavir, an inhibitor of HIV-1 protease, has been reported to also inhibit the Ca2+-dependent cysteine protease, calpain. We have investigated these claims with an in vitro study of the effect of ritonavir on the m-calpain and mu-calpain isoforms. Ritonavir failed to block either autolytic or hydrolytic calpain activity, but remained fully capable of inhibiting the HIV-1 protease. Any calpain-related effects of ritonavir in cells must, therefore, arise by a mechanism other than direct inhibition of calpains.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cuerrier D,Nie Z,Badley AD,Davies PL

doi

10.1016/j.bbrc.2004.11.161

subject

Has Abstract

pub_date

2005-02-04 00:00:00

pages

208-11

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)02736-6

journal_volume

327

pub_type

杂志文章

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