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Binding and pharmacologic properties of peptides derived from human and rat angiotensin II (AII) mRNA.

Abstract：

:We investigated the binding and pharmacologic properties of peptides encoded by complementary mRNA derived from the human and rat angiotensinogen gene (human and rat IIA, respectively). Human IIA (identical with AII in 4 amino acids) inhibited binding of [125I]AII to rat adrenal glomerulosa particles (Ki = 0.62 +/- 0.09 microM) and competitively blocked, with similar potency, the ability of three AII receptor agonists to contract rabbit aorta. Rat IIA affected neither [125I]AII binding to glomerulosa particles nor the contractile response of AII. We conclude that rat IIA does not interact with AII or its receptors and that human IIA acts as a competitive inhibitor of AII at the receptor level.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wiest SA,Gesellchen PD,Zimmerman K,Steinberg MI

doi

10.1016/0006-291x(90)92114-f

subject

Has Abstract

pub_date

1990-07-31 00:00:00

pages

462-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)92114-F

journal_volume

170

pub_type

杂志文章

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