Comparison of the microtubule formation induced by cytosynalin and MAPs.

abstract：:E-selectin has a "multi-recognition" capability in terms of epitope binding specificity, depending on adhesion conditions (static vs. low- or high-shear stress dynamic systems). Specifically, (i) adhesion based on expression of alpha 2-->3 sialylated Le(x) (SLe(x)) is prominent under static or low shear stress dynamic...

journal_title：Biochemical and biophysical research communications

authors： Kojima N,Handa K,Newman W,Hakomori S

更新日期：1992-12-30 00:00:00

abstract：:The present study examines whether and to what extent the profiles of proteolytic-related genes are altered in atrophying muscle during prolonged food deprivation. Long-term fasted animals exhibited three metabolic phases characterized by changes in lipid and protein utilization. Starvation induced an increase in some...

journal_title：Biochemical and biophysical research communications

authors： Bertile F,Le Maho Y,Raclot T

更新日期：2003-11-28 00:00:00

abstract：:An alternative molecular biology strategy is needed to characterize cholinephosphotransferase (CPT) gene because of the complexity of the problem associated with the solubilization of the membrane-bound enzyme without denaturation. We have synthesized five heterologous oligonucleotide probes based on the published yea...

journal_title：Biochemical and biophysical research communications

authors： Das SK,Beg O,Mukherjee S

更新日期：1997-12-18 00:00:00

abstract：:Inflammation has an essential role in regulating the pathogenesis of acute respiratory distress syndrome (ARDS). The serine/threonine kinase PIM2 is highly expressed in human macrophages, and exhibits regulatory role in inflammatory response. However, its effect on ARDS progression has not been investigated and still ...

journal_title：Biochemical and biophysical research communications

authors： Wang F,Xu L,Dong G,Zhu M,Liu L,Wang B

更新日期：2020-12-17 00:00:00

abstract：:Rhabdomyosarcomas (RMS) represent the most common childhood soft-tissue sarcoma. Over the past few decades outcomes for low and intermediate risk RMS patients have slowly improved while patients with metastatic or relapsed RMS still face a grim prognosis. New chemotherapeutic agents or combinations of chemotherapies h...

journal_title：Biochemical and biophysical research communications

authors： Kaylani SZ,Xu J,Srivastava RK,Kopelovich L,Pressey JG,Athar M

更新日期：2013-06-14 00:00:00

abstract：:A growing number of studies have indicated that microRNAs (miRNAs) are critical regulators of carcinogenesis and cancer progression and may serve as potential therapeutic tools for cancer therapy. Frizzled7 (Fzd7), the most important receptor of the Wnt signaling pathway, is extensively involved in cancer development ...

journal_title：Biochemical and biophysical research communications

authors： Ren W,Li C,Duan W,Du S,Yang F,Zhou J,Xing J

更新日期：2016-01-15 00:00:00

abstract：:Cilostazol is a drug licensed for the treatment of intermittent claudication. Its main action is to elevate intracellular levels of cyclic monophosphate (cAMP) by inhibiting the activity of type III phosphodiesterase, a cAMP-degrading enzyme. The effects of cilostazol on fatty acid oxidation (FAO) are as yet unknown. ...

journal_title：Biochemical and biophysical research communications

authors： Wang B,Zhu L,Sui S,Sun C,Jiang H,Ren D

更新日期：2014-05-09 00:00:00

abstract：:2-Hydroxy-5-nitrobenzyl bromide, a highly reactive reagent towards tryptophan residues in proteins, is shown to activate the passive proton flux through the inner mitochondrial membrane of bovine heart submitochondrial particles (ETPH). When added at low concentrations, the reagent increased both the ATPase activity o...

journal_title：Biochemical and biophysical research communications

authors： Solaini G,Baracca A,Parenti Castelli G,Rossi CA

更新日期：1988-08-30 00:00:00

abstract：:The epithelial sodium channel (ENaC) controls colonic sodium absorption. So far, investigation of ENaC was limited by an unexplained lack of steroid-dependent ENaC expression in cultured intestinal cells, which we aimed to resolve. HT-29/B6 cells constitutively expressed the alpha-ENaC subunit, while beta- and gamma-E...

journal_title：Biochemical and biophysical research communications

authors： Zeissig S,Fromm A,Mankertz J,Zeitz M,Fromm M,Schulzke JD

更新日期：2006-06-16 00:00:00

abstract：:Sirtuin1 (SIRT1), which is regulated by microRNA-34a (miR-34a), can modulate pathophysiology processes, including nonalcoholic fatty liver disease and intestinal ischemia/reperfusion injury. We previously reported that SIRT1, an NAD+-dependent deacetylase, plays a vital role in the development of neuropathic pain. How...

journal_title：Biochemical and biophysical research communications

authors： Chen S,Gu Y,Dai Q,He Y,Wang J

更新日期：2019-09-03 00:00:00

abstract：:ADP-ribosylation by cholera toxin of the guanine nucleotide binding regulatory protein (Gs) of rat liver membrane adenylate cyclase was inhibited by 0.1-1 mM MDL 12330A or 0.1-1 mM chlorpromazine. Basal as well as cholera toxin activated adenylate cyclase activity in liver membranes was also inhibited by the two drugs...

journal_title：Biochemical and biophysical research communications

authors： Bitonti AJ

更新日期：1984-04-30 00:00:00

abstract：:Methylene blue (MB) is a blue cationic thiazine dye and currently used in different medical settings. Notably, there have been several attempts to introduce MB for attenuating pain in the last decade. Some clinical studies reported remarkable results, which, however, have been much debated. In addition, accumulating e...

journal_title：Biochemical and biophysical research communications

authors： Lee SW,Moon SW,Park JS,Suh HR,Han HC

更新日期：2021-01-16 00:00:00

abstract：:Activities of the hepadnavirus polymerases are known to include those of DNA polymerase, reverse transcriptase and RNase H. To date, it has been difficult or impossible to clone and express the product as an active enzyme. In this study, full length capped RNA encoding Duck Hepatitis B Virus (DHBV) polymerase was prod...

journal_title：Biochemical and biophysical research communications

authors： Howe AY,Elliott JF,Tyrrell DL

更新日期：1992-12-15 00:00:00

abstract：:We have previously demonstrated that the cyclin-dependent kinase inhibitor (Cki) Sic1 of Saccharomyces cerevisiae is phosphorylated in vitro by the CK2 kinase on Ser(201) residue. Moreover, we have collected evidence showing that Sic1 is functionally and structurally related to mammalian Cki p27(Kip1) and binds to the...

journal_title：Biochemical and biophysical research communications

authors： Barberis M,Pagano MA,Gioia LD,Marin O,Vanoni M,Pinna LA,Alberghina L

更新日期：2005-11-04 00:00:00

abstract：:By performing immunofluorescence staining assays in confluent COS-7 cells, hepatitis B virus core, small surface and large surface proteins were found to localize largely in the nucleus, diffusely in the cytoplasm, and accumulatively in a perinuclear area, respectively. When two proteins were co-expressed, the core pr...

journal_title：Biochemical and biophysical research communications

authors： Yeh CT,Ou JH,Chu CM,Liaw YF

更新日期：1994-09-15 00:00:00

abstract：:Myocardial stunning (temporary post-ischaemic contractile dysfunction) may be caused by oxidative stress and/or impaired myocyte calcium homeostasis. Regional myocardial stunning was induced in open-chest pigs (segment shortening reduced to 68.3+/-4.7% of baseline) by repetitive brief circumflex coronary occlusion (I/...

journal_title：Biochemical and biophysical research communications

authors： Kumar S,Hall RJ,Mani AR,Moore KP,Camici PG,Rimoldi OE,Williams AJ,Macleod KT

更新日期：2009-09-11 00:00:00

abstract：:The effect of vitamin A supplementation on stearoyl-CoA desaturase gene 1 expression in mouse liver was characterized. Normal BALB/c mice were fed 0.01% and 0.1% retinol palmitate as components of nonpurified diets. This treatment resulted in a 3-fold and a 7-fold induction of SCD1 mRNA levels, respectively, as determ...

journal_title：Biochemical and biophysical research communications

authors： Miller CW,Waters KM,Ntambi JM

更新日期：1997-02-03 00:00:00

abstract：:The polyamines spermidine, spermine and putrescine, by themselves, at physiological concentrations, induce the transport of the precursor of ornithine carbamoyltransferase into isolated rat liver mitochondria. The presence of polyamines in the transport medium results in the approach of both mitochondrial membranes, s...

journal_title：Biochemical and biophysical research communications

authors： Marcote MJ,González-Bosch C,Miralles VJ,Hernández-Yago J,Grisolía S

更新日期：1989-01-16 00:00:00

abstract：:The syndrome of generalized epilepsy with febrile seizures plus type 1 (GEFS+) has been associated to the gene SCN1B coding for the sodium channel beta1 subunit (Wallace, R. H. et al. (1998) Nature Genetics 19, 366-370). In patients, a mutation of the cysteine 121 to trpyptophane (C121W) would cause a lack of modulato...

journal_title：Biochemical and biophysical research communications

authors： Moran O,Conti F

更新日期：2001-03-23 00:00:00

abstract：:We recently reported enhanced tumor growth and stimulation of vascular endothelial growth factor (VEGF) expression in rat mammary carcinoma cells transfected with a human tissue inhibitor of metalloproteinases-1 (hTIMP-1) cDNA (1). In the present study, we examined if the composition of the stroma was altered in the t...

journal_title：Biochemical and biophysical research communications

authors： Yoshiji H,Buck TB,Harris SR,Ritter LM,Lindsay CK,Thorgeirsson UP

更新日期：1998-06-29 00:00:00

abstract：:Endothelin-like immunoreactivity (-LI) was detected in the kidney, spleen, skeletal muscle, lung and in plasma of the pig. The highest tissue levels were found in the lung (1.5 +/- 0.07 pmol/g) and the lowest in the muscle (0.08 +/- 0.02 pmol/g). I.v. infusion of endothelin (20 pmol/kg/min for 20 min) increased plasma...

journal_title：Biochemical and biophysical research communications

authors： Pernow J,Hemsén A,Lundberg JM

更新日期：1989-06-15 00:00:00

abstract：:The kallikrein family (KLK) has been implicated in cancer and may be useful as tumor markers. Here, we compared the 15 KLK genes' expression in malignant and normal breast tissues using real-time quantitative PCR. Most KLKs were expressed at lower levels in breast cancer compared to normal breast tissue. The only exce...

journal_title：Biochemical and biophysical research communications

authors： Mangé A,Desmetz C,Berthes ML,Maudelonde T,Solassol J

更新日期：2008-10-10 00:00:00

abstract：:Deregulation of the expression of human papillomavirus (HPV) oncogenes E6 and E7 plays a pivotal role in cervical carcinogenesis because the E6 and E7 proteins neutralize p53 and Rb tumor suppressor pathways, respectively. In approximately 90% of all cervical carcinomas, HPVs are found to be integrated into the host g...

journal_title：Biochemical and biophysical research communications

authors： Lee K,Lee AY,Kwon YK,Kwon H

更新日期：2011-08-26 00:00:00

abstract：:15-Deoxy-prostaglandin J(2)(15d-PGJ(2)) is an endogenous ligand of peroxisome proliferator-activated receptor gamma (PPARgamma) and plays an important role in the regulation of endothelial cell growth and apoptosis. However, the detailed mechanisms are poorly understood. We hypothesized that 15d-PGJ(2) might affect PD...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Fu M,Zhao L,Chen YE

更新日期：2002-10-18 00:00:00

abstract：:The development of adipose tissue is a precisely coordinated cellular process, in which both protein-coding and non-coding genes are involved. To characterize the in vivo function of a novel long non-coding RNA (lncRNAs), loss-of-function assays were performed with slincRAD knockdown mice. Down-regulation of slincRAD ...

journal_title：Biochemical and biophysical research communications

authors： Zhang P,Bai H,Li J,Liu J,Ma W,Xu B,Xia Q,Wang J,Fan Yi,Du Q

更新日期：2019-06-11 00:00:00

abstract：:The molecular structures of enzyme mimics may be modified to optimize their catalytic properties. In this study, to generate artificial enzyme mimics, Watson-Crick base paired DNA duplexes were designed as scaffolds which were assembled by nucleotides modified with specific functional groups. This process allowed vari...

journal_title：Biochemical and biophysical research communications

authors： Xu L,Ji C,Bai Y,He J,Liu K

更新日期：2013-05-10 00:00:00

abstract：:2-Amino-3,8-dimethylimidazo(4,5-f)quinoxaline (MeIQx) is a potent mutagen found in cooked food. MeIQx and its isotopically labelled (13C, 15N2 and 14C) analogues were synthesised and used for metabolic studies in vivo. An equimolar mixture of MeIQx and its 13C, 15N2 stable isotope labelled analogue (containing tracer ...

journal_title：Biochemical and biophysical research communications

authors： Gooderham NJ,Watson D,Rice JC,Murray S,Taylor GW,Davies DS

更新日期：1987-11-13 00:00:00

abstract：:Studies have shown similarities between the histopathological characteristics of NPC and Alzheimer's disease (AD) including amyloid and tau pathologies. While dysfunction in insulin signaling was widely detected in AD brain, the function of insulin signaling proteins has not been examined in NPC disease. In this study...

journal_title：Biochemical and biophysical research communications

authors： Ong QR,Lim ML,Chua CC,Cheung NS,Wong BS

更新日期：2012-08-03 00:00:00

abstract：:Previously, we reported that metabolism of arachidonic acid through the 5-lipoxygenase (5-LOX) pathway plays an important role in the survival and growth of human prostate cancer cells. Inhibition of 5-LOX by pharmacological inhibitors triggers apoptosis in prostate cancer cells within hours of treatment, which is pre...

journal_title：Biochemical and biophysical research communications

authors： Sundaram S,Ghosh J

更新日期：2006-01-06 00:00:00

abstract：:Small membrane-bound extracellular organelles known as articular cartilage matrix vesicles (ACVs) participate in pathologic mineralization in osteoarthritic articular cartilage. ACVs are also present in normal cartilage, although they have no known functions other than mineralization. Recently, RNA was identified in e...

journal_title：Biochemical and biophysical research communications

authors： Mitton E,Gohr CM,McNally MT,Rosenthal AK

更新日期：2009-10-23 00:00:00