Lysis of trypanosomes by peptidyl fluoromethyl ketones.

abstract：:The factors which control the formation of lactiferous ducts during mammary gland development are not yet fully understood. To address this issue, we assessed the effect of the multifunctional cytokine transforming growth factor-beta-1 (TGF-beta1) on the morphogenetic properties of TAC-2.1 mammary epithelial cells gro...

journal_title：Biochemical and biophysical research communications

authors： Soriano JV,Orci L,Montesano R

更新日期：1996-03-27 00:00:00

abstract：:Protein, mRNA and activity levels of the calcium-independent protein kinase C (nPKC) isoenzymes were examined in NG108-15 cells. Western blot analyses reveal that proliferating NG 108-15 cells express the delta, epsilon, and eta, but not the theta species. The atypical species PKC zeta was also detected. Differentiati...

journal_title：Biochemical and biophysical research communications

authors： Battaini F,Pascale A,Lucchi L,Racchi M,Bergamaschi S,Parenti M,Wetsel WC,Govoni S,Trabucchi M

更新日期：1994-09-30 00:00:00

abstract：:CRTH2, the second receptor for prostaglandin D(2) (PGD(2)), is thought to play a role in allergic inflammations through the induction of chemotactic migration and/or the activation of Th2, eosinophils, and basophils, in humans. We previously identified the mouse CRTH2 homolog of human CRTH2 and suggest that animal mod...

journal_title：Biochemical and biophysical research communications

authors： Hirai H,Abe H,Tanaka K,Takatsu K,Sugamura K,Nakamura M,Nagata K

更新日期：2003-08-08 00:00:00

abstract：:The oral mucosa is an active though poorly understood immunological site. Using an experimental animal system involving antigen priming into the oral mucosa of transgenic mice expressing T cell receptor (TCR) for a peptide antigen of hen-egg lysozyme (HEL), the expression of six chemokine receptors and seven chemokine...

journal_title：Biochemical and biophysical research communications

authors： Otten K,Dragoo J,Wang HC,Klein JR

更新日期：2003-04-25 00:00:00

abstract：:Contact inhibition is a crucial mechanism regulating proliferation in vitro and in vivo. Despite its generally accepted importance for maintaining tissue homeostasis knowledge about the underlying molecular mechanisms of contact inhibition is still scarce. Since the MAPK ERK1/2 plays a pivotal role in the control of p...

journal_title：Biochemical and biophysical research communications

authors： Küppers M,Faust D,Linz B,Dietrich C

更新日期：2011-03-18 00:00:00

abstract：:Recent studies have identified a positive role for nitric oxide (NO) in the regulation of pancreatic beta-cell function. The aim of this study was to determine the effects of short-term exposure to NO on beta-cell gene expression and the activity of the transcription factor PDX-1. NO stimulated the activity of the ins...

journal_title：Biochemical and biophysical research communications

authors： Campbell SC,Richardson H,Ferris WF,Butler CS,Macfarlane WM

更新日期：2007-02-23 00:00:00

abstract：:The gene for acetyl-CoA carboxylase, the rate-limiting enzyme in the biosynthesis of long-chain fatty acids, contains two promoters; promoter I (PI) and promoter II (PII) which are responsible for generation of class I and class II ACC mRNAs, respectively. Class I ACC mRNAs are present in adipose tissue, but only a tr...

journal_title：Biochemical and biophysical research communications

authors： Ekhterae D,Tae HJ,Daniel S,Moller DE,Kim KH

更新日期：1996-10-14 00:00:00

abstract：:In multiple myeloma (MM), bone marrow microenvironment has an important role for the survival and growth of plasma cells. We previously showed that a high bone turnover, induced by ovariectomy, increased MM cells growth in the 5T2MM model. The present study characterized a new plasma cell line (5THL) which was isolate...

journal_title：Biochemical and biophysical research communications

authors： Libouban H,Moreau MF,Baslé MF,Bataille R,Chappard D

更新日期：2004-04-09 00:00:00

abstract：:The processing of human gastric procathepsin E to its mature form, cathepsin E, was studied at pH 3.5. The results revealed the autocatalytic and apparently one-step conversion of procathepsin E to cathepsin E within 10 min of incubation at 14 degrees C under the conditions used. Analyses of the amino acid sequences o...

journal_title：Biochemical and biophysical research communications

authors： Athauda SB,Takahashi T,Kageyama T,Takahashi K

更新日期：1991-02-28 00:00:00

abstract：:Clinicians successfully utilize high uptake of radiolabeled glucose via PET scanning to localize metastases in melanoma patients. To take advantage of this altered metabolome, 3-bromopyruvate (BrPA) was used to overcome the notorious resistance of melanoma to cell death. Using four melanoma cell lines, BrPA triggered ...

journal_title：Biochemical and biophysical research communications

authors： Qin JZ,Xin H,Nickoloff BJ

更新日期：2010-05-28 00:00:00

abstract：:Processing of Bacillus thuringiensis protoxins to toxins by midgut proteinases from a strain of the Indianmeal moth, Plodia interpunctella (Hubner), resistant to B. thuringiensis subspecies entomocidus (HD-198) was slower than that by midgut proteinases from the susceptible parent strain or a strain resistant to B. th...

journal_title：Biochemical and biophysical research communications

authors： Oppert B,Kramer KJ,Johnson DE,MacIntosh SC,McGaughey WH

更新日期：1994-02-15 00:00:00

abstract：:We established cell lines that stably express orphan GPCR GPR174 using CHO cells, and studied physiological and pharmacological features of the receptor. GPR174-expressing cells showed cell-cell adhesion with localization of actin filaments to cell membrane, and revealed significant delay of cell proliferation. Since ...

journal_title：Biochemical and biophysical research communications

authors： Sugita K,Yamamura C,Tabata K,Fujita N

更新日期：2013-01-04 00:00:00

abstract：:We describe a new approach to DNA hybridization assays using metal-enhanced fluorescence. Thiolated oligonucleotides were bound to silver particles on a glass substrate. Addition of a complementary fluorescein-labeled oligonucleotide resulted in a dramatic time-dependent 12-fold increase in fluorescence intensity duri...

journal_title：Biochemical and biophysical research communications

authors： Malicka J,Gryczynski I,Lakowicz JR

更新日期：2003-06-20 00:00:00

abstract：:The protein kinase C inhibitor C-I reduced superoxide production by human neutrophils in response to phorbol myristate acetate by greater than 50%. In contrast to its effects in oxidative metabolism, 100 microM C-I caused minimal inhibition (5-18%) of lysozyme release in response to phorbol myristate acetate. Enzyme r...

journal_title：Biochemical and biophysical research communications

authors： Salzer W,Gerard C,McCall C

更新日期：1987-10-29 00:00:00

abstract：:Complementary DNA corresponding to total poly(A)+-RNA from the human A431 epidermoid carcinoma cell line was cloned in the phage expression vector lambda gt 11. An epidermal growth factor (EGF) receptor cDNA clone was obtained by screening of the expression library with a rabbit polyclonal antibody (IgG), raised to th...

journal_title：Biochemical and biophysical research communications

authors： Simmen FA,Gope ML,Schulz TZ,Wright DA,Carpenter G,O'Malley BW

更新日期：1984-10-15 00:00:00

abstract：:Members of the Crk family of adaptor proteins are key players in signal transduction from a variety of cell surface receptors. CrkI and CrkII are two alternative-spliced forms of a single gene which possess an N-terminal SH2 domain and an SH3 domain that mediate interaction with other proteins. CrkII possesses an addi...

journal_title：Biochemical and biophysical research communications

authors： Nath PR,Dong G,Braiman A,Isakov N

更新日期：2016-02-05 00:00:00

abstract：:Recent clinical studies have shown that inorganic arsenic trioxide (As(2)O(3)) at low concentrations induces complete remission with minimal toxicity in patients with refractory acute promyelocytic leukemia (APL). Preclinical studies suggest that As(2)O(3) induces apoptosis and possibly differentiation in APL cells. L...

journal_title：Biochemical and biophysical research communications

authors： Ora I,Bondesson L,Jönsson C,Ljungberg J,Pörn-Ares I,Garwicz S,Pâhlman S

更新日期：2000-10-14 00:00:00

abstract：:The fission yeast S-phase regulator Mcl1, an orthologue of budding yeast Ctf4, is an interacting protein of DNA polymerase alpha and an important factor to ensure DNA replication and sister chromatid cohesion. Deletion of this protein results in severe cohesion defects, however, the function and cellular role of this ...

journal_title：Biochemical and biophysical research communications

authors： Mamnun YM,Katayama S,Toda T

更新日期：2006-11-10 00:00:00

abstract：:The yeast Saccharomyces cerevisiae is able to sense the availability and quality of nitrogen sources and the intrinsic variation of amino acid disponibility for protein synthesis. When this yeast is provided with secondary nitrogen sources, transcription of genes encoding enzymes involved in their catabolism is elicit...

journal_title：Biochemical and biophysical research communications

authors： Hernández H,Aranda C,Riego L,González A

更新日期：2011-01-21 00:00:00

abstract：:Blot-hybridization of sea urchin (Tripneustes gratilla) genomic DNA with a cloned rDNA probe revealed individual variation in the length of the rDNA repeat unit and also in the non-transcribed spacer sequences. The number of distinct rDNA repeat subclasses distinguishable within any one sea urchin was limited and usua...

journal_title：Biochemical and biophysical research communications

authors： Simmen FA,Mandel M,Humphreys T

更新日期：1986-06-13 00:00:00

abstract：:Upon incubation of bovine thyroglobulin with trypsin at high enzyme/substrate ratio, some fragments with apparent masses between 18 and 31 kDa resisted prolonged digestion. Their NH2-terminal sequences were determined. All fragments overlapped with some of the Cys-rich repeats that compose a large part of thyroglobuli...

journal_title：Biochemical and biophysical research communications

authors： Gentile F,Palumbo G

更新日期：1993-11-15 00:00:00

abstract：:Several studies have shown that transplantation of embryonic stem cells into diabetic animals either improved or normalized blood glucose levels. In this study, we examined the dose-dependent effect of early (prediabetic stage) intravenous administration of human umbilical cord blood (HUCB) mononuclear cells on blood ...

journal_title：Biochemical and biophysical research communications

authors： Ende N,Chen R,Reddi AS

更新日期：2004-12-17 00:00:00

abstract：:Bromodomains are epigenetic readers that specifically bind to the acetyl lysine residues of histones and transcription factors. Small molecule BET bromodomain inhibitors can disrupt this interaction which leads to potential modulation of several disease states. Here we describe the binding properties of a novel BET in...

journal_title：Biochemical and biophysical research communications

authors： Kharenko OA,Gesner EM,Patel RG,Norek K,White A,Fontano E,Suto RK,Young PR,McLure KG,Hansen HC

更新日期：2016-08-12 00:00:00

abstract：:To examine the effects of a replacement of the proximal or the distal histidine on the structure of hemoglobin (Hb), absorption and circular dichroic (CD) spectra of five species of Hbs M in the visible region were measured. Four Hbs M had a characteristic but a similar absorption spectrum upon amino acid substitution...

journal_title：Biochemical and biophysical research communications

authors： Nagai M,Takama S,Yoneyama Y

更新日期：1985-04-30 00:00:00

abstract：:The effect of musk xylene on contents of both cytochrome P-450IA1 and cytochrome P-450IA2 in rat liver was investigated using Western blotting analysis. Rats were treated i.p. for five consecutive days with either 50, 100 or 200 mg musk xylene/kg body weight. Musk xylene increased both total cytochrome P-450 and cytoc...

journal_title：Biochemical and biophysical research communications

authors： Iwata N,Minegishi K,Suzuki K,Ohno Y,Kawanishi T,Takahashi A

更新日期：1992-04-15 00:00:00

abstract：:Antithrombin inhibits chemokine-induced migration of neutrophils by activating heparan sulfate proteoglycan-dependent signaling. Mechanisms of antithrombin's effects on neutrophils were, therefore, studied by testing function and expression of heparan sulfate proteoglycans in RT-PCR or flow cytometry and cell migratio...

journal_title：Biochemical and biophysical research communications

authors： Kaneider NC,Egger P,Dunzendorfer S,Wiedermann CJ

更新日期：2001-09-14 00:00:00

abstract：:Amylin, an islet amyloid peptide secreted by the pancreatic beta cell, has been proposed as a humoral regulator of islet insulin secretion. Four separate preparations of amylin were tested for effects on hormone secretion in both freshly isolated and cultured rat islets and in HIT-T15, hamster insulinoma cells. With a...

journal_title：Biochemical and biophysical research communications

authors： Broderick CL,Brooke GS,DiMarchi RD,Gold G

更新日期：1991-06-28 00:00:00

abstract：:The effect of thyroid-stimulating hormone receptor (TSHR) on hepatic lipid accumulation in vivo is not fully understood. Further, while TSHR in the thyroid has been studied extensively, whether and how the absence of TSHR in the liver affects systemic energy metabolism has not yet been reported. To examine these effec...

journal_title：Biochemical and biophysical research communications

authors： Zhou L,Wu K,Zhang L,Gao L,Chen S

更新日期：2018-02-26 00:00:00

abstract：:Circular (circ)RNAs have been implicated in cancer development. However, few studies have examined the role of circRNAs in papillary thyroid cancer (PTC). In this study we found that circNUP214 was upregulated in clinical PTC specimens relative to adjacent normal tissue. In vitro analyses showed that circNUP214 knockd...

journal_title：Biochemical and biophysical research communications

authors： Li X,Tian Y,Hu Y,Yang Z,Zhang L,Luo J

更新日期：2018-12-09 00:00:00

abstract：:Interaction of P2X7 receptor with P2X4 receptor has recently been suggested, but it remains unclear whether P2X4 receptor is involved in P2X7 receptor-mediated events, such as cell death of macrophages induced by high concentrations of extracellular ATP. Here, we present evidence that P2X4 receptor does play a role in...

journal_title：Biochemical and biophysical research communications

authors： Kawano A,Tsukimoto M,Noguchi T,Hotta N,Harada H,Takenouchi T,Kitani H,Kojima S

更新日期：2012-03-09 00:00:00