当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Down-regulation of connexin43 gap junction by serum deprivation in human endothelial cells was improved by (-)-Epigallocatechin gallate via ERK MAP kinase pathway.

Down-regulation of connexin43 gap junction by serum deprivation in human endothelial cells was improved by (-)-Epigallocatechin gallate via ERK MAP kinase pathway.

Abstract：

:Intercellular communication through gap junctions (GJIC) plays an essential role in maintaining the functional integrity of vascular endothelium. Despite emerging evidence suggests that (-)-Epigallocatechin gallate (EGCG) may improve endothelial function. However, its effect on Cx43 gap junction in endothelial cells remains unexplored. Here we investigated the effect of EGCG on connexin43 (Cx43) gap junction in endothelial cells. The levels of Cx43 protein in human umbilical vein endothelial cells (HUVECs) cultured under serum-deprivation 48 h decreased about 50%, accompanied by decreased GJIC. This reduction can be reversed by treatments with EGCG. In addition, EGCG activated ERK, P38, and JNK mitogen-activated protein kinases (MAPKs), which were supposed to participate in the regulation of Cx43. A MEK inhibitor PD98059, but not SB203580 (a p38 kinase inhibitor) or SP600125 (a JNK kinase inhibitor), abolished the effects of EGCG on Cx43 expression and GJIC. Moreover, although both Akt and eNOS phosphorylation were time-dependently augmented by EGCG, neither PI3K inhibitor LY294002 nor eNOS inhibitor L-NAME blocked the effects of EGCG on Cx43 gap junctions. Thus, EGCG attenuated Cx43 down-regulation and impaired GJIC induced by serum deprivation, ERK MAPK Signal transduction pathway appears to be involved in these processes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zhao Y,Yu L,Xu S,Qiu F,Fan Y,Fu G

doi

10.1016/j.bbrc.2010.11.096

subject

Has Abstract

pub_date

2011-01-07 00:00:00

pages

217-22

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)02162-5

journal_volume

404

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Molecular imprinting: synthesis of polymer particles with antibody-like binding characteristics for glucose oxidase.

    abstract：:A phosphate buffer containing a mixture of glucose oxidase, acrylic acid derivatives, N,N'-1,2 dihydroxy-ethylene-bis(acrylamide), N,N'-(methylene)-bisacrylamide and surface-modified silica was radically polymerized with (NH4)2S2O8. The polymer formed a thin layer around the silica beads. After sieving of these polyme...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1522

    authors： Burow M,Minoura N

    更新日期：1996-10-14 00:00:00

  • Folding-dependent in vitro protein splicing of the Saccharomyces cerevisiae VMA1 protozyme.

    abstract：:VMA1 translational product undergoes excision of a 50-kDa intervening segment (VDE: VMA1-derived endonuclease) and religation of the flanking regions to create a 69-kDa catalytic subunit of vacuolar membrane H+-ATPase. VDEs conjugated with polypeptides at both N- and C-terminal ends were expressed in Escherichia coli ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0826

    authors： Kawasaki M,Makino S,Matsuzawa H,Satow Y,Ohya Y,Anraku Y

    更新日期：1996-05-24 00:00:00

  • Autophagy protects type II alveolar epithelial cells from Mycobacterium tuberculosis infection.

    abstract：:This study was designed to investigate the protective effect of the autophagy signaling pathway against Mycobacterium tuberculosis infection in type II alveolar epithelial cells. An in vitro M. tuberculosis system was established using human A549 cells. Infection-induced changes in the expression of the autophagic mar...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.01.111

    authors： Guo XG,Ji TX,Xia Y,Ma YY

    更新日期：2013-03-08 00:00:00

  • Regulation of the solubilized bovine cerebral cortex muscarinic receptor by GTP and Na+.

    abstract：:The muscarinic acetylcholine receptor was solubilized, in a sensitive form for GTP and Na+, from bovine cerebral cortex using a zwitterionic detergent 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate. The solubilized muscarinic receptor displayed characteristics as follows: (1) high affinity to nanomolar co...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91709-6

    authors： Kuno T,Shirakawa O,Tanaka C

    更新日期：1983-05-16 00:00:00

  • Chemerin is a novel regulator of lactogenesis in bovine mammary epithelial cells.

    abstract：:Chemerin is a chemoattractant cytokine (chemokine) produced by adipocytes and hepatocytes; it regulates insulin sensitivity and adipocyte differentiation. The objective of this study was to investigate the effect of chemerin on the expression of genes related to lactogenesis and the regulators of chemerin signaling in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.08.105

    authors： Suzuki Y,Haga S,Katoh D,So KH,Choi KC,Jung US,Lee HG,Katoh K,Roh SG

    更新日期：2015-10-23 00:00:00

  • Rapid purification of inositol monophosphate phosphatase from beef brain.

    abstract：:A procedure is described for preparation of homogeneous inositol monophosphate phosphatase (EC 3.1.3.25) from beef brain in less than 2 days with an overall recovery of 15-25%. This enzyme, an essential part of the inositol phospholipid cycle in brain, is a proposed site of action of lithium ions in manic-depressive d...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80816-7

    authors： Meek JL,Rice TJ,Anton E

    更新日期：1988-10-14 00:00:00

  • Crystal structure of the death effector domains of caspase-8.

    abstract：:Caspase-8 is a key mediator in various biological processes such as apoptosis, necroptosis, inflammation, T/B cells activation, and cell motility. Caspase-8 is characterized by the N-terminal tandem death effector domains (DEDs) and the C-terminal catalytic protease domain. The DEDs mediate diverse functions of caspas...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.05.054

    authors： Shen C,Yue H,Pei J,Guo X,Wang T,Quan JM

    更新日期：2015-07-31 00:00:00

  • Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade.

    abstract：:Animals and plants respond to bacterial infections and environmental stresses by inducing overlapping repertoires of defense genes. How the signals associated with infection and abiotic stresses are differentially integrated within a whole organism remains to be fully addressed. We show that the transcription of a Cae...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.08.190

    authors： Kurz CL,Shapira M,Chen K,Baillie DL,Tan MW

    更新日期：2007-11-16 00:00:00

  • Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases.

    abstract：:The human cDNA encoding a novel protein serine/threonine kinase most closely related to p70 S6 kinase was isolated from the human erythroleukemia cDNA library and termed p70(S6Kbeta). p70(S6Kbeta) has 67% amino acid identity in overall sequence with human p70(S6K), and the potential phosphorylation sites of p70(S6K) a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9784

    authors： Saitoh M,ten Dijke P,Miyazono K,Ichijo H

    更新日期：1998-12-18 00:00:00

  • Tumor necrosis factor upregulates interleukin-4 receptors on murine sarcoma cells.

    abstract：:We have previously shown that murine solid tumor cells express high affinity IL-4 receptors (IL-4R) which are internalized after binding to ligand. In the present study, we have examined the regulation of IL-4R by TNF. We demonstrate that TNF upregulated the expression of IL-4R on murine MCA-106 sarcoma cells. Maximum...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2636

    authors： Puri RK,Leland P

    更新日期：1993-12-30 00:00:00

  • Modulation of autonomic neuroeffector transmission by nitric oxide in guinea pig ileum.

    abstract：:NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, markedly enhanced tonic ("hump") responses to transmural stimulation in guinea pig ileum longitudinal muscle. The enhancement of the hump responses was probably due to a prejunctional effect on substance P-like neurotransmission, since the acti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81028-9

    authors： Gustafsson LE,Wiklund CU,Wiklund NP,Persson MG,Moncada S

    更新日期：1990-11-30 00:00:00

  • Comparison of the microtubule formation induced by cytosynalin and MAPs.

    abstract：:A comparison was made of cytosynalin- and MAPs-induced microtubule formation. Cytosynalin (a 35 kDa cytoskeleton-interacting and calmodulin-binding protein) facilitated more rapid and extensive microtubule formation than MAPs. Electron microscopic examination revealed that the cytosynalin-induced microtubules were 24 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)90587-0

    authors： Itoh K,Sobue K

    更新日期：1987-07-31 00:00:00

  • Poly(rC)-binding protein 2 interacts with the oligo(rC) tract of coxsackievirus B3.

    abstract：:The human poly(rC)-binding protein (PCBP) 2 is known to interact with enteroviral RNA. Here, the interaction of PCBP2 with RNA target sequences at the 5' end of the coxsackievirus B3 genome was investigated. Using the electrophoretic mobility shift assay and the yeast three-hybrid system, a short oligo(rC) tract conne...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.12.038

    authors： Zell R,Ihle Y,Seitz S,Gündel U,Wutzler P,Görlach M

    更新日期：2008-02-22 00:00:00

  • Effects of steroid and thyroid hormones on synthesis of atrial natriuretic peptide by cultured atrial myocytes of rat.

    abstract：:The in vitro effects of various steroid and thyroid hormones on synthesis of rat atrial natriuretic peptide (rANP) were studied using new-born rat atrial myocytes in culture. Dexamethasone, testosterone and triiodothyronine markedly stimulated both synthesis and secretion of immunoreactive (IR)-rANP with the same peak...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)91326-x

    authors： Matsubara H,Hirata Y,Yoshimi H,Takata S,Takagi Y,Iida T,Yamane Y,Umeda Y,Nishikawa M,Inada M

    更新日期：1987-05-29 00:00:00

  • Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins.

    abstract：:Epithelin/granulin growth factor is synthesized as a 593 amino acid precursor protein that contains 7.5 imperfectly conserved repeats of approximately 57 amino acids. Processed epithelin/granulin peptides have been isolated from vertebrate/invertebrate species and are growth factors implicated in epithelial and haemic...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0317

    authors： Trinh DP,Brown KM,Jeang KT

    更新日期：1999-03-16 00:00:00

  • Suppression of HIF-1α accumulation by betulinic acid through proteasome activation in hypoxic cervical cancer.

    abstract：:Betulinic acid (BA) exhibits various biological activities such as anti-bacterial, anti-inflammatory, anti-human papilloma virus (HPV), and anti-cancer activities. HPV infection is associated with a high risk of cervical cancer, which is the leading cause of deaths among women worldwide. Therefore, BA is an attractive...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.01.031

    authors： Kim HJ,Cho HS,Ban HS,Nakamura H

    更新日期：2020-03-12 00:00:00

  • Retinoic acid signaling regulates embryonic clock hairy2 gene expression in the developing chick limb.

    abstract：:Embryo development proceeds under strict temporal control and an embryonic molecular clock (EC), evidenced by cyclic gene expression, is operating during somite formation and limb development, providing temporal information to precursor cells. In somite precursor cells, EC gene expression and periodicity depends on Re...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.06.077

    authors： Sheeba CJ,Palmeirim I,Andrade RP

    更新日期：2012-07-13 00:00:00

  • NADH-ferric reductase activity associated with dihydropteridine reductase.

    abstract：:In mammals dietary ferric iron is reduced to ferrous iron for more efficient absorption by the intestine. Analysis of a pig duodenal membrane fraction revealed two NADH-dependent ferric reductase activities, one associated with a b-type cytochrome and the other not. Purification and characterization of the non-cytochr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.2708

    authors： Lee PL,Halloran C,Cross AR,Beutler E

    更新日期：2000-05-19 00:00:00

  • Role of growth hormone receptor signaling in osteogenesis from murine bone marrow progenitor cells.

    abstract：:Growth hormone (GH) regulates many of the factors responsible for controlling the development of bone marrow progenitor cells (BMPCs). The aim of this study was to elucidate the role of GH in osteogenic differentiation of BMPCs using GH receptor null mice (GHRKO). BMPCs from GHRKO and their wild-type (WT) littermates ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.10.035

    authors： Cool SM,Grünert M,Jackson R,Li H,Nurcombe V,Waters MJ

    更新日期：2005-12-16 00:00:00

  • Identification and characterization of proteins involved in stolon adhesion in the highly invasive fouling ascidian Ciona robusta.

    abstract：:Adhesive ascidians have caused serious biofouling problems and huge economic losses in marine ecosystems. However, adhesion mechanisms, particularly on functional proteins involved in ascidian adhesion, remain largely unexplored. Here, we identified 26 representative stolon proteins from the highly invasive fouling as...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.01.053

    authors： Li S,Huang X,Chen Y,Li X,Zhan A

    更新日期：2019-02-26 00:00:00

  • Role of pigment epithelium-derived factor in the involution of hemangioma: autocrine growth inhibition of hemangioma-derived endothelial cells.

    abstract：:Hemangioma is a benign tumor derived from abnormal blood vessel growth. Unlike other vascular tumor counterparts, a hemangioma is known to proliferate during its early stage but it is followed by a stage of involution where regression of the tumor occurs. The critical onset leading to the involution of hemangioma is c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.10.052

    authors： Kim KJ,Yun JH,Heo JI,Lee EH,Min HS,Choi TH,Cho CH

    更新日期：2014-11-14 00:00:00

  • Toll-like receptor 4 protects against irradiation-induced hematopoietic injury by promoting granulopoiesis and alleviating marrow adipogenesis.

    abstract：:Irradiation induces severe damage in the hematopoietic system, which leads to bone marrow hyperplasia, pancytopenia, and aggravated tissue formation in bone marrow. Studies have shown that Toll-like receptor 4 (TLR4) has a protective effect against irradiation, but the underlying mechanism remains unclear. In this stu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.10.027

    authors： Sun Z,Wu K,Lin Q,Fei H,Jiang H,Chen T,Yuan Y

    更新日期：2019-12-03 00:00:00

  • Is cAMP the obligatory second messenger in the action of lutropin on Leydig cell steroidogenesis.

    abstract：:Two adenylate cyclase inhibitors: 9-(tetrahydro-2-furyl)adenine and 2'5'-dideoxyadenosine decreased cAMP levels in LH-stimulated immature rat Leydig cells by 20-40%, independent of the concentration of LH. Steroid production was not correlated with this decrease in cAMP, but was increased (146%). The phorbol ester 4 b...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91063-0

    authors： Themmen AP,Hoogerbrugge JW,Rommerts FF,van der Molen HJ

    更新日期：1985-05-16 00:00:00

  • Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif.

    abstract：:Coordinated migration of endothelial cells models the remodeling of existing endothelia as well as angiogenesis and vasculogenesis. Platelet-endothelial cell adhesion molecule-1, PECAM-1, a transmembrane endothelial adhesion protein, binds and activates the tyrosine phosphatase SHP-2 via phosphotyrosines 663 and 686. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02982-0

    authors： Gratzinger D,Barreuther M,Madri JA

    更新日期：2003-01-31 00:00:00

  • Reversibility of the Snail-induced epithelial-mesenchymal transition revealed by the Cre-loxP system.

    abstract：:The epithelial-mesenchymal transition (EMT), a key process in the tumor metastatic cascade, is characterized by the loss of cell-cell junctions and cell polarity, as well as the acquisition of migratory and invasive properties. Snail is an EMT-inducer whose expression in several different epithelial cells, e.g., Madin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.02.012

    authors： Ozawa M,Kobayashi W

    更新日期：2015-03-13 00:00:00

  • Circular dichroism spectra demonstrate formation of the thrombin-binding DNA aptamer G-quadruplex under stabilizing-cation-deficient conditions.

    abstract：:It is noteworthy that the formation of the DNA G-quadruplex is induced by factors other than stabilizing cations because this event probably occurs in living cells. Previous studies have shown that thrombin-binding DNA aptamer (TBA) forms a chair-type intramolecular G-quadruplex structure that binds with thrombin prot...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.11.088

    authors： Nagatoishi S,Tanaka Y,Tsumoto K

    更新日期：2007-01-19 00:00:00

  • Study of multi-drug resistant mechanisms in a taxol-resistant hepatocellular carcinoma QGY-TR 50 cell line.

    abstract：:Cancer chemotherapy with taxol often fails due to acquired resistance of cancer cells, which is frequently associated with an overexpression of P-gp and alterations of beta-tubulin. A taxol-resistant cell line, QGY-TR50, derived from a human hepatocellular carcinoma (HCC) QGY-7703 cell line was used to investigate the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4268

    authors： Zhou J,Cheng SC,Luo D,Xie Y

    更新日期：2001-02-09 00:00:00

  • Imaging mass spectroscopy delineates the thinned and thickened walls of intracranial aneurysms.

    abstract：OBJECT:The wall thickness of intracranial aneurysms (IAs) is heterogeneous. Although thinning of the IA wall is thought to contribute to IA rupture, the underlying mechanism remains poorly understood. Recently, imaging mass spectroscopy (IMS) has been used to reveal the distribution of phospholipids in vascular disease...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.10.133

    authors： Ikedo T,Minami M,Kataoka H,Hayashi K,Nagata M,Fujikawa R,Yamazaki F,Setou M,Yokode M,Miyamoto S

    更新日期：2018-01-01 00:00:00

  • Identification of poly(ADP-ribose) polymerase-1 as the OXPHOS-generated ATP sensor of nuclei of animal cells.

    abstract：:Our results show that in the intact normal animal cell mitochondrial ATP is directly connected to nuclear PARP-1 by way of a specific adenylate kinase enzymatic path. This mechanism is demonstrated in two models: (a) by its inhibition with a specific inhibitor of adenylate kinase, and (b) by disruption of ATP synthesi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.12.004

    authors： Kun E,Kirsten E,Hakam A,Bauer PI,Mendeleyev J

    更新日期：2008-02-08 00:00:00

  • Inhibition of histone deacetylase activity is a novel function of the antifolate drug methotrexate.

    abstract：:Methotrexate (MTX) is a dihydrofolate reductase (DHFR) inhibitor widely used for treating human cancers, and overexpression of histone deacetylase (HDAC) is usually found in tumors. HDAC inhibitors (HDACi) can reactivate tumor suppressor genes and serve as potential anti-cancer drugs. In this study, we found that MTX ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.12.072

    authors： Yang PM,Lin JH,Huang WY,Lin YC,Yeh SH,Chen CC

    更新日期：2010-01-15 00:00:00